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Single-molecule identification via electric current noise.

Tsutsui M, Taniguchi M, Kawai T - Nat Commun (2010)

Bottom Line: Label-free and real-time single-molecule detection may aid the development of high-throughput biosensing platforms.We found increased current oscillations synchronous to electric field excitations of characteristic molecular vibrational modes that contribute to inelastic electron tunnelling.This finding demonstrates a large contribution of charge interaction with nuclear dynamics on noise properties of single-molecule bridges and suggests a potential use of inelastic noise as a valuable molecular signature for single-molecule identification.

View Article: PubMed Central - PubMed

Affiliation: The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.

ABSTRACT
Label-free and real-time single-molecule detection may aid the development of high-throughput biosensing platforms. Molecular fluctuations are a source of noise that often hinders single-molecule identification by obscuring the fine details of molecular identity. In this study, we report molecular identification through direct observation of quantum-fluctuation-induced inelastic noise in single organic molecules. We investigated current fluctuations flowing through a single molecule that is chemically connected to two electrodes. We found increased current oscillations synchronous to electric field excitations of characteristic molecular vibrational modes that contribute to inelastic electron tunnelling. This finding demonstrates a large contribution of charge interaction with nuclear dynamics on noise properties of single-molecule bridges and suggests a potential use of inelastic noise as a valuable molecular signature for single-molecule identification.

No MeSH data available.


Related in: MedlinePlus

A peak voltage histogram constructed with Vp data extracted from the σ spectra of 41 HDT single-molecule junctions formed at 4.2 K.Peaks are numbered as 1–6 and 1′–6′ in the positive and the negative side, respectively.
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f3: A peak voltage histogram constructed with Vp data extracted from the σ spectra of 41 HDT single-molecule junctions formed at 4.2 K.Peaks are numbered as 1–6 and 1′–6′ in the positive and the negative side, respectively.

Mentions: We examined the reproducibility of the characteristic σ steps by statistically analysing σ–Vb characteristics for 41 HDT single-molecule bridges at 1.3 mG0. A histogram constructed with Vp data extracted from the σ spectrum of single HDT molecules contains several peaks at almost symmetric positions with respect to zero bias (Fig. 3). As we see in Table 2, the statistical Vp distribution fairly reproduces the σ spectrum shown in Figure 2e.


Single-molecule identification via electric current noise.

Tsutsui M, Taniguchi M, Kawai T - Nat Commun (2010)

A peak voltage histogram constructed with Vp data extracted from the σ spectra of 41 HDT single-molecule junctions formed at 4.2 K.Peaks are numbered as 1–6 and 1′–6′ in the positive and the negative side, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3105297&req=5

f3: A peak voltage histogram constructed with Vp data extracted from the σ spectra of 41 HDT single-molecule junctions formed at 4.2 K.Peaks are numbered as 1–6 and 1′–6′ in the positive and the negative side, respectively.
Mentions: We examined the reproducibility of the characteristic σ steps by statistically analysing σ–Vb characteristics for 41 HDT single-molecule bridges at 1.3 mG0. A histogram constructed with Vp data extracted from the σ spectrum of single HDT molecules contains several peaks at almost symmetric positions with respect to zero bias (Fig. 3). As we see in Table 2, the statistical Vp distribution fairly reproduces the σ spectrum shown in Figure 2e.

Bottom Line: Label-free and real-time single-molecule detection may aid the development of high-throughput biosensing platforms.We found increased current oscillations synchronous to electric field excitations of characteristic molecular vibrational modes that contribute to inelastic electron tunnelling.This finding demonstrates a large contribution of charge interaction with nuclear dynamics on noise properties of single-molecule bridges and suggests a potential use of inelastic noise as a valuable molecular signature for single-molecule identification.

View Article: PubMed Central - PubMed

Affiliation: The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.

ABSTRACT
Label-free and real-time single-molecule detection may aid the development of high-throughput biosensing platforms. Molecular fluctuations are a source of noise that often hinders single-molecule identification by obscuring the fine details of molecular identity. In this study, we report molecular identification through direct observation of quantum-fluctuation-induced inelastic noise in single organic molecules. We investigated current fluctuations flowing through a single molecule that is chemically connected to two electrodes. We found increased current oscillations synchronous to electric field excitations of characteristic molecular vibrational modes that contribute to inelastic electron tunnelling. This finding demonstrates a large contribution of charge interaction with nuclear dynamics on noise properties of single-molecule bridges and suggests a potential use of inelastic noise as a valuable molecular signature for single-molecule identification.

No MeSH data available.


Related in: MedlinePlus