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Visualization and quantification of 4D blood flow distribution and energetics in the right ventricle

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Right ventricular (RV) function has important prognostic value in both right- and left-sided acquired and congenital heart diseases (1)... Assessment of RV function is challenging because of its complex crescent shaped geometry and load conditions being significantly influenced by respiration... Incremental insights into RV blood flow patterns have the potential to add to our understanding of RV function (2), but remain incompletely characterized... We hypothesized that a specific portion of the RV end-diastolic (ED) blood volume is prepared for effective systolic ejection and that this sub-volume can be identified based on its pre-systolic kinetic energy (KE) and location... Accordingly, the ED blood volume could be automatically separated into four functional flow components (3,4)(Figures 1 and 2)... The portion of RV inflow passing directly to outflow (Direct Flow), possessed a larger pre-systolic KE than the other three flow components (p<0.01)(Figure 3)... The Direct Flow had a larger volume than the other flow components (p<0.001), and was located mainly in the basal half of the ventricle (Figures 1 and 2)... The Residual Volume was larger than the Delayed Ejection Flow (p<0.01) and the Retained Inflow (p<0.05), and was located mainly in the apical half of the ventricle (Figures 1 and 2)... Semi-automatic analysis of 4D CMR velocity data allows separation of RV flow into distinct functional components... The present findings suggest that diastolic flow in the normal RV creates favorable conditions for effective systolic ejection, defined by pre-systolic KE and location, for the Direct Flow component... These flow-specific aspects of RV diastolic-systolic coupling may provide new useful perspectives on RV- and interventricular function in health and disease.

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End-diastolic kinetic energy for the four right ventricular flow components in healthy subjects.
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Figure 3: End-diastolic kinetic energy for the four right ventricular flow components in healthy subjects.

Mentions: The portion of RV inflow passing directly to outflow (Direct Flow), possessed a larger pre-systolic KE than the other three flow components (p<0.01)(Figure 3). The Direct Flow had a larger volume than the other flow components (p<0.001), and was located mainly in the basal half of the ventricle (Figures 1 and 2). The Residual Volume was larger than the Delayed Ejection Flow (p<0.01) and the Retained Inflow (p<0.05), and was located mainly in the apical half of the ventricle (Figures 1 and 2).


Visualization and quantification of 4D blood flow distribution and energetics in the right ventricle
End-diastolic kinetic energy for the four right ventricular flow components in healthy subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3106535&req=5

Figure 3: End-diastolic kinetic energy for the four right ventricular flow components in healthy subjects.
Mentions: The portion of RV inflow passing directly to outflow (Direct Flow), possessed a larger pre-systolic KE than the other three flow components (p<0.01)(Figure 3). The Direct Flow had a larger volume than the other flow components (p<0.001), and was located mainly in the basal half of the ventricle (Figures 1 and 2). The Residual Volume was larger than the Delayed Ejection Flow (p<0.01) and the Retained Inflow (p<0.05), and was located mainly in the apical half of the ventricle (Figures 1 and 2).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Right ventricular (RV) function has important prognostic value in both right- and left-sided acquired and congenital heart diseases (1)... Assessment of RV function is challenging because of its complex crescent shaped geometry and load conditions being significantly influenced by respiration... Incremental insights into RV blood flow patterns have the potential to add to our understanding of RV function (2), but remain incompletely characterized... We hypothesized that a specific portion of the RV end-diastolic (ED) blood volume is prepared for effective systolic ejection and that this sub-volume can be identified based on its pre-systolic kinetic energy (KE) and location... Accordingly, the ED blood volume could be automatically separated into four functional flow components (3,4)(Figures 1 and 2)... The portion of RV inflow passing directly to outflow (Direct Flow), possessed a larger pre-systolic KE than the other three flow components (p<0.01)(Figure 3)... The Direct Flow had a larger volume than the other flow components (p<0.001), and was located mainly in the basal half of the ventricle (Figures 1 and 2)... The Residual Volume was larger than the Delayed Ejection Flow (p<0.01) and the Retained Inflow (p<0.05), and was located mainly in the apical half of the ventricle (Figures 1 and 2)... Semi-automatic analysis of 4D CMR velocity data allows separation of RV flow into distinct functional components... The present findings suggest that diastolic flow in the normal RV creates favorable conditions for effective systolic ejection, defined by pre-systolic KE and location, for the Direct Flow component... These flow-specific aspects of RV diastolic-systolic coupling may provide new useful perspectives on RV- and interventricular function in health and disease.

No MeSH data available.