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Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis.

Diniz B, Regatieri C, Andrade R, Maia A - Clin Ophthalmol (2011)

Bottom Line: Perilesional subretinal fluid was observed in two patients.The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. drbrunodiniz@yahoo.com

ABSTRACT

Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) findings and compare them with time domain (TD)-OCT imaging of macula and retinochoroiditis lesions of patients with toxoplasmosis.

Design: Prospective cross-sectional study.

Methods: Ten eyes of 10 patients with active toxoplasmic retinochoroiditis were included. Morphologic features from the macula and retinochoroiditis lesions were obtained at baseline and at 6-week follow up. Scan acquisition protocols for TD-OCT included raster and radial lines through the retinochoroiditis lesion, fast macular, and a linear scan from the lesion to the fovea, whereas the acquisition protocols for SD-OCT also included horizontal volume scans at the lesion site and at the macula. Thickness measurements obtained by SD-OCT were analyzed.

Results: At baseline, macular serous retinal detachment was observed in five patients; two of them only seen by SD-OCT. Retinochoroidal lesions were 4260 μm distant from the fovea on average (R = 681-7130) and this distance had an indirect correlation to the presence of macular detachment. Epiretinal membrane and vitreo-macular traction were also observed. The posterior hyaloid was not identified in four patients by TD-OCT and only in one by SD-OCT at baseline. Perilesional subretinal fluid was observed in two patients. The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.

Conclusion: SD-OCT is a useful tool in the diagnosis of macular changes related with toxoplasmic retinochoroiditis. SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

No MeSH data available.


Related in: MedlinePlus

Baseline fundus photography. Radial scans at baseline (A, B) and after six weeks (C, D). Increased thickness at the perifoveal lesion both by SD-OCT and TD-OCT. Hyper-reflective vitreous dots (asterisk) better seen in A. Decrease of the retinal thickness and disorganization of the layers are seen at follow up. Interruption of the IS/OS junction of the photoreceptor band: arrowhead C, C1.Abbreviations: IS/OS, inner/outer segment; OCT, optical coherence tomography; SD, spectral domain; TD, time domain.
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f4-opth-5-645: Baseline fundus photography. Radial scans at baseline (A, B) and after six weeks (C, D). Increased thickness at the perifoveal lesion both by SD-OCT and TD-OCT. Hyper-reflective vitreous dots (asterisk) better seen in A. Decrease of the retinal thickness and disorganization of the layers are seen at follow up. Interruption of the IS/OS junction of the photoreceptor band: arrowhead C, C1.Abbreviations: IS/OS, inner/outer segment; OCT, optical coherence tomography; SD, spectral domain; TD, time domain.

Mentions: At the 6-week follow up exam, seven patients showed significant decrease of the retinal thickness at the lesion site. The mean retinal thickness decrease was 179 μm from the baseline (P = 0.0004). All patients remained with a disorganization of the retinal layers reflectivity due to scar formation. In two patients, an interruption of the inner/outer segment (IS/OS) junction was noticed temporal to the fovea (Figure 4). ERM was observed near the retinochoroiditis lesion in five patients at the follow-up.


Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis.

Diniz B, Regatieri C, Andrade R, Maia A - Clin Ophthalmol (2011)

Baseline fundus photography. Radial scans at baseline (A, B) and after six weeks (C, D). Increased thickness at the perifoveal lesion both by SD-OCT and TD-OCT. Hyper-reflective vitreous dots (asterisk) better seen in A. Decrease of the retinal thickness and disorganization of the layers are seen at follow up. Interruption of the IS/OS junction of the photoreceptor band: arrowhead C, C1.Abbreviations: IS/OS, inner/outer segment; OCT, optical coherence tomography; SD, spectral domain; TD, time domain.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3104792&req=5

f4-opth-5-645: Baseline fundus photography. Radial scans at baseline (A, B) and after six weeks (C, D). Increased thickness at the perifoveal lesion both by SD-OCT and TD-OCT. Hyper-reflective vitreous dots (asterisk) better seen in A. Decrease of the retinal thickness and disorganization of the layers are seen at follow up. Interruption of the IS/OS junction of the photoreceptor band: arrowhead C, C1.Abbreviations: IS/OS, inner/outer segment; OCT, optical coherence tomography; SD, spectral domain; TD, time domain.
Mentions: At the 6-week follow up exam, seven patients showed significant decrease of the retinal thickness at the lesion site. The mean retinal thickness decrease was 179 μm from the baseline (P = 0.0004). All patients remained with a disorganization of the retinal layers reflectivity due to scar formation. In two patients, an interruption of the inner/outer segment (IS/OS) junction was noticed temporal to the fovea (Figure 4). ERM was observed near the retinochoroiditis lesion in five patients at the follow-up.

Bottom Line: Perilesional subretinal fluid was observed in two patients.The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. drbrunodiniz@yahoo.com

ABSTRACT

Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) findings and compare them with time domain (TD)-OCT imaging of macula and retinochoroiditis lesions of patients with toxoplasmosis.

Design: Prospective cross-sectional study.

Methods: Ten eyes of 10 patients with active toxoplasmic retinochoroiditis were included. Morphologic features from the macula and retinochoroiditis lesions were obtained at baseline and at 6-week follow up. Scan acquisition protocols for TD-OCT included raster and radial lines through the retinochoroiditis lesion, fast macular, and a linear scan from the lesion to the fovea, whereas the acquisition protocols for SD-OCT also included horizontal volume scans at the lesion site and at the macula. Thickness measurements obtained by SD-OCT were analyzed.

Results: At baseline, macular serous retinal detachment was observed in five patients; two of them only seen by SD-OCT. Retinochoroidal lesions were 4260 μm distant from the fovea on average (R = 681-7130) and this distance had an indirect correlation to the presence of macular detachment. Epiretinal membrane and vitreo-macular traction were also observed. The posterior hyaloid was not identified in four patients by TD-OCT and only in one by SD-OCT at baseline. Perilesional subretinal fluid was observed in two patients. The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.

Conclusion: SD-OCT is a useful tool in the diagnosis of macular changes related with toxoplasmic retinochoroiditis. SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

No MeSH data available.


Related in: MedlinePlus