Natural products in caries research: current (limited) knowledge, challenges and future perspective.
Bottom Line: Virulent biofilms firmly attached to tooth surfaces are prime biological factors associated with this disease.Furthermore, most of the studies have been focused on the general inhibitory effects on glucan synthesis as well as on bacterial metabolism and growth, often employing methods that do not address the pathophysiological aspects of the disease (e.g. bacteria in biofilms) and the length of exposure/retention in the mouth.This review focuses on gaps in the current knowledge and presents a model for investigating the use of natural products in anticaries chemotherapy.
Affiliation: Department of Preventive Dentistry, BK 21 Program, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Republic of Korea.Show MeSH
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Mentions: Here, we suggest a research model for initial evaluation (steps 1–3) of natural products in caries research based on our more than 15 years of experience. Steps 4–6 will not be discussed here as these require the highly specialized technical expertise of medicinal chemists, clinical scientists and toxicologists, which may also include industrial partnerships. A comprehensive program ranging from basic laboratory studies to in vivo investigations in animals is offered, which could aid in the development of new chemotherapeutic anticaries approaches for clinical testing. Our suggested strategy is diagramed in figure 2.
Affiliation: Department of Preventive Dentistry, BK 21 Program, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Republic of Korea.