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Integrated quantitative first-pass cardiac perfusion MRI protocol

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The proposed contrast-enhanced first-pass perfusion cardiovascular MR (CMR) protocol integrates some recent technical MRI advances towards quantitative analysis of perfusion CMR images: fast multi-slice pulse sequence, robust saturation pulse, accurate dedicated AIF imaging, signal-to-concentration modeling, and higher SNR at 3T... First-pass perfusion CMR was performed in 7 volunteers (0.05mmol/kg, Gd-DTPA)... Total image acquisition time was 523ms for the acquisition of 4 slices, namely aortic root and SA base, mid, and apex levels, with respective TD values 50-164-278-393ms... Contours for the blood and left ventricle were drawn manually, and the myocardium was divided into 6 (base-mid) or 4 (apex) standard segments... Representative images at peak contrast in blood and myocardium are shown Fig. 2, along with representative AIF and myocardial segment time-responses... The peak blood signal was not clipped in the short TD=50ms AIF images... Normalized signal in the myocardium increased along with TD; however similar [Gd-DTPA] were measured in all 3 short-axis images... The proposed integrated first-pass perfusion CMR protocol at 3T produced AIF and myocardial wall Gd-DTPA concentrations consistent with previously published results... Future work includes evaluation of the integrated protocol in cardiac patients.

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Representative images at peak blood and peak myocardium concentrations.
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Figure 2: Representative images at peak blood and peak myocardium concentrations.

Mentions: Representative images at peak contrast in blood and myocardium are shown Fig.2, along with representative AIF and myocardial segment time-responses. The peak blood signal was not clipped in the short TD=50ms AIF images. Normalized signal in the myocardium increased along with TD; however similar [Gd-DTPA] were measured in all 3 short-axis images. First-pass perfusion peak Gd-DTPA concentrations were 3.95±0.080, 0.26±0.07mM in the blood and myocardium, respectively.


Integrated quantitative first-pass cardiac perfusion MRI protocol
Representative images at peak blood and peak myocardium concentrations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3106533&req=5

Figure 2: Representative images at peak blood and peak myocardium concentrations.
Mentions: Representative images at peak contrast in blood and myocardium are shown Fig.2, along with representative AIF and myocardial segment time-responses. The peak blood signal was not clipped in the short TD=50ms AIF images. Normalized signal in the myocardium increased along with TD; however similar [Gd-DTPA] were measured in all 3 short-axis images. First-pass perfusion peak Gd-DTPA concentrations were 3.95±0.080, 0.26±0.07mM in the blood and myocardium, respectively.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The proposed contrast-enhanced first-pass perfusion cardiovascular MR (CMR) protocol integrates some recent technical MRI advances towards quantitative analysis of perfusion CMR images: fast multi-slice pulse sequence, robust saturation pulse, accurate dedicated AIF imaging, signal-to-concentration modeling, and higher SNR at 3T... First-pass perfusion CMR was performed in 7 volunteers (0.05mmol/kg, Gd-DTPA)... Total image acquisition time was 523ms for the acquisition of 4 slices, namely aortic root and SA base, mid, and apex levels, with respective TD values 50-164-278-393ms... Contours for the blood and left ventricle were drawn manually, and the myocardium was divided into 6 (base-mid) or 4 (apex) standard segments... Representative images at peak contrast in blood and myocardium are shown Fig. 2, along with representative AIF and myocardial segment time-responses... The peak blood signal was not clipped in the short TD=50ms AIF images... Normalized signal in the myocardium increased along with TD; however similar [Gd-DTPA] were measured in all 3 short-axis images... The proposed integrated first-pass perfusion CMR protocol at 3T produced AIF and myocardial wall Gd-DTPA concentrations consistent with previously published results... Future work includes evaluation of the integrated protocol in cardiac patients.

No MeSH data available.