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The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes.

Lee W - Diagn Pathol (2011)

Bottom Line: The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p < 0.05).The incidence of a decreased CEACAM1 expression was not different between the diabetic and non-diabetic groups.This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Dankook University College of Medicine, Cheonan, Korea. walee@dankook.ac.kr

ABSTRACT

Background: Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an important candidate for causing insulin resistance.

Methods: The CEACAM1 expression was evaluated immunohistochemically in the liver tissues of 99 severely obese or non-obese subjects with or without diabetes. The CEACAM1 expression was classified into two categories: a normal expression or a decreased expression.

Results: The CEACAM1 expression was markedly decreased in the hepatocytes with macrovesicular steatosis. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p < 0.05). The incidence of a decreased CEACAM1 expression was not different between the diabetic and non-diabetic groups.

Conclusions: This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.

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The liver tissue is associated with severe fatty change (A) and it shows a distinct loss of CEACAM1 expression immunohistochemically (B).
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Figure 2: The liver tissue is associated with severe fatty change (A) and it shows a distinct loss of CEACAM1 expression immunohistochemically (B).

Mentions: CEACAM1 protein was strongly expressed alongside the cannalicular membrane of hepatocytes (Figure 1). The CEACAM1 expression was lost mainly in the hepatocytes with fatty change, particularly macrovesicular steatosis (Figure 2). The relationship of a CEACAM1 expression with diabetes, severe obesity, high grade fatty liver and NASH was summarized in Table 2. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. A decreased CEACAM-1 expression was associated with high grade fatty change compared to absent or low grade fatty change (p < 0.05). A decreased CEACAM1 expression was also associated with severe obesity with or without diabetes rather than being associated with non-obesity with or without diabetes (p < 0.05). The incidence of a decreased CEACAM1 expression was significantly higher in severely obese patients with NASH than severely obese patients without NASH (p < 0.05). The incidence of CEACAM1 expression was not different between the diabetic and non-diabetic groups. A decreased CEACAM1 expression was noted in following descending order, severely obese diabetics, severely obese non-diabetics, non-obese diabetics and non-obese non-diabetics (p < 0.05) (Table 3). The relationship of high grade fatty liver, NASH and CEACAM1 expression with severely obese patients that were grouped into diabetics, non-diabetics with abnormal glucose test and non-diabetics with normal glucose test, was summarized in Table 4. There were no statistically significant differences in high grade fatty liver, NASH and a decreased CEACAM1 expression between 3 groups of severely obese patients.


The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes.

Lee W - Diagn Pathol (2011)

The liver tissue is associated with severe fatty change (A) and it shows a distinct loss of CEACAM1 expression immunohistochemically (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104481&req=5

Figure 2: The liver tissue is associated with severe fatty change (A) and it shows a distinct loss of CEACAM1 expression immunohistochemically (B).
Mentions: CEACAM1 protein was strongly expressed alongside the cannalicular membrane of hepatocytes (Figure 1). The CEACAM1 expression was lost mainly in the hepatocytes with fatty change, particularly macrovesicular steatosis (Figure 2). The relationship of a CEACAM1 expression with diabetes, severe obesity, high grade fatty liver and NASH was summarized in Table 2. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. A decreased CEACAM-1 expression was associated with high grade fatty change compared to absent or low grade fatty change (p < 0.05). A decreased CEACAM1 expression was also associated with severe obesity with or without diabetes rather than being associated with non-obesity with or without diabetes (p < 0.05). The incidence of a decreased CEACAM1 expression was significantly higher in severely obese patients with NASH than severely obese patients without NASH (p < 0.05). The incidence of CEACAM1 expression was not different between the diabetic and non-diabetic groups. A decreased CEACAM1 expression was noted in following descending order, severely obese diabetics, severely obese non-diabetics, non-obese diabetics and non-obese non-diabetics (p < 0.05) (Table 3). The relationship of high grade fatty liver, NASH and CEACAM1 expression with severely obese patients that were grouped into diabetics, non-diabetics with abnormal glucose test and non-diabetics with normal glucose test, was summarized in Table 4. There were no statistically significant differences in high grade fatty liver, NASH and a decreased CEACAM1 expression between 3 groups of severely obese patients.

Bottom Line: The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p < 0.05).The incidence of a decreased CEACAM1 expression was not different between the diabetic and non-diabetic groups.This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Dankook University College of Medicine, Cheonan, Korea. walee@dankook.ac.kr

ABSTRACT

Background: Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an important candidate for causing insulin resistance.

Methods: The CEACAM1 expression was evaluated immunohistochemically in the liver tissues of 99 severely obese or non-obese subjects with or without diabetes. The CEACAM1 expression was classified into two categories: a normal expression or a decreased expression.

Results: The CEACAM1 expression was markedly decreased in the hepatocytes with macrovesicular steatosis. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p < 0.05). The incidence of a decreased CEACAM1 expression was not different between the diabetic and non-diabetic groups.

Conclusions: This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.

Show MeSH
Related in: MedlinePlus