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Quantification of myocardial oxygen consumption with 17 O-CMR: initial study

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This study is aiming to develop a new non-invasive CMR method with the use of O based blood tracer to assess myocardial oxygenation and MVO2... The initial O-CMR was performed in normal mongrel dogs (n=3) and myocardial ischemic dogs (n=3)... The later dogs includes 70% (n=1) and 100% (n=2) area stenosis in the second diagonal branch of the left descending coronary artery (LAD)... The H2O water concentration can be obtained with the ratio between T1ρ-weighted signals after and before the O-PFD injection... MVO2 can be quantified using a new model developed in our laboratory... Quantitative perfusion CMR imaging was also performed at the end of study to confirm the ischemic area... The averaged MVO2 in the anterior myocardial region of three normal dogs was 3.96 ± 0.97 μmol/g/min, which agrees well with MVO2 measured by PET in mongrel dogs... For the 70% stenotic dog, the MVO2 was 2.84 μmol/g/min in the anterior region (normal LAD perfused segment) and 1.57 μmol/g/min in the lateral region (the diagonal branch of LAD perfused segment), respectively (Figure 1)... Figure 2 shows quantitative perfusion map and a post-T1p-weighted image in a dog with the 100% stenosis, indicating that oxygen deficit area appeared to be smaller than hypo-perfusion size... The O-CMR may have potential to provide a direct and non-invasive measurement of the oxygen consumption to facilitate comprehensive evaluations of patients at molecular level with a variety of pathophysiological etiologies.

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Quantitative myocardial perfusion map of a 70% stenosis (left panel). The converted [H217O] curve (right panel) shows elevated [H217O] levels in LAD and suppressed [H217O] in lateral region. The lines in this plot indicate fitted data from our model.
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Figure 1: Quantitative myocardial perfusion map of a 70% stenosis (left panel). The converted [H217O] curve (right panel) shows elevated [H217O] levels in LAD and suppressed [H217O] in lateral region. The lines in this plot indicate fitted data from our model.

Mentions: The averaged MVO2 in the anterior myocardial region of three normal dogs was 3.96 ± 0.97 μmol/g/min, which agrees well with MVO2 measured by PET in mongrel dogs. For the 70% stenotic dog, the MVO2 was 2.84 μmol/g/min in the anterior region (normal LAD perfused segment) and 1.57 μmol/g/min in the lateral region (the diagonal branch of LAD perfused segment), respectively (Figure 1). Figure 2 shows quantitative perfusion map and a post-T1p-weighted image in a dog with the 100% stenosis, indicating that oxygen deficit area appeared to be smaller than hypo-perfusion size.


Quantification of myocardial oxygen consumption with 17 O-CMR: initial study
Quantitative myocardial perfusion map of a 70% stenosis (left panel). The converted [H217O] curve (right panel) shows elevated [H217O] levels in LAD and suppressed [H217O] in lateral region. The lines in this plot indicate fitted data from our model.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3106488&req=5

Figure 1: Quantitative myocardial perfusion map of a 70% stenosis (left panel). The converted [H217O] curve (right panel) shows elevated [H217O] levels in LAD and suppressed [H217O] in lateral region. The lines in this plot indicate fitted data from our model.
Mentions: The averaged MVO2 in the anterior myocardial region of three normal dogs was 3.96 ± 0.97 μmol/g/min, which agrees well with MVO2 measured by PET in mongrel dogs. For the 70% stenotic dog, the MVO2 was 2.84 μmol/g/min in the anterior region (normal LAD perfused segment) and 1.57 μmol/g/min in the lateral region (the diagonal branch of LAD perfused segment), respectively (Figure 1). Figure 2 shows quantitative perfusion map and a post-T1p-weighted image in a dog with the 100% stenosis, indicating that oxygen deficit area appeared to be smaller than hypo-perfusion size.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

This study is aiming to develop a new non-invasive CMR method with the use of O based blood tracer to assess myocardial oxygenation and MVO2... The initial O-CMR was performed in normal mongrel dogs (n=3) and myocardial ischemic dogs (n=3)... The later dogs includes 70% (n=1) and 100% (n=2) area stenosis in the second diagonal branch of the left descending coronary artery (LAD)... The H2O water concentration can be obtained with the ratio between T1ρ-weighted signals after and before the O-PFD injection... MVO2 can be quantified using a new model developed in our laboratory... Quantitative perfusion CMR imaging was also performed at the end of study to confirm the ischemic area... The averaged MVO2 in the anterior myocardial region of three normal dogs was 3.96 ± 0.97 μmol/g/min, which agrees well with MVO2 measured by PET in mongrel dogs... For the 70% stenotic dog, the MVO2 was 2.84 μmol/g/min in the anterior region (normal LAD perfused segment) and 1.57 μmol/g/min in the lateral region (the diagonal branch of LAD perfused segment), respectively (Figure 1)... Figure 2 shows quantitative perfusion map and a post-T1p-weighted image in a dog with the 100% stenosis, indicating that oxygen deficit area appeared to be smaller than hypo-perfusion size... The O-CMR may have potential to provide a direct and non-invasive measurement of the oxygen consumption to facilitate comprehensive evaluations of patients at molecular level with a variety of pathophysiological etiologies.

No MeSH data available.


Related in: MedlinePlus