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Apocrine fibroadenoma of the perianal region associated with perianal fistula.

Ekci B, Gokce O, Ozkan F - J Clin Med Res (2010)

Bottom Line: In addition, the lesion had both glandular and stromal growth patterns and active chronic inflammation in the background.Malignant or benign counterparts of these types of lesions are widely described in literature.Therefore, it is crucial for the pathologists and clinicians to be aware of such lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Faculty of Medicine, Yeditepe University, Turkey.

ABSTRACT

Unlabelled: A case of a 45 year-old woman who presented with a perianal fistula was reported. Histologically, the excised lesion showed features of apocrine fibroadenoma. In addition, the lesion had both glandular and stromal growth patterns and active chronic inflammation in the background. Malignant or benign counterparts of these types of lesions are widely described in literature. However fistula does not usually accompany and is very rare. Therefore, it is crucial for the pathologists and clinicians to be aware of such lesions. The relationship between apocrine fibroadenoma and perianal region was also discussed.

Keywords: Apocrin fibroadenoma; Perianal region; Fistula.

No MeSH data available.


Related in: MedlinePlus

The glands arranged in a lobular pattern in the fibrotic stroma × 100 H & E.
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Figure 3: The glands arranged in a lobular pattern in the fibrotic stroma × 100 H & E.

Mentions: Grossly, 4 × 2 × 2 cm measuring specimen was composed of a skin piece sized 3 × 1 cm and a firm white fibrous subcutaneous tissue. The orifice of the fistula was observed on the skin and the fistula measured 2 cm in length at the subcutaneous tissue. The cut surface demonstrated bulging, firm, focally fibrotic tissue with cystic spaces. Microscopic tissue sections revealed an architectural pattern similar to the mammary fibroadenoma (Fig. 3). The glands were lined by a double layer of epithelial cells, an outer layer of relatively flat or cuboidal cells, and an inner layer of columnar cells with eosinophilic cytoplasm and focal prominent cytoplasmic snouts protruding into the lumen. Occasionally, glands were arranged in lobuli, resembling those of mammary glands. No nuclear pleomorphism was detected. The stroma appeared to be predominantly fibrotic. In some areas, especially surrounding the glandular ducts, the stroma was relatively loose. The epithelial cells expressed progesterone receptors, but did not express estrogen receptors and were negative for gross cystic disease fluid protein-15 (Fig. 4).


Apocrine fibroadenoma of the perianal region associated with perianal fistula.

Ekci B, Gokce O, Ozkan F - J Clin Med Res (2010)

The glands arranged in a lobular pattern in the fibrotic stroma × 100 H & E.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104665&req=5

Figure 3: The glands arranged in a lobular pattern in the fibrotic stroma × 100 H & E.
Mentions: Grossly, 4 × 2 × 2 cm measuring specimen was composed of a skin piece sized 3 × 1 cm and a firm white fibrous subcutaneous tissue. The orifice of the fistula was observed on the skin and the fistula measured 2 cm in length at the subcutaneous tissue. The cut surface demonstrated bulging, firm, focally fibrotic tissue with cystic spaces. Microscopic tissue sections revealed an architectural pattern similar to the mammary fibroadenoma (Fig. 3). The glands were lined by a double layer of epithelial cells, an outer layer of relatively flat or cuboidal cells, and an inner layer of columnar cells with eosinophilic cytoplasm and focal prominent cytoplasmic snouts protruding into the lumen. Occasionally, glands were arranged in lobuli, resembling those of mammary glands. No nuclear pleomorphism was detected. The stroma appeared to be predominantly fibrotic. In some areas, especially surrounding the glandular ducts, the stroma was relatively loose. The epithelial cells expressed progesterone receptors, but did not express estrogen receptors and were negative for gross cystic disease fluid protein-15 (Fig. 4).

Bottom Line: In addition, the lesion had both glandular and stromal growth patterns and active chronic inflammation in the background.Malignant or benign counterparts of these types of lesions are widely described in literature.Therefore, it is crucial for the pathologists and clinicians to be aware of such lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Faculty of Medicine, Yeditepe University, Turkey.

ABSTRACT

Unlabelled: A case of a 45 year-old woman who presented with a perianal fistula was reported. Histologically, the excised lesion showed features of apocrine fibroadenoma. In addition, the lesion had both glandular and stromal growth patterns and active chronic inflammation in the background. Malignant or benign counterparts of these types of lesions are widely described in literature. However fistula does not usually accompany and is very rare. Therefore, it is crucial for the pathologists and clinicians to be aware of such lesions. The relationship between apocrine fibroadenoma and perianal region was also discussed.

Keywords: Apocrin fibroadenoma; Perianal region; Fistula.

No MeSH data available.


Related in: MedlinePlus