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Wilms tumor in a 37-year-old.

Thevendran G, Farne HA, Kaisary AV - J Clin Med Res (2010)

Bottom Line: A radical nephrectomy was performed and the patient was due for chemotherapy.Recent advances, controversies and current recommendations in the treatment of AWT are discussed.Adult; Wilms tumor; Kidney.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, St. Marys Hospital, London, UK.

ABSTRACT

Unlabelled: Wilms tumor is rare in adults. Though the approach to diagnosis and treatment of adult Wilms tumor (AWT) is closely modeled on recommendations for childhood Wilms tumor, views differ on how aggressive the treatment should be. We report a case of a 37-year-old with Stage III favorable histology AWT. A radical nephrectomy was performed and the patient was due for chemotherapy. Recent advances, controversies and current recommendations in the treatment of AWT are discussed.

Keywords: Adult; Wilms tumor; Kidney.

No MeSH data available.


Related in: MedlinePlus

WT-1 staining showing strong nuclear positivity in the glandular component and weak nuclear positivity in the stromal component
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Figure 5: WT-1 staining showing strong nuclear positivity in the glandular component and weak nuclear positivity in the stromal component

Mentions: In view of the high index of suspicion of malignancy, a left radical nephrectomy was performed. At surgery, a large mass was seen arising from the upper pole of the left kidney. Left para aortic lympadenopathy extending down to the left common iliac artery was noted. Subsequent histological examination of the nephrectomy specimen was reported as a large lobulated cream colored tumor composed of solid, necrotic and hemorrhagic areas. The tumor measured 95 × 95 × 142 mm and was situated in the upper pole and mid zone of the kidney. Microscopy revealed a triphasic tumor composed of epithelial, blastematous and stromal elements (Fig. 4, 5). There was extracapsular spread with up to five hilar lymph nodes involved. The diagnosis was a Stage III favorable histology Wilms’ tumor with clear resection margins.


Wilms tumor in a 37-year-old.

Thevendran G, Farne HA, Kaisary AV - J Clin Med Res (2010)

WT-1 staining showing strong nuclear positivity in the glandular component and weak nuclear positivity in the stromal component
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104656&req=5

Figure 5: WT-1 staining showing strong nuclear positivity in the glandular component and weak nuclear positivity in the stromal component
Mentions: In view of the high index of suspicion of malignancy, a left radical nephrectomy was performed. At surgery, a large mass was seen arising from the upper pole of the left kidney. Left para aortic lympadenopathy extending down to the left common iliac artery was noted. Subsequent histological examination of the nephrectomy specimen was reported as a large lobulated cream colored tumor composed of solid, necrotic and hemorrhagic areas. The tumor measured 95 × 95 × 142 mm and was situated in the upper pole and mid zone of the kidney. Microscopy revealed a triphasic tumor composed of epithelial, blastematous and stromal elements (Fig. 4, 5). There was extracapsular spread with up to five hilar lymph nodes involved. The diagnosis was a Stage III favorable histology Wilms’ tumor with clear resection margins.

Bottom Line: A radical nephrectomy was performed and the patient was due for chemotherapy.Recent advances, controversies and current recommendations in the treatment of AWT are discussed.Adult; Wilms tumor; Kidney.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, St. Marys Hospital, London, UK.

ABSTRACT

Unlabelled: Wilms tumor is rare in adults. Though the approach to diagnosis and treatment of adult Wilms tumor (AWT) is closely modeled on recommendations for childhood Wilms tumor, views differ on how aggressive the treatment should be. We report a case of a 37-year-old with Stage III favorable histology AWT. A radical nephrectomy was performed and the patient was due for chemotherapy. Recent advances, controversies and current recommendations in the treatment of AWT are discussed.

Keywords: Adult; Wilms tumor; Kidney.

No MeSH data available.


Related in: MedlinePlus