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The transit phase of migration: circulation of malaria and its multidrug-resistant forms in Africa.

Lynch C, Roper C - PLoS Med. (2011)

View Article: PubMed Central - PubMed

Affiliation: London School of Hygiene and Tropical Medicine, London, UK.

ABSTRACT

Movement of people is the means by which human pathogens are dispersed, so providing health care to mobile sectors of the community is vital to disease control interventions.

Using malaria as a case study, our article examines types of migrant transit and their significance for prevention and treatment of the disease.

Asymptomatic untreated infections act as reservoirs for malaria transmission. Malaria control programmes need to identify those migrant streams with potential to transport malaria and to target prevention and treatment measures appropriately.

Transit has also played a role in the dispersal of antimalarial drug resistance, with the international transportation of artemisinin-resistant parasites by human migration being the greatest threat to the antimalarial treatments used in Africa today.

A geographic framework of human migration at local, national, and international levels is needed so the potential speed and direction of pathogen dispersal can be predicted, and for health policy and services to respond appropriately to the needs of migrants and to threats of pandemic.

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Related in: MedlinePlus

The complex patterns of migration flow in Uganda.The area of highly drug-resistant malaria is shown in red, major population                        migration flows are shown by arrows, major refugee camps are hatched, and                        the major urban population in Kampala is indicated in pink. The permanent                        migration streams are estimated from birthplace data from 1969 population                        census from Goddard [37].
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pmed-1001040-g002: The complex patterns of migration flow in Uganda.The area of highly drug-resistant malaria is shown in red, major population migration flows are shown by arrows, major refugee camps are hatched, and the major urban population in Kampala is indicated in pink. The permanent migration streams are estimated from birthplace data from 1969 population census from Goddard [37].

Mentions: There has emerged a highly resistant form of P. falciparum in the Kabale and Rukungiri districts of southwest Uganda [15] and in bordering areas of Rwanda [16]. The form carries a mutation in the dhfr gene, which confers high level resistance to a number of antifolate drugs in general use (including sulfadoxine-pyrimethamine and chlorproguanil-dapsone). To predict the likely path of dispersal of this resistant form of the parasite, we examined the types and frequency of population movements in Uganda. The region of resistance emergence is shown in red in Figure 2.


The transit phase of migration: circulation of malaria and its multidrug-resistant forms in Africa.

Lynch C, Roper C - PLoS Med. (2011)

The complex patterns of migration flow in Uganda.The area of highly drug-resistant malaria is shown in red, major population                        migration flows are shown by arrows, major refugee camps are hatched, and                        the major urban population in Kampala is indicated in pink. The permanent                        migration streams are estimated from birthplace data from 1969 population                        census from Goddard [37].
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3104977&req=5

pmed-1001040-g002: The complex patterns of migration flow in Uganda.The area of highly drug-resistant malaria is shown in red, major population migration flows are shown by arrows, major refugee camps are hatched, and the major urban population in Kampala is indicated in pink. The permanent migration streams are estimated from birthplace data from 1969 population census from Goddard [37].
Mentions: There has emerged a highly resistant form of P. falciparum in the Kabale and Rukungiri districts of southwest Uganda [15] and in bordering areas of Rwanda [16]. The form carries a mutation in the dhfr gene, which confers high level resistance to a number of antifolate drugs in general use (including sulfadoxine-pyrimethamine and chlorproguanil-dapsone). To predict the likely path of dispersal of this resistant form of the parasite, we examined the types and frequency of population movements in Uganda. The region of resistance emergence is shown in red in Figure 2.

View Article: PubMed Central - PubMed

Affiliation: London School of Hygiene and Tropical Medicine, London, UK.

ABSTRACT

Movement of people is the means by which human pathogens are dispersed, so providing health care to mobile sectors of the community is vital to disease control interventions.

Using malaria as a case study, our article examines types of migrant transit and their significance for prevention and treatment of the disease.

Asymptomatic untreated infections act as reservoirs for malaria transmission. Malaria control programmes need to identify those migrant streams with potential to transport malaria and to target prevention and treatment measures appropriately.

Transit has also played a role in the dispersal of antimalarial drug resistance, with the international transportation of artemisinin-resistant parasites by human migration being the greatest threat to the antimalarial treatments used in Africa today.

A geographic framework of human migration at local, national, and international levels is needed so the potential speed and direction of pathogen dispersal can be predicted, and for health policy and services to respond appropriately to the needs of migrants and to threats of pandemic.

Show MeSH
Related in: MedlinePlus