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Scaling behavior of human locomotor activity amplitude: association with bipolar disorder.

Indic P, Salvatore P, Maggini C, Ghidini S, Ferraro G, Baldessarini RJ, Murray G - PLoS ONE (2011)

Bottom Line: Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology.The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity.A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America. Premananda.Indic@umassmed.edu

ABSTRACT
Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

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Related in: MedlinePlus

Estimated means (±SEM) computed vulnerability index (VI) values in four groups of human subjects of increasing risk or presence of BD.Low risk by GBI criteria (n = 35), healthy controls (n = 15), high-risk by GBI criteria (n = 35), and patients diagnosed with DSM-IV type-I BD who are currently clinically stable or euthymic (n = 15). Curve-fitting found that mean VI increased linearly across these groups (F [df = 3; 94] = 4.28, p = 0.007, controlling for sex and age).
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pone-0020650-g004: Estimated means (±SEM) computed vulnerability index (VI) values in four groups of human subjects of increasing risk or presence of BD.Low risk by GBI criteria (n = 35), healthy controls (n = 15), high-risk by GBI criteria (n = 35), and patients diagnosed with DSM-IV type-I BD who are currently clinically stable or euthymic (n = 15). Curve-fitting found that mean VI increased linearly across these groups (F [df = 3; 94] = 4.28, p = 0.007, controlling for sex and age).

Mentions: When all subjects from Studies 1 and 2 were included in a multivariate linear regression modelling, with GBI score as the dependent measure, and controlling for sex and age, the VI score was significantly and independently associated with either high risk for, or diagnosis of BD, and was the only factor associated (F [df = 3; 96] = 4.94, p = 0.001). Likewise, we found a significant linear trend in the mean magnitude of VI measures, ranking: low-GBI score < healthy controls ≤ non-BD patients with high GBI scores < BD patients (Figure 4), with control for sex and age (F [df = 3; 94] = 4.28, p = 0.007, β = 0.32, p = 0.01).


Scaling behavior of human locomotor activity amplitude: association with bipolar disorder.

Indic P, Salvatore P, Maggini C, Ghidini S, Ferraro G, Baldessarini RJ, Murray G - PLoS ONE (2011)

Estimated means (±SEM) computed vulnerability index (VI) values in four groups of human subjects of increasing risk or presence of BD.Low risk by GBI criteria (n = 35), healthy controls (n = 15), high-risk by GBI criteria (n = 35), and patients diagnosed with DSM-IV type-I BD who are currently clinically stable or euthymic (n = 15). Curve-fitting found that mean VI increased linearly across these groups (F [df = 3; 94] = 4.28, p = 0.007, controlling for sex and age).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3105113&req=5

pone-0020650-g004: Estimated means (±SEM) computed vulnerability index (VI) values in four groups of human subjects of increasing risk or presence of BD.Low risk by GBI criteria (n = 35), healthy controls (n = 15), high-risk by GBI criteria (n = 35), and patients diagnosed with DSM-IV type-I BD who are currently clinically stable or euthymic (n = 15). Curve-fitting found that mean VI increased linearly across these groups (F [df = 3; 94] = 4.28, p = 0.007, controlling for sex and age).
Mentions: When all subjects from Studies 1 and 2 were included in a multivariate linear regression modelling, with GBI score as the dependent measure, and controlling for sex and age, the VI score was significantly and independently associated with either high risk for, or diagnosis of BD, and was the only factor associated (F [df = 3; 96] = 4.94, p = 0.001). Likewise, we found a significant linear trend in the mean magnitude of VI measures, ranking: low-GBI score < healthy controls ≤ non-BD patients with high GBI scores < BD patients (Figure 4), with control for sex and age (F [df = 3; 94] = 4.28, p = 0.007, β = 0.32, p = 0.01).

Bottom Line: Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology.The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity.A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America. Premananda.Indic@umassmed.edu

ABSTRACT
Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

Show MeSH
Related in: MedlinePlus