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Serotonergic contribution to boys' behavioral regulation.

Nantel-Vivier A, Pihl RO, Young SN, Parent S, Bélanger SA, Sutton R, Dubois ME, Tremblay RE, Séguin JR - PLoS ONE (2011)

Bottom Line: However, boys in the tryptophan group adjusted their level of responding optimally as a function of the level of provocation, whereas boys in the control group significantly decreased their level of responding towards the end of the competition.Boys in the tryptophan group tended to show greater perspective taking, tended to better distinguish facial expressions of fear and happiness, and tended to provide greater instrumental help to the experimenter.The present study provides initial evidence for the feasibility of acute tryptophan supplementation in children and some effect of tryptophan supplementation on children's behaviors.

View Article: PubMed Central - PubMed

Affiliation: Psychology Department, McGill University, Montreal, Canada.

ABSTRACT

Objectives: Animal and human adult studies reveal a contribution of serotonin to behavior regulation. Whether these findings apply to children is unclear. The present study investigated serotonergic functioning in boys with a history of behavior regulation difficulties through a double-blind, acute tryptophan supplementation procedure.

Method: Participants were 23 boys (age 10 years) with a history of elevated physical aggression, recruited from a community sample. Eleven were given a chocolate milkshake supplemented with 500 mg tryptophan, and 12 received a chocolate milkshake without tryptophan. Boys engaged in a competitive reaction time game against a fictitious opponent, which assessed response to provocation, impulsivity, perspective taking, and sharing. Impulsivity was further assessed through a Go/No-Go paradigm. A computerized emotion recognition task and a staged instrumental help incident were also administered.

Results: Boys, regardless of group, responded similarly to high provocation by the fictitious opponent. However, boys in the tryptophan group adjusted their level of responding optimally as a function of the level of provocation, whereas boys in the control group significantly decreased their level of responding towards the end of the competition. Boys in the tryptophan group tended to show greater perspective taking, tended to better distinguish facial expressions of fear and happiness, and tended to provide greater instrumental help to the experimenter.

Conclusions: The present study provides initial evidence for the feasibility of acute tryptophan supplementation in children and some effect of tryptophan supplementation on children's behaviors. Further studies are warranted to explore the potential impact of increased serotonergic functioning on boys' dominant and affiliative behaviors.

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Perspective taking following the competitive reaction time game.Fisher's exact test (p = 0.07).
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pone-0020304-g003: Perspective taking following the competitive reaction time game.Fisher's exact test (p = 0.07).

Mentions: As shown in Table 1, no significant group differences emerged for the percentage of points shared with the fictitious opponent at the end of the game. However, Figure 3 shows a trend for boys in the tryptophan group to be less likely to describe their defeated opponent as emotionally neutral, and instead tend to describe the opponent as experiencing a negative emotional state (Fisher's exact test, p = 0.07).


Serotonergic contribution to boys' behavioral regulation.

Nantel-Vivier A, Pihl RO, Young SN, Parent S, Bélanger SA, Sutton R, Dubois ME, Tremblay RE, Séguin JR - PLoS ONE (2011)

Perspective taking following the competitive reaction time game.Fisher's exact test (p = 0.07).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3105989&req=5

pone-0020304-g003: Perspective taking following the competitive reaction time game.Fisher's exact test (p = 0.07).
Mentions: As shown in Table 1, no significant group differences emerged for the percentage of points shared with the fictitious opponent at the end of the game. However, Figure 3 shows a trend for boys in the tryptophan group to be less likely to describe their defeated opponent as emotionally neutral, and instead tend to describe the opponent as experiencing a negative emotional state (Fisher's exact test, p = 0.07).

Bottom Line: However, boys in the tryptophan group adjusted their level of responding optimally as a function of the level of provocation, whereas boys in the control group significantly decreased their level of responding towards the end of the competition.Boys in the tryptophan group tended to show greater perspective taking, tended to better distinguish facial expressions of fear and happiness, and tended to provide greater instrumental help to the experimenter.The present study provides initial evidence for the feasibility of acute tryptophan supplementation in children and some effect of tryptophan supplementation on children's behaviors.

View Article: PubMed Central - PubMed

Affiliation: Psychology Department, McGill University, Montreal, Canada.

ABSTRACT

Objectives: Animal and human adult studies reveal a contribution of serotonin to behavior regulation. Whether these findings apply to children is unclear. The present study investigated serotonergic functioning in boys with a history of behavior regulation difficulties through a double-blind, acute tryptophan supplementation procedure.

Method: Participants were 23 boys (age 10 years) with a history of elevated physical aggression, recruited from a community sample. Eleven were given a chocolate milkshake supplemented with 500 mg tryptophan, and 12 received a chocolate milkshake without tryptophan. Boys engaged in a competitive reaction time game against a fictitious opponent, which assessed response to provocation, impulsivity, perspective taking, and sharing. Impulsivity was further assessed through a Go/No-Go paradigm. A computerized emotion recognition task and a staged instrumental help incident were also administered.

Results: Boys, regardless of group, responded similarly to high provocation by the fictitious opponent. However, boys in the tryptophan group adjusted their level of responding optimally as a function of the level of provocation, whereas boys in the control group significantly decreased their level of responding towards the end of the competition. Boys in the tryptophan group tended to show greater perspective taking, tended to better distinguish facial expressions of fear and happiness, and tended to provide greater instrumental help to the experimenter.

Conclusions: The present study provides initial evidence for the feasibility of acute tryptophan supplementation in children and some effect of tryptophan supplementation on children's behaviors. Further studies are warranted to explore the potential impact of increased serotonergic functioning on boys' dominant and affiliative behaviors.

Show MeSH
Related in: MedlinePlus