Limits...
Relation of microvascular dysfunction to exercise capacity and symptoms in patients with severe aortic stenosis

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The aim of this study was to assess the impact of left ventricular hypertrophy, myocardial fibrosis, myocardial perfusion reserve (MPR) and diastolic dysfunction on objectively measured aerobic exercise capacity (peak VO2) in severe aortic stenosis (AS)... Investigations and primary outcome measures; cardiac magnetic resonance (CMR) - left ventricular mass index (LVMI), MPR (calculated from absolute myocardial blood flow during adenosine hyperaemia and rest determined by model-independent deconvolution of signal intensity curves with an arterial input function), late gadolinium enhancement (LGE); echocardiography - AS severity, tissue Doppler-derived diastolic function; symptom-limited bicycle ergometer cardiopulmonary exercise testing (CPEX) - peak VO2... Four patients with variable LVMI, LGE and MPR are shown, Figure 1... Univariate analyses and results from the stepwise model selection for peak VO2 are summarised in Table 1... The relationship between peak VO2 and MPR is shown, Figure 2... Patients with higher NYHA Class had lower MPR (p=0.001)... Examining predictors of MPR the best stepwise model contained LVMI and LGE category as independent predictors, Table 2... MPR is a novel independent predictor of peak VO2 and is inversely related to NYHA functional class in severe AS... Microvascular dysfunction is determined by a combination of factors including AS severity, LVMI, diastolic perfusion time, myocardial fibrosis and LV filling pressure... Further work is required to determine the clinical significance of microvascular dysfunction in AS.

No MeSH data available.


Peak VO2 and MPR
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3106538&req=5

Figure 2: Peak VO2 and MPR

Mentions: Four patients with variable LVMI, LGE and MPR are shown, Figure 1. Univariate analyses and results from the stepwise model selection for peak VO2 are summarised in Table 1. Only MPR was of independent significance in predicting age and sex corrected peak VO2. The relationship between peak VO2 and MPR is shown, Figure 2. Patients with higher NYHA Class had lower MPR (p=0.001). Examining predictors of MPR the best stepwise model contained LVMI and LGE category as independent predictors, Table 2.


Relation of microvascular dysfunction to exercise capacity and symptoms in patients with severe aortic stenosis
Peak VO2 and MPR
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3106538&req=5

Figure 2: Peak VO2 and MPR
Mentions: Four patients with variable LVMI, LGE and MPR are shown, Figure 1. Univariate analyses and results from the stepwise model selection for peak VO2 are summarised in Table 1. Only MPR was of independent significance in predicting age and sex corrected peak VO2. The relationship between peak VO2 and MPR is shown, Figure 2. Patients with higher NYHA Class had lower MPR (p=0.001). Examining predictors of MPR the best stepwise model contained LVMI and LGE category as independent predictors, Table 2.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The aim of this study was to assess the impact of left ventricular hypertrophy, myocardial fibrosis, myocardial perfusion reserve (MPR) and diastolic dysfunction on objectively measured aerobic exercise capacity (peak VO2) in severe aortic stenosis (AS)... Investigations and primary outcome measures; cardiac magnetic resonance (CMR) - left ventricular mass index (LVMI), MPR (calculated from absolute myocardial blood flow during adenosine hyperaemia and rest determined by model-independent deconvolution of signal intensity curves with an arterial input function), late gadolinium enhancement (LGE); echocardiography - AS severity, tissue Doppler-derived diastolic function; symptom-limited bicycle ergometer cardiopulmonary exercise testing (CPEX) - peak VO2... Four patients with variable LVMI, LGE and MPR are shown, Figure 1... Univariate analyses and results from the stepwise model selection for peak VO2 are summarised in Table 1... The relationship between peak VO2 and MPR is shown, Figure 2... Patients with higher NYHA Class had lower MPR (p=0.001)... Examining predictors of MPR the best stepwise model contained LVMI and LGE category as independent predictors, Table 2... MPR is a novel independent predictor of peak VO2 and is inversely related to NYHA functional class in severe AS... Microvascular dysfunction is determined by a combination of factors including AS severity, LVMI, diastolic perfusion time, myocardial fibrosis and LV filling pressure... Further work is required to determine the clinical significance of microvascular dysfunction in AS.

No MeSH data available.