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Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis.

Diniz B, Regatieri C, Andrade R, Maia A - Clin Ophthalmol (2011)

Bottom Line: Perilesional subretinal fluid was observed in two patients.The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. drbrunodiniz@yahoo.com

ABSTRACT

Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) findings and compare them with time domain (TD)-OCT imaging of macula and retinochoroiditis lesions of patients with toxoplasmosis.

Design: Prospective cross-sectional study.

Methods: Ten eyes of 10 patients with active toxoplasmic retinochoroiditis were included. Morphologic features from the macula and retinochoroiditis lesions were obtained at baseline and at 6-week follow up. Scan acquisition protocols for TD-OCT included raster and radial lines through the retinochoroiditis lesion, fast macular, and a linear scan from the lesion to the fovea, whereas the acquisition protocols for SD-OCT also included horizontal volume scans at the lesion site and at the macula. Thickness measurements obtained by SD-OCT were analyzed.

Results: At baseline, macular serous retinal detachment was observed in five patients; two of them only seen by SD-OCT. Retinochoroidal lesions were 4260 μm distant from the fovea on average (R = 681-7130) and this distance had an indirect correlation to the presence of macular detachment. Epiretinal membrane and vitreo-macular traction were also observed. The posterior hyaloid was not identified in four patients by TD-OCT and only in one by SD-OCT at baseline. Perilesional subretinal fluid was observed in two patients. The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.

Conclusion: SD-OCT is a useful tool in the diagnosis of macular changes related with toxoplasmic retinochoroiditis. SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

No MeSH data available.


Related in: MedlinePlus

Fundus photography and radial scans at baseline by SD-OCT A) and TD-OCT C). Increased thickness and disorganization of the retinal layers at the lesion site at A and C (asterisk). Subretinal fluid at the foveal area. Small RPE detachments (arrowhead) only in A. Six-week follow up images by SD-OCT B) and TD-OCT D) show resolution of the subretinal fluid and decrease of the retinal thickness at the lesion site.Abbreviations: OCT, optical coherence tomography; SD, spectral domain; TD, time domain.
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f1-opth-5-645: Fundus photography and radial scans at baseline by SD-OCT A) and TD-OCT C). Increased thickness and disorganization of the retinal layers at the lesion site at A and C (asterisk). Subretinal fluid at the foveal area. Small RPE detachments (arrowhead) only in A. Six-week follow up images by SD-OCT B) and TD-OCT D) show resolution of the subretinal fluid and decrease of the retinal thickness at the lesion site.Abbreviations: OCT, optical coherence tomography; SD, spectral domain; TD, time domain.

Mentions: At baseline, the macular scans of four patients were identified as normal using SD-OCT. Macular serous detachment was observed in five patients. The presence of fluid at baseline had an indirect correlation to the distance of the retinochoroidal lesion to the fovea, but this was not statically significant (P = 0.2831). Retinal pigment epithelium detachment, beneath the subretinal fluid, was present in one patient (Figure 1). ERM was noticed in one patient.


Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis.

Diniz B, Regatieri C, Andrade R, Maia A - Clin Ophthalmol (2011)

Fundus photography and radial scans at baseline by SD-OCT A) and TD-OCT C). Increased thickness and disorganization of the retinal layers at the lesion site at A and C (asterisk). Subretinal fluid at the foveal area. Small RPE detachments (arrowhead) only in A. Six-week follow up images by SD-OCT B) and TD-OCT D) show resolution of the subretinal fluid and decrease of the retinal thickness at the lesion site.Abbreviations: OCT, optical coherence tomography; SD, spectral domain; TD, time domain.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3104792&req=5

f1-opth-5-645: Fundus photography and radial scans at baseline by SD-OCT A) and TD-OCT C). Increased thickness and disorganization of the retinal layers at the lesion site at A and C (asterisk). Subretinal fluid at the foveal area. Small RPE detachments (arrowhead) only in A. Six-week follow up images by SD-OCT B) and TD-OCT D) show resolution of the subretinal fluid and decrease of the retinal thickness at the lesion site.Abbreviations: OCT, optical coherence tomography; SD, spectral domain; TD, time domain.
Mentions: At baseline, the macular scans of four patients were identified as normal using SD-OCT. Macular serous detachment was observed in five patients. The presence of fluid at baseline had an indirect correlation to the distance of the retinochoroidal lesion to the fovea, but this was not statically significant (P = 0.2831). Retinal pigment epithelium detachment, beneath the subretinal fluid, was present in one patient (Figure 1). ERM was noticed in one patient.

Bottom Line: Perilesional subretinal fluid was observed in two patients.The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. drbrunodiniz@yahoo.com

ABSTRACT

Purpose: To investigate spectral domain optical coherence tomography (SD-OCT) findings and compare them with time domain (TD)-OCT imaging of macula and retinochoroiditis lesions of patients with toxoplasmosis.

Design: Prospective cross-sectional study.

Methods: Ten eyes of 10 patients with active toxoplasmic retinochoroiditis were included. Morphologic features from the macula and retinochoroiditis lesions were obtained at baseline and at 6-week follow up. Scan acquisition protocols for TD-OCT included raster and radial lines through the retinochoroiditis lesion, fast macular, and a linear scan from the lesion to the fovea, whereas the acquisition protocols for SD-OCT also included horizontal volume scans at the lesion site and at the macula. Thickness measurements obtained by SD-OCT were analyzed.

Results: At baseline, macular serous retinal detachment was observed in five patients; two of them only seen by SD-OCT. Retinochoroidal lesions were 4260 μm distant from the fovea on average (R = 681-7130) and this distance had an indirect correlation to the presence of macular detachment. Epiretinal membrane and vitreo-macular traction were also observed. The posterior hyaloid was not identified in four patients by TD-OCT and only in one by SD-OCT at baseline. Perilesional subretinal fluid was observed in two patients. The median retinal thickness significantly decreased at the retinochoroiditis lesion (P = 0.0004), and all the patients remained with disorganized retinal layers reflectivity at follow up.

Conclusion: SD-OCT is a useful tool in the diagnosis of macular changes related with toxoplasmic retinochoroiditis. SD-OCT is superior in evaluating retinal changes associated with ocular toxoplasmosis.

No MeSH data available.


Related in: MedlinePlus