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Effects of red grape juice consumption on high density lipoprotein-cholesterol, apolipoprotein AI, apolipoprotein B and homocysteine in healthy human volunteers.

Khadem-Ansari MH, Rasmi Y, Ramezani F - Open Biochem J (2010)

Bottom Line: It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease.But apoAI levels were not changed significantly before and after of RGj consumption (154.27 ± 21.55 and 155.35 ± 21.07 mg/dl; P>0.05).Hcy levels were decreased after RGj consumption (7.70 ± 2.80 and 6.20 ± 2.30 µmol/l; P<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry and Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT
It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease. We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-cholesterol (HDL-C), apolipoprotein AI (apoAI), apolipoprotein B (apoB) and homocysteine (Hcy) levels in healthy human volunteers. Twenty six healthy and nonsmoking males, aged between 25-60 years, who were under no medication asked to consume 150 ml of RGj twice per day for one month. Serum HDL-C, apoAI, apoB and plasma Hcy levels were measured before and after one month RGj consumption. HDL-C levels after RGj consumption were significantly higher than the corresponding levels before the RGj consumption (41.44 ± 4.50 and 44.37 ± 4.30 mg/dl; P<0.0001). Also, apoB was significantly increased after RGj consumption (149.0 ± 22.35 and 157.19 ± 18.60 mg/dl; P<0.002). But apoAI levels were not changed significantly before and after of RGj consumption (154.27 ± 21.55 and 155.35 ± 21.07 mg/dl; P>0.05). Hcy levels were decreased after RGj consumption (7.70 ± 2.80 and 6.20 ± 2.30 µmol/l; P<0.001). The present study demonstrates that RGj consumption can significantly increase serum HDL-C levels and decrease Hcy levels. These findings may have important implications for the prevention of atherosclerosis in healthy individuals.

No MeSH data available.


Related in: MedlinePlus

Homocysteine concentration before and after red grape juice consumption (p<0.001).
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Figure 4: Homocysteine concentration before and after red grape juice consumption (p<0.001).

Mentions: Figures show the serum HDL-C, apo AI, apo B and plasma Hcy levels before and after one month RGj consumption. HDL-C values were 41.44 ± 4.50 mg/dl and 44.37 ± 4.30 mg/dl before and after RGj consumption, respectively (p<0.0001; Fig. 1). Serum apo B levels measured 149.0 ± 22.35 mg/dl and 157.19 ± 18.60 mg/dl before and after RGj consumption, respectively (p<0.002; Fig. 2). Serum apo AI measured 154.27 ± 21.55 mg/dl and 155.35 ± 21.07 mg/dl before and after RGj consumption, respectively, which show that it was not changed significantly (p>0.05; Fig. 3). Plasma Hcy levels were 7.70 ± 2.80 µmol/l and 6.20 ± 2.30 µmol/l before and after RGj consumption, respectively, thus indicating a significantly decrease (p<0.001; Fig. 4).


Effects of red grape juice consumption on high density lipoprotein-cholesterol, apolipoprotein AI, apolipoprotein B and homocysteine in healthy human volunteers.

Khadem-Ansari MH, Rasmi Y, Ramezani F - Open Biochem J (2010)

Homocysteine concentration before and after red grape juice consumption (p<0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104594&req=5

Figure 4: Homocysteine concentration before and after red grape juice consumption (p<0.001).
Mentions: Figures show the serum HDL-C, apo AI, apo B and plasma Hcy levels before and after one month RGj consumption. HDL-C values were 41.44 ± 4.50 mg/dl and 44.37 ± 4.30 mg/dl before and after RGj consumption, respectively (p<0.0001; Fig. 1). Serum apo B levels measured 149.0 ± 22.35 mg/dl and 157.19 ± 18.60 mg/dl before and after RGj consumption, respectively (p<0.002; Fig. 2). Serum apo AI measured 154.27 ± 21.55 mg/dl and 155.35 ± 21.07 mg/dl before and after RGj consumption, respectively, which show that it was not changed significantly (p>0.05; Fig. 3). Plasma Hcy levels were 7.70 ± 2.80 µmol/l and 6.20 ± 2.30 µmol/l before and after RGj consumption, respectively, thus indicating a significantly decrease (p<0.001; Fig. 4).

Bottom Line: It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease.But apoAI levels were not changed significantly before and after of RGj consumption (154.27 ± 21.55 and 155.35 ± 21.07 mg/dl; P>0.05).Hcy levels were decreased after RGj consumption (7.70 ± 2.80 and 6.20 ± 2.30 µmol/l; P<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry and Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT
It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease. We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-cholesterol (HDL-C), apolipoprotein AI (apoAI), apolipoprotein B (apoB) and homocysteine (Hcy) levels in healthy human volunteers. Twenty six healthy and nonsmoking males, aged between 25-60 years, who were under no medication asked to consume 150 ml of RGj twice per day for one month. Serum HDL-C, apoAI, apoB and plasma Hcy levels were measured before and after one month RGj consumption. HDL-C levels after RGj consumption were significantly higher than the corresponding levels before the RGj consumption (41.44 ± 4.50 and 44.37 ± 4.30 mg/dl; P<0.0001). Also, apoB was significantly increased after RGj consumption (149.0 ± 22.35 and 157.19 ± 18.60 mg/dl; P<0.002). But apoAI levels were not changed significantly before and after of RGj consumption (154.27 ± 21.55 and 155.35 ± 21.07 mg/dl; P>0.05). Hcy levels were decreased after RGj consumption (7.70 ± 2.80 and 6.20 ± 2.30 µmol/l; P<0.001). The present study demonstrates that RGj consumption can significantly increase serum HDL-C levels and decrease Hcy levels. These findings may have important implications for the prevention of atherosclerosis in healthy individuals.

No MeSH data available.


Related in: MedlinePlus