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Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?

Kong D, Li Y, Wang Z, Sarkar FH - Cancers (Basel) (2011)

Bottom Line: Although the cell origin of CSCs remains to be fully elucidated, mounting evidence has demonstrated that Epithelial-to-Mesenchymal Transition (EMT), induced by different factors, is associated with tumor aggressiveness and metastasis and these cells share molecular characteristics with CSCs, and thus are often called cancer stem-like cells or tumor-initiating cells.The acquisition of an EMT phenotype is a critical process for switching early stage carcinomas into invasive malignancies, which is often associated with the loss of epithelial differentiation and gain of mesenchymal phenotype.Here we will succinctly summarize the state-of-our-knowledge regarding the molecular similarities between cancer stem-like cells or CSCs and EMT-phenotypic cells that are associated with tumor aggressiveness focusing on solid tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI 48201, USA.

ABSTRACT
Cancer stem cells (CSCs) are cells within a tumor that possess the capacity to self-renew and maintain tumor-initiating capacity through differentiation into the heterogeneous lineages of cancer cells that comprise the whole tumor. These tumor-initiating cells could provide a resource for cells that cause tumor recurrence after therapy. Although the cell origin of CSCs remains to be fully elucidated, mounting evidence has demonstrated that Epithelial-to-Mesenchymal Transition (EMT), induced by different factors, is associated with tumor aggressiveness and metastasis and these cells share molecular characteristics with CSCs, and thus are often called cancer stem-like cells or tumor-initiating cells. The acquisition of an EMT phenotype is a critical process for switching early stage carcinomas into invasive malignancies, which is often associated with the loss of epithelial differentiation and gain of mesenchymal phenotype. Recent studies have demonstrated that EMT plays a critical role not only in tumor metastasis but also in tumor recurrence and that it is tightly linked with the biology of cancer stem-like cells or cancer-initiating cells. Here we will succinctly summarize the state-of-our-knowledge regarding the molecular similarities between cancer stem-like cells or CSCs and EMT-phenotypic cells that are associated with tumor aggressiveness focusing on solid tumors.

No MeSH data available.


Related in: MedlinePlus

Induction of epithelial-to-mesenchymal transition (EMT)-phenotypic cells produces cancer stem-like cells with drug-resistant characteristics. Growth factors, including FGF, EGF, PDGF-B and PDGF-D as well as factors such as TGF-β, Notch-1 and Wnt, can induce EMT, while miR-200 family inhibits EMT by regulating the expression of transcription repressors ZEB1 and ZEB2. EMT-phenotypic cells acquire stem-like cell signatures characterized by increased metastatic capacity, self-renewal ability and acquired drug resistance. These cells metastasize to distant sites and undergo MET to produce metastatic tumors that are phenotypically similar to the primary tumor.
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f1-cancers-03-00716: Induction of epithelial-to-mesenchymal transition (EMT)-phenotypic cells produces cancer stem-like cells with drug-resistant characteristics. Growth factors, including FGF, EGF, PDGF-B and PDGF-D as well as factors such as TGF-β, Notch-1 and Wnt, can induce EMT, while miR-200 family inhibits EMT by regulating the expression of transcription repressors ZEB1 and ZEB2. EMT-phenotypic cells acquire stem-like cell signatures characterized by increased metastatic capacity, self-renewal ability and acquired drug resistance. These cells metastasize to distant sites and undergo MET to produce metastatic tumors that are phenotypically similar to the primary tumor.

Mentions: Mounting evidence has shown that induction of EMT by different factors could generate stem-like cells characterized by enhanced self-renewal and invasive capacity and high drug resistance, which is strongly associated with metastases and recurrence of tumors (Figure 1).


Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?

Kong D, Li Y, Wang Z, Sarkar FH - Cancers (Basel) (2011)

Induction of epithelial-to-mesenchymal transition (EMT)-phenotypic cells produces cancer stem-like cells with drug-resistant characteristics. Growth factors, including FGF, EGF, PDGF-B and PDGF-D as well as factors such as TGF-β, Notch-1 and Wnt, can induce EMT, while miR-200 family inhibits EMT by regulating the expression of transcription repressors ZEB1 and ZEB2. EMT-phenotypic cells acquire stem-like cell signatures characterized by increased metastatic capacity, self-renewal ability and acquired drug resistance. These cells metastasize to distant sites and undergo MET to produce metastatic tumors that are phenotypically similar to the primary tumor.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3106306&req=5

f1-cancers-03-00716: Induction of epithelial-to-mesenchymal transition (EMT)-phenotypic cells produces cancer stem-like cells with drug-resistant characteristics. Growth factors, including FGF, EGF, PDGF-B and PDGF-D as well as factors such as TGF-β, Notch-1 and Wnt, can induce EMT, while miR-200 family inhibits EMT by regulating the expression of transcription repressors ZEB1 and ZEB2. EMT-phenotypic cells acquire stem-like cell signatures characterized by increased metastatic capacity, self-renewal ability and acquired drug resistance. These cells metastasize to distant sites and undergo MET to produce metastatic tumors that are phenotypically similar to the primary tumor.
Mentions: Mounting evidence has shown that induction of EMT by different factors could generate stem-like cells characterized by enhanced self-renewal and invasive capacity and high drug resistance, which is strongly associated with metastases and recurrence of tumors (Figure 1).

Bottom Line: Although the cell origin of CSCs remains to be fully elucidated, mounting evidence has demonstrated that Epithelial-to-Mesenchymal Transition (EMT), induced by different factors, is associated with tumor aggressiveness and metastasis and these cells share molecular characteristics with CSCs, and thus are often called cancer stem-like cells or tumor-initiating cells.The acquisition of an EMT phenotype is a critical process for switching early stage carcinomas into invasive malignancies, which is often associated with the loss of epithelial differentiation and gain of mesenchymal phenotype.Here we will succinctly summarize the state-of-our-knowledge regarding the molecular similarities between cancer stem-like cells or CSCs and EMT-phenotypic cells that are associated with tumor aggressiveness focusing on solid tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI 48201, USA.

ABSTRACT
Cancer stem cells (CSCs) are cells within a tumor that possess the capacity to self-renew and maintain tumor-initiating capacity through differentiation into the heterogeneous lineages of cancer cells that comprise the whole tumor. These tumor-initiating cells could provide a resource for cells that cause tumor recurrence after therapy. Although the cell origin of CSCs remains to be fully elucidated, mounting evidence has demonstrated that Epithelial-to-Mesenchymal Transition (EMT), induced by different factors, is associated with tumor aggressiveness and metastasis and these cells share molecular characteristics with CSCs, and thus are often called cancer stem-like cells or tumor-initiating cells. The acquisition of an EMT phenotype is a critical process for switching early stage carcinomas into invasive malignancies, which is often associated with the loss of epithelial differentiation and gain of mesenchymal phenotype. Recent studies have demonstrated that EMT plays a critical role not only in tumor metastasis but also in tumor recurrence and that it is tightly linked with the biology of cancer stem-like cells or cancer-initiating cells. Here we will succinctly summarize the state-of-our-knowledge regarding the molecular similarities between cancer stem-like cells or CSCs and EMT-phenotypic cells that are associated with tumor aggressiveness focusing on solid tumors.

No MeSH data available.


Related in: MedlinePlus