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Expression of vascular endothelial growth factor on chondrocytes increases with osteoarthritis - an animal experimental investigation.

Tibesku CO, Daniilidis K, Skwara A, Paletta J, Szuwart T, Fuchs-Winkelmann S - Open Orthop J (2011)

Bottom Line: There was no difference in the progression of OA between control and experimental groups after 3 weeks, but a significant difference was seen after 6 (p=0,01) and 12 (p=0,05) weeks.A significant positive correlation between VEGF expression and the histological grade of OA was found (r = 0.767; p<0.01).An increase of VEGF expressing chondrocytes occurs during time course of OA.

View Article: PubMed Central - PubMed

Affiliation: Sporthopaedicum Straubing, Germany.

ABSTRACT

Objective: To evaluate the expression of VEGF by chondrocytes of hyaline cartilage during the course of osteoarthritis (OA).

Methods: In 12 white New Zealand rabbits the anterior cruciate ligament (ACL) was resected to create an anterior instability of the knee. In 12 control rabbits only a sham operation without resection of the ACL was done. Four animals of each group were killed at 3, 6, and 12 weeks. The load bearing area was evaluated histologically according to Mankin and by immunostaining for VEGF.

Results: In the experimental group, histological grades of OA showed a positive linear correlation with the time after surgery. Immunostaining showed an increased expression of VEGF in the control group after 3 weeks, which dropped to normal after 6 weeks. There was no difference in the progression of OA between control and experimental groups after 3 weeks, but a significant difference was seen after 6 (p=0,01) and 12 (p=0,05) weeks. A significant positive correlation between VEGF expression and the histological grade of OA was found (r = 0.767; p<0.01).

Conclusions: An increase of VEGF expressing chondrocytes occurs during time course of OA.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical staining of VEGF, 6 weeks after sham operation (left side) and 6 weeks after resection of the anterior cruciate ligament (right side).
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Figure 4: Immunohistochemical staining of VEGF, 6 weeks after sham operation (left side) and 6 weeks after resection of the anterior cruciate ligament (right side).


Expression of vascular endothelial growth factor on chondrocytes increases with osteoarthritis - an animal experimental investigation.

Tibesku CO, Daniilidis K, Skwara A, Paletta J, Szuwart T, Fuchs-Winkelmann S - Open Orthop J (2011)

Immunohistochemical staining of VEGF, 6 weeks after sham operation (left side) and 6 weeks after resection of the anterior cruciate ligament (right side).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104593&req=5

Figure 4: Immunohistochemical staining of VEGF, 6 weeks after sham operation (left side) and 6 weeks after resection of the anterior cruciate ligament (right side).
Bottom Line: There was no difference in the progression of OA between control and experimental groups after 3 weeks, but a significant difference was seen after 6 (p=0,01) and 12 (p=0,05) weeks.A significant positive correlation between VEGF expression and the histological grade of OA was found (r = 0.767; p<0.01).An increase of VEGF expressing chondrocytes occurs during time course of OA.

View Article: PubMed Central - PubMed

Affiliation: Sporthopaedicum Straubing, Germany.

ABSTRACT

Objective: To evaluate the expression of VEGF by chondrocytes of hyaline cartilage during the course of osteoarthritis (OA).

Methods: In 12 white New Zealand rabbits the anterior cruciate ligament (ACL) was resected to create an anterior instability of the knee. In 12 control rabbits only a sham operation without resection of the ACL was done. Four animals of each group were killed at 3, 6, and 12 weeks. The load bearing area was evaluated histologically according to Mankin and by immunostaining for VEGF.

Results: In the experimental group, histological grades of OA showed a positive linear correlation with the time after surgery. Immunostaining showed an increased expression of VEGF in the control group after 3 weeks, which dropped to normal after 6 weeks. There was no difference in the progression of OA between control and experimental groups after 3 weeks, but a significant difference was seen after 6 (p=0,01) and 12 (p=0,05) weeks. A significant positive correlation between VEGF expression and the histological grade of OA was found (r = 0.767; p<0.01).

Conclusions: An increase of VEGF expressing chondrocytes occurs during time course of OA.

No MeSH data available.


Related in: MedlinePlus