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The role of stem cells in tumor targeting and growth suppression of gliomas.

Eskandary H, Basiri M, Nematollahi-Mahani SN, Mehravaran S - Biologics (2011)

Bottom Line: Glioma remains the most challenging solid organ tumor to treat successfully.In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo.This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Research Center.

ABSTRACT
Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.

No MeSH data available.


Related in: MedlinePlus

Stem cell migration is related to two groups of inducing factors of chemo-attractant cytokines and extracellular matrix.
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f1-btt-5-061: Stem cell migration is related to two groups of inducing factors of chemo-attractant cytokines and extracellular matrix.

Mentions: In this review, we concentrated on stem cell migration toward glioma tumors and provided some suggested mechanisms by which these stem cells may suppress tumor growth. Brain lesions, tumors, and neurological diseases trigger migration of neural stem cell/progenitor cells toward these altered structures. An understanding of the factors involved in to such cell migration events is a necessary step in delineating the critical pathways that control NSC tropism. The factors that are involved in migration of NSCs can be divided into two main groups: chemoattractant cytokines, including HGF, EGF, VEGF, TGF, FGF, PDGF, MPC-1, IL-8, IL-4, and SDF-1a15,35–37,41,43,49,50,72 and extracellular matrix compounds, such as tenascin, fibronectin, laminin, vitronectin, various types of collagen, and hyaluronic acid (Figure 1).2,44–47,73,74


The role of stem cells in tumor targeting and growth suppression of gliomas.

Eskandary H, Basiri M, Nematollahi-Mahani SN, Mehravaran S - Biologics (2011)

Stem cell migration is related to two groups of inducing factors of chemo-attractant cytokines and extracellular matrix.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3104605&req=5

f1-btt-5-061: Stem cell migration is related to two groups of inducing factors of chemo-attractant cytokines and extracellular matrix.
Mentions: In this review, we concentrated on stem cell migration toward glioma tumors and provided some suggested mechanisms by which these stem cells may suppress tumor growth. Brain lesions, tumors, and neurological diseases trigger migration of neural stem cell/progenitor cells toward these altered structures. An understanding of the factors involved in to such cell migration events is a necessary step in delineating the critical pathways that control NSC tropism. The factors that are involved in migration of NSCs can be divided into two main groups: chemoattractant cytokines, including HGF, EGF, VEGF, TGF, FGF, PDGF, MPC-1, IL-8, IL-4, and SDF-1a15,35–37,41,43,49,50,72 and extracellular matrix compounds, such as tenascin, fibronectin, laminin, vitronectin, various types of collagen, and hyaluronic acid (Figure 1).2,44–47,73,74

Bottom Line: Glioma remains the most challenging solid organ tumor to treat successfully.In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo.This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Research Center.

ABSTRACT
Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.

No MeSH data available.


Related in: MedlinePlus