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Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis.

Diniz B, Regatieri C, Andrade R, Maia A - Clin Ophthalmol (2011)

Bottom Line: Perilesional subretinal fluid was observed in two patients.The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. drbrunodiniz@yahoo.com

ABSTRACT

Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) findings and compare them with time domain (TD)-OCT imaging of macula and retinochoroiditis lesions of patients with toxoplasmosis.

Design: Prospective cross-sectional study.

Methods: Ten eyes of 10 patients with active toxoplasmic retinochoroiditis were included. Morphologic features from the macula and retinochoroiditis lesions were obtained at baseline and at 6-week follow up. Scan acquisition protocols for TD-OCT included raster and radial lines through the retinochoroiditis lesion, fast macular, and a linear scan from the lesion to the fovea, whereas the acquisition protocols for SD-OCT also included horizontal volume scans at the lesion site and at the macula. Thickness measurements obtained by SD-OCT were analyzed.

Results: At baseline, macular serous retinal detachment was observed in five patients; two of them only seen by SD-OCT. Retinochoroidal lesions were 4260 μm distant from the fovea on average (R = 681-7130) and this distance had an indirect correlation to the presence of macular detachment. Epiretinal membrane and vitreo-macular traction were also observed. The posterior hyaloid was not identified in four patients by TD-OCT and only in one by SD-OCT at baseline. Perilesional subretinal fluid was observed in two patients. The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.

Conclusion: SD-OCT is a useful tool in the diagnosis of macular changes related with toxoplasmic retinochoroiditis. SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

No MeSH data available.


Related in: MedlinePlus

Baseline fundus photography. Green arrows show the scan acquisition protocol used by spectral domain optical coherence tomography. A, C, and E are from the volume scans at baseline, and G, a linear scan from the fovea to the lesion. B, D, F, and H correspond to the same points at follow up. Vitreoschisis (asterisk) can be noticed at baseline A) and after 6 weeks B). Note the expanded vitreous detachment at follow up. Subretinal fluid at the lesion site (arrowhead) is seen at baseline E) with resolution after 6 weeks F). The triangle shows the retinochoroidal lesion increased thickness at baseline (C, G) and atrophy at follow up (D, H).
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f3-opth-5-645: Baseline fundus photography. Green arrows show the scan acquisition protocol used by spectral domain optical coherence tomography. A, C, and E are from the volume scans at baseline, and G, a linear scan from the fovea to the lesion. B, D, F, and H correspond to the same points at follow up. Vitreoschisis (asterisk) can be noticed at baseline A) and after 6 weeks B). Note the expanded vitreous detachment at follow up. Subretinal fluid at the lesion site (arrowhead) is seen at baseline E) with resolution after 6 weeks F). The triangle shows the retinochoroidal lesion increased thickness at baseline (C, G) and atrophy at follow up (D, H).

Mentions: Retinochoroidal lesions were 4260 ± 705.2 μm from the fovea (range: 681–7130 μm). Increased retinal reflectivity and thickness of the active lesion was found in all patients, using SD-OCT. Subretinal fluid near the lesion was seen in two patients (Figure 3). Retinal pigment epithelial and choriocapillaries band shadowing was noticed by both TD- and SD-OCT due to the inner retinal layers hyper-reflective at the lesion site.


Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis.

Diniz B, Regatieri C, Andrade R, Maia A - Clin Ophthalmol (2011)

Baseline fundus photography. Green arrows show the scan acquisition protocol used by spectral domain optical coherence tomography. A, C, and E are from the volume scans at baseline, and G, a linear scan from the fovea to the lesion. B, D, F, and H correspond to the same points at follow up. Vitreoschisis (asterisk) can be noticed at baseline A) and after 6 weeks B). Note the expanded vitreous detachment at follow up. Subretinal fluid at the lesion site (arrowhead) is seen at baseline E) with resolution after 6 weeks F). The triangle shows the retinochoroidal lesion increased thickness at baseline (C, G) and atrophy at follow up (D, H).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3104792&req=5

f3-opth-5-645: Baseline fundus photography. Green arrows show the scan acquisition protocol used by spectral domain optical coherence tomography. A, C, and E are from the volume scans at baseline, and G, a linear scan from the fovea to the lesion. B, D, F, and H correspond to the same points at follow up. Vitreoschisis (asterisk) can be noticed at baseline A) and after 6 weeks B). Note the expanded vitreous detachment at follow up. Subretinal fluid at the lesion site (arrowhead) is seen at baseline E) with resolution after 6 weeks F). The triangle shows the retinochoroidal lesion increased thickness at baseline (C, G) and atrophy at follow up (D, H).
Mentions: Retinochoroidal lesions were 4260 ± 705.2 μm from the fovea (range: 681–7130 μm). Increased retinal reflectivity and thickness of the active lesion was found in all patients, using SD-OCT. Subretinal fluid near the lesion was seen in two patients (Figure 3). Retinal pigment epithelial and choriocapillaries band shadowing was noticed by both TD- and SD-OCT due to the inner retinal layers hyper-reflective at the lesion site.

Bottom Line: Perilesional subretinal fluid was observed in two patients.The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. drbrunodiniz@yahoo.com

ABSTRACT

Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) findings and compare them with time domain (TD)-OCT imaging of macula and retinochoroiditis lesions of patients with toxoplasmosis.

Design: Prospective cross-sectional study.

Methods: Ten eyes of 10 patients with active toxoplasmic retinochoroiditis were included. Morphologic features from the macula and retinochoroiditis lesions were obtained at baseline and at 6-week follow up. Scan acquisition protocols for TD-OCT included raster and radial lines through the retinochoroiditis lesion, fast macular, and a linear scan from the lesion to the fovea, whereas the acquisition protocols for SD-OCT also included horizontal volume scans at the lesion site and at the macula. Thickness measurements obtained by SD-OCT were analyzed.

Results: At baseline, macular serous retinal detachment was observed in five patients; two of them only seen by SD-OCT. Retinochoroidal lesions were 4260 μm distant from the fovea on average (R = 681-7130) and this distance had an indirect correlation to the presence of macular detachment. Epiretinal membrane and vitreo-macular traction were also observed. The posterior hyaloid was not identified in four patients by TD-OCT and only in one by SD-OCT at baseline. Perilesional subretinal fluid was observed in two patients. The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.

Conclusion: SD-OCT is a useful tool in the diagnosis of macular changes related with toxoplasmic retinochoroiditis. SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

No MeSH data available.


Related in: MedlinePlus