The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Bottom Line: Regulatory T cells (Tregs) have a central role in maintaining immune homoeostasis through various mechanisms.Nr4a2 binds to regulatory regions of Foxp3, where it mediates permissive histone modifications.Nr4a2-deficeint Tregs are prone to lose Foxp3 expression and have attenuated suppressive ability both in vitro and in vivo.
Affiliation: Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.Show MeSH
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Mentions: We confirmed that the expression levels of Nr4a2 were higher in Foxp3+ Tregs than in Foxp3− T cells at both the protein and mRNA levels (Fig. 1a). Nr4a2 was low in naïve T cells, but was transiently induced by TCR stimulation (Fig. 1b). Nr4a2 was undetectable in Th1, Th2, Th17 or iTreg cells differentiated in vitro (Supplementary Fig. S2).
Affiliation: Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.