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A T2* MRI prospective survey on heart iron in thalassemia major patients treated with sequential deferiprone-desferrioxamine versus deferipron and desferrioxamine in monotherapy

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Mentions: Excellent/good levels of compliance were similar in the 3 groups (DFP-DFO 96% versus DFP 97% versus DFO 92%; P=0.67). Among the patients with no significant myocardial iron overload (MIO) at baseline (global heart T2* ≥ 20 ms), there were no significant differences between groups to maintain the patients without MIO (DFP-DFO 95% versus DFP 100% versus DFO 100%; P=0.23). Among the patients with MIO at baseline (global heart T2* < 20 ms), only DFP and DFO showed a significant improvement in the global heart T2* value (P=0.001 and P=0.003, respectively) and in the number of segment with a normal T2* value (P=0.031 and P=0.0001, respectively). The improvement in the global heart T2* was significantly different among groups (mean difference global heart T2* DFP-DFO 2.2 ± 4.1 ms, DFP 10.7 ± 7.2, DFO 3.6 ± 5.4; P=0.007). The improvement in the global heart T2* was significantly lower in the DFP-DFO versus DFP group (P=0.014), but it was not significantly different in the DFP-DFO versus the DFO group (P=0.63) (see figure 1).


A T2* MRI prospective survey on heart iron in thalassemia major patients treated with sequential deferiprone-desferrioxamine versus deferipron and desferrioxamine in monotherapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3106517&req=5

Mentions: Excellent/good levels of compliance were similar in the 3 groups (DFP-DFO 96% versus DFP 97% versus DFO 92%; P=0.67). Among the patients with no significant myocardial iron overload (MIO) at baseline (global heart T2* ≥ 20 ms), there were no significant differences between groups to maintain the patients without MIO (DFP-DFO 95% versus DFP 100% versus DFO 100%; P=0.23). Among the patients with MIO at baseline (global heart T2* < 20 ms), only DFP and DFO showed a significant improvement in the global heart T2* value (P=0.001 and P=0.003, respectively) and in the number of segment with a normal T2* value (P=0.031 and P=0.0001, respectively). The improvement in the global heart T2* was significantly different among groups (mean difference global heart T2* DFP-DFO 2.2 ± 4.1 ms, DFP 10.7 ± 7.2, DFO 3.6 ± 5.4; P=0.007). The improvement in the global heart T2* was significantly lower in the DFP-DFO versus DFP group (P=0.014), but it was not significantly different in the DFP-DFO versus the DFO group (P=0.63) (see figure 1).

View Article: PubMed Central - HTML

No MeSH data available.