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The role of stem cells in tumor targeting and growth suppression of gliomas.

Eskandary H, Basiri M, Nematollahi-Mahani SN, Mehravaran S - Biologics (2011)

Bottom Line: Glioma remains the most challenging solid organ tumor to treat successfully.In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo.This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Research Center.

ABSTRACT
Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.

No MeSH data available.


Related in: MedlinePlus

Some suggested mechanisms of tumor growth suppression of unmodified stem cells.
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f2-btt-5-061: Some suggested mechanisms of tumor growth suppression of unmodified stem cells.

Mentions: While the mechanisms by which modified stem cells suppress tumor growth are more often studied (see Achanta et al14), the precise mechanisms by which unmodified stem cells suppress tumor growth are not completely understood. We suppose that biochemical immunological and physical effects are responsible for growth inhibition of glioma tumor. A few mechanisms are suggested in some reports, including the following (Figure 2):


The role of stem cells in tumor targeting and growth suppression of gliomas.

Eskandary H, Basiri M, Nematollahi-Mahani SN, Mehravaran S - Biologics (2011)

Some suggested mechanisms of tumor growth suppression of unmodified stem cells.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3104605&req=5

f2-btt-5-061: Some suggested mechanisms of tumor growth suppression of unmodified stem cells.
Mentions: While the mechanisms by which modified stem cells suppress tumor growth are more often studied (see Achanta et al14), the precise mechanisms by which unmodified stem cells suppress tumor growth are not completely understood. We suppose that biochemical immunological and physical effects are responsible for growth inhibition of glioma tumor. A few mechanisms are suggested in some reports, including the following (Figure 2):

Bottom Line: Glioma remains the most challenging solid organ tumor to treat successfully.In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo.This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Research Center.

ABSTRACT
Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.

No MeSH data available.


Related in: MedlinePlus