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Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall.

Aneiros-Fernandez J, Arias-Santiago S, Husein-Elahmed H, Ovalle F, Siendones MI, Aneiros-Cachaza J - J Clin Med Res (2010)

Bottom Line: The results of fine needle puncture-aspiration were inconclusive.Subsequent tumorectomy revealed a poorly-defined indurated lesion of 1.1 x 0.7 cm.The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, University Hospital, Granada, Spain.

ABSTRACT

Unlabelled: We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma. Mammography study showed a spiculated lesion in the lower inner quadrant with suspicion of malignancy. The results of fine needle puncture-aspiration were inconclusive. Subsequent tumorectomy revealed a poorly-defined indurated lesion of 1.1 x 0.7 cm. The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors. We present a benign lesion that clinically reproduces a breast carcinoma.

Keywords: Granular cell tumor; Breast; Differential diagnosis; Cutaneous.

No MeSH data available.


Related in: MedlinePlus

Mammography showed an ill-defined, high-density spiculated mass.
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Figure 1: Mammography showed an ill-defined, high-density spiculated mass.

Mentions: Mammography showed an ill-defined, high-density spiculated mass of 1 cm in left inner breast (Fig. 1). No associated calcifications were observed within the mass. Ultrasound revealed a poorly-defined, hypoechoic solid lesion disrupting fascial planes with a strong acoustic shadowing. We classified the mass as category 4c under the Breast Imaging Reporting and Data System (BI-RADS), i.e., with an estimated likelihood of malignancy of 50% - 90%. Results of fine needle aspiration cytology were inconclusive. Radioguided tumorectomy was performed due to clinical suspicion of malignant tumor, evidencing an ill-defined, spiculated, and indurated lesion of 1.1 × 0.7 cm. Histological examination showed an ill-defined firm nodule composed of compact nests and sheets of cells containing eosinophilic cytoplasmic granules with well-defined cell borders and prominent nucleoli (Fig. 2). This lesion was location in dermo-hypodermal junction and subcutaneous fat. The tumor cells were arranged in a fascicular pattern with an infiltrating growth pattern at the margins. The granules were PAS-positive and diastase-resistant in varying degrees of intensity. The immunohistochemical study showed that tumor cells were positive for S100 protein, vimentin, inhibin, and CD68 and were negative for cytokeratin AE1/AE3, smooth muscle actin, desmin, and estrogen and progesterone receptors (Fig. 3). Ki-67 revealed low nuclear proliferative activity. The tumor was completely excised. No evidence of tumor recurrence in left breast has been detected after four-years of follow-up.


Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall.

Aneiros-Fernandez J, Arias-Santiago S, Husein-Elahmed H, Ovalle F, Siendones MI, Aneiros-Cachaza J - J Clin Med Res (2010)

Mammography showed an ill-defined, high-density spiculated mass.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104657&req=5

Figure 1: Mammography showed an ill-defined, high-density spiculated mass.
Mentions: Mammography showed an ill-defined, high-density spiculated mass of 1 cm in left inner breast (Fig. 1). No associated calcifications were observed within the mass. Ultrasound revealed a poorly-defined, hypoechoic solid lesion disrupting fascial planes with a strong acoustic shadowing. We classified the mass as category 4c under the Breast Imaging Reporting and Data System (BI-RADS), i.e., with an estimated likelihood of malignancy of 50% - 90%. Results of fine needle aspiration cytology were inconclusive. Radioguided tumorectomy was performed due to clinical suspicion of malignant tumor, evidencing an ill-defined, spiculated, and indurated lesion of 1.1 × 0.7 cm. Histological examination showed an ill-defined firm nodule composed of compact nests and sheets of cells containing eosinophilic cytoplasmic granules with well-defined cell borders and prominent nucleoli (Fig. 2). This lesion was location in dermo-hypodermal junction and subcutaneous fat. The tumor cells were arranged in a fascicular pattern with an infiltrating growth pattern at the margins. The granules were PAS-positive and diastase-resistant in varying degrees of intensity. The immunohistochemical study showed that tumor cells were positive for S100 protein, vimentin, inhibin, and CD68 and were negative for cytokeratin AE1/AE3, smooth muscle actin, desmin, and estrogen and progesterone receptors (Fig. 3). Ki-67 revealed low nuclear proliferative activity. The tumor was completely excised. No evidence of tumor recurrence in left breast has been detected after four-years of follow-up.

Bottom Line: The results of fine needle puncture-aspiration were inconclusive.Subsequent tumorectomy revealed a poorly-defined indurated lesion of 1.1 x 0.7 cm.The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, University Hospital, Granada, Spain.

ABSTRACT

Unlabelled: We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma. Mammography study showed a spiculated lesion in the lower inner quadrant with suspicion of malignancy. The results of fine needle puncture-aspiration were inconclusive. Subsequent tumorectomy revealed a poorly-defined indurated lesion of 1.1 x 0.7 cm. The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors. We present a benign lesion that clinically reproduces a breast carcinoma.

Keywords: Granular cell tumor; Breast; Differential diagnosis; Cutaneous.

No MeSH data available.


Related in: MedlinePlus