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Semantics-based composition of EMBOSS services.

Lamprecht AL, Naujokat S, Margaria T, Steffen B - J Biomed Semantics (2011)

Bottom Line: Our experiments demonstrate that these domain models in combination with our synthesis methodology greatly simplify working with the large, heterogeneous, and hence manually intractable EMBOSS collection.However, they also show that with the information that can be derived from the (current) ACD files and EDAM ontology alone, some essential connections between services can not be recognized.Our results show that adequate domain modeling requires to incorporate as much domain knowledge as possible, far beyond the mere technical aspects of the different types and services.

View Article: PubMed Central - HTML - PubMed

Affiliation: Chair for Programming Systems, Technical University Dortmund, Dortmund, D-44227, Germany. anna-lena.lamprecht@cs.tu-dortmund.de.

ABSTRACT

Background: More than in other domains the heterogeneous services world in bioinformatics demands for a methodology to classify and relate resources in a both human and machine accessible manner. The Semantic Web, which is meant to address exactly this challenge, is currently one of the most ambitious projects in computer science. Collective efforts within the community have already led to a basis of standards for semantic service descriptions and meta-information. In combination with process synthesis and planning methods, such knowledge about types and services can facilitate the automatic composition of workflows for particular research questions.

Results: In this study we apply the synthesis methodology that is available in the Bio-jETI workflow management framework for the semantics-based composition of EMBOSS services. EMBOSS (European Molecular Biology Open Software Suite) is a collection of 350 tools (March 2010) for various sequence analysis tasks, and thus a rich source of services and types that imply comprehensive domain models for planning and synthesis approaches. We use and compare two different setups of our EMBOSS synthesis domain: 1) a manually defined domain setup where an intuitive, high-level, semantically meaningful nomenclature is applied to describe the input/output behavior of the single EMBOSS tools and their classifications, and 2) a domain setup where this information has been automatically derived from the EMBOSS Ajax Command Definition (ACD) files and the EMBRACE Data and Methods ontology (EDAM). Our experiments demonstrate that these domain models in combination with our synthesis methodology greatly simplify working with the large, heterogeneous, and hence manually intractable EMBOSS collection. However, they also show that with the information that can be derived from the (current) ACD files and EDAM ontology alone, some essential connections between services can not be recognized.

Conclusions: Our results show that adequate domain modeling requires to incorporate as much domain knowledge as possible, far beyond the mere technical aspects of the different types and services. Finding or defining semantically appropriate service and type descriptions is a difficult task, but the bioinformatics community appears to be on the right track towards a Life Science Semantic Web, which will eventually allow automatic service composition methods to unfold their full potential.

No MeSH data available.


Related in: MedlinePlus

Manually defined service taxonomy for the HMMER subset of the EMBOSS domain. This taxonomy contains four abstract groups.								 Edit							 has the services								 makenucseq							 and								 makeprotseq							 as instances, the services								 showseq, showalign							 and								 showtext							 are classified as								 Display							 by the taxonomy. 								Edialign							 and								 emma							 are abstractly described as								 AlignmentMultiple,							 the remaining tools belong to the								 HMM							 group.
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Figure 1: Manually defined service taxonomy for the HMMER subset of the EMBOSS domain. This taxonomy contains four abstract groups. Edit has the services makenucseq and makeprotseq as instances, the services showseq, showalign and showtext are classified as Display by the taxonomy. Edialign and emma are abstractly described as AlignmentMultiple, the remaining tools belong to the HMM group.

Mentions: Figure 1 shows the manually defined service taxonomy for the HMMER subset, the type taxonomy is given in Figure 2. The (blue) squares in the figure represent the abstract services or types (OWL classes), and the (purple) rhombs are used for concrete instances (OWL individuals). The generic type Thing (center) represents the root of the taxonomy, underneath which abstract groups are defined. The service taxonomy (Figure 1) contains four abstract groups. Edit has the services makenucseq and makeprotseq as instances, and the services showseq, showalign and showtext are classified as Display by the taxonomy. Edialign and emma are abstractly described as AlignmentMultiple, the remaining tools belong to the HMM group. Although it would be natural to classify the HMM tools further (e.g., ehmmalign is also an Alignment service), we leave it this simple for presentation in this paper, as a further classification is not relevant for the given examples. As all services in the HMMER subset work on text-based data, all available types in the type taxonomy (Figure 2) belong to the Text group. The different Sequence types are distinguished further into the groups ProteinSequence, NucleotideSequence, and MultipleSequence. Note that some types are instances of more than one group: MultipleNucleotideSequence, for instance, is both a MultipleSequence and NucleotideSequence.


Semantics-based composition of EMBOSS services.

Lamprecht AL, Naujokat S, Margaria T, Steffen B - J Biomed Semantics (2011)

Manually defined service taxonomy for the HMMER subset of the EMBOSS domain. This taxonomy contains four abstract groups.								 Edit							 has the services								 makenucseq							 and								 makeprotseq							 as instances, the services								 showseq, showalign							 and								 showtext							 are classified as								 Display							 by the taxonomy. 								Edialign							 and								 emma							 are abstractly described as								 AlignmentMultiple,							 the remaining tools belong to the								 HMM							 group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3105497&req=5

Figure 1: Manually defined service taxonomy for the HMMER subset of the EMBOSS domain. This taxonomy contains four abstract groups. Edit has the services makenucseq and makeprotseq as instances, the services showseq, showalign and showtext are classified as Display by the taxonomy. Edialign and emma are abstractly described as AlignmentMultiple, the remaining tools belong to the HMM group.
Mentions: Figure 1 shows the manually defined service taxonomy for the HMMER subset, the type taxonomy is given in Figure 2. The (blue) squares in the figure represent the abstract services or types (OWL classes), and the (purple) rhombs are used for concrete instances (OWL individuals). The generic type Thing (center) represents the root of the taxonomy, underneath which abstract groups are defined. The service taxonomy (Figure 1) contains four abstract groups. Edit has the services makenucseq and makeprotseq as instances, and the services showseq, showalign and showtext are classified as Display by the taxonomy. Edialign and emma are abstractly described as AlignmentMultiple, the remaining tools belong to the HMM group. Although it would be natural to classify the HMM tools further (e.g., ehmmalign is also an Alignment service), we leave it this simple for presentation in this paper, as a further classification is not relevant for the given examples. As all services in the HMMER subset work on text-based data, all available types in the type taxonomy (Figure 2) belong to the Text group. The different Sequence types are distinguished further into the groups ProteinSequence, NucleotideSequence, and MultipleSequence. Note that some types are instances of more than one group: MultipleNucleotideSequence, for instance, is both a MultipleSequence and NucleotideSequence.

Bottom Line: Our experiments demonstrate that these domain models in combination with our synthesis methodology greatly simplify working with the large, heterogeneous, and hence manually intractable EMBOSS collection.However, they also show that with the information that can be derived from the (current) ACD files and EDAM ontology alone, some essential connections between services can not be recognized.Our results show that adequate domain modeling requires to incorporate as much domain knowledge as possible, far beyond the mere technical aspects of the different types and services.

View Article: PubMed Central - HTML - PubMed

Affiliation: Chair for Programming Systems, Technical University Dortmund, Dortmund, D-44227, Germany. anna-lena.lamprecht@cs.tu-dortmund.de.

ABSTRACT

Background: More than in other domains the heterogeneous services world in bioinformatics demands for a methodology to classify and relate resources in a both human and machine accessible manner. The Semantic Web, which is meant to address exactly this challenge, is currently one of the most ambitious projects in computer science. Collective efforts within the community have already led to a basis of standards for semantic service descriptions and meta-information. In combination with process synthesis and planning methods, such knowledge about types and services can facilitate the automatic composition of workflows for particular research questions.

Results: In this study we apply the synthesis methodology that is available in the Bio-jETI workflow management framework for the semantics-based composition of EMBOSS services. EMBOSS (European Molecular Biology Open Software Suite) is a collection of 350 tools (March 2010) for various sequence analysis tasks, and thus a rich source of services and types that imply comprehensive domain models for planning and synthesis approaches. We use and compare two different setups of our EMBOSS synthesis domain: 1) a manually defined domain setup where an intuitive, high-level, semantically meaningful nomenclature is applied to describe the input/output behavior of the single EMBOSS tools and their classifications, and 2) a domain setup where this information has been automatically derived from the EMBOSS Ajax Command Definition (ACD) files and the EMBRACE Data and Methods ontology (EDAM). Our experiments demonstrate that these domain models in combination with our synthesis methodology greatly simplify working with the large, heterogeneous, and hence manually intractable EMBOSS collection. However, they also show that with the information that can be derived from the (current) ACD files and EDAM ontology alone, some essential connections between services can not be recognized.

Conclusions: Our results show that adequate domain modeling requires to incorporate as much domain knowledge as possible, far beyond the mere technical aspects of the different types and services. Finding or defining semantically appropriate service and type descriptions is a difficult task, but the bioinformatics community appears to be on the right track towards a Life Science Semantic Web, which will eventually allow automatic service composition methods to unfold their full potential.

No MeSH data available.


Related in: MedlinePlus