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Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma.

Rousseau MC, Boulay ME, Goronfolah L, Denburg J, Keith P, Boulet LP - Allergy Asthma Clin Immunol (2011)

Bottom Line: Subjects underwent a control challenge (normal saline) followed by 4 consecutive daily NAC.Compared with the control day, there was a significant increase in symptom scores and NBI 10 minutes after each last daily NAC in both groups (p < 0.05).No cumulative effect or any late response were observed in any of the groups over the challenge period.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre de recherche, Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada. lpboulet@med.ulaval.ca.

ABSTRACT

Background: Nasal allergen challenge (NAC) is useful to study the pathophysiology of rhinitis, and multiple challenges may more adequately approximate natural exposure.

Objective: To determine the effect of 4 consecutive daily NAC, on clinical and inflammatory parameters in rhinitics with or without asthma.

Methods: Rhinitic subjects were recruited: 19 with mild asthma and 13 without asthma. Subjects underwent a control challenge (normal saline) followed by 4 consecutive daily NAC. Allergen challenge consisted of spraying the chosen allergen extract into each nostril until a positive nasal response occurred. Symptoms were recorded on a Likert scale, and oral peak expiratory and nasal peak inspiratory flows allowed assessment of a nasal blockage index (NBI), for a period of 7 hours. Induced sputum and nasal lavage were performed on control day and after 1 and 4 days of NAC.

Results: Compared with the control day, there was a significant increase in symptom scores and NBI 10 minutes after each last daily NAC in both groups (p < 0.05). Symptom scores and NBI were similar for the 2 groups, except for nasal obstruction and rhinorrhea, which were more marked in subjects with asthma and rhinitis, respectively. Nasal lavage eosinophils were increased after 4 days of challenges in both groups, but there was no change in sputum eosinophils. No cumulative effect or any late response were observed in any of the groups over the challenge period.

Conclusion: Multiple NAC may be a useful tool to study the pathophysiology of allergic rhinitis or its relationships with asthma.

Trial registration: ClinicalTrials.gov NCT01286129.

No MeSH data available.


Related in: MedlinePlus

Effect of nasal challenge with saline (control day) or allergen (days 1-4) on NBI. (a) for rhinitics and (b) for asthmatics at 0 min and over 7 hours post-challenge. *p < 0.05; 0 min vs 10 min on days 1-4. **p < 0.05; Control day vs days 1-4.
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Figure 2: Effect of nasal challenge with saline (control day) or allergen (days 1-4) on NBI. (a) for rhinitics and (b) for asthmatics at 0 min and over 7 hours post-challenge. *p < 0.05; 0 min vs 10 min on days 1-4. **p < 0.05; Control day vs days 1-4.

Mentions: Over the 4 challenge days, no differences in baseline NBI values were detected between and within subjects, irrespective of their group (Figure 2). On control day, no significant change in NBI was observed over time and the response was similar between groups. Ten minutes after obtaining a positive response on each allergen challenge day, an increased NBI value was observed for the two groups compared with baseline value (p < 0.05) and the response was similar for the 2 groups. Moreover, the comparison of each allergen challenge day with control day showed a significant increase in NBI from 10 min to 1.5h post-challenge.


Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma.

Rousseau MC, Boulay ME, Goronfolah L, Denburg J, Keith P, Boulet LP - Allergy Asthma Clin Immunol (2011)

Effect of nasal challenge with saline (control day) or allergen (days 1-4) on NBI. (a) for rhinitics and (b) for asthmatics at 0 min and over 7 hours post-challenge. *p < 0.05; 0 min vs 10 min on days 1-4. **p < 0.05; Control day vs days 1-4.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104480&req=5

Figure 2: Effect of nasal challenge with saline (control day) or allergen (days 1-4) on NBI. (a) for rhinitics and (b) for asthmatics at 0 min and over 7 hours post-challenge. *p < 0.05; 0 min vs 10 min on days 1-4. **p < 0.05; Control day vs days 1-4.
Mentions: Over the 4 challenge days, no differences in baseline NBI values were detected between and within subjects, irrespective of their group (Figure 2). On control day, no significant change in NBI was observed over time and the response was similar between groups. Ten minutes after obtaining a positive response on each allergen challenge day, an increased NBI value was observed for the two groups compared with baseline value (p < 0.05) and the response was similar for the 2 groups. Moreover, the comparison of each allergen challenge day with control day showed a significant increase in NBI from 10 min to 1.5h post-challenge.

Bottom Line: Subjects underwent a control challenge (normal saline) followed by 4 consecutive daily NAC.Compared with the control day, there was a significant increase in symptom scores and NBI 10 minutes after each last daily NAC in both groups (p < 0.05).No cumulative effect or any late response were observed in any of the groups over the challenge period.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre de recherche, Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada. lpboulet@med.ulaval.ca.

ABSTRACT

Background: Nasal allergen challenge (NAC) is useful to study the pathophysiology of rhinitis, and multiple challenges may more adequately approximate natural exposure.

Objective: To determine the effect of 4 consecutive daily NAC, on clinical and inflammatory parameters in rhinitics with or without asthma.

Methods: Rhinitic subjects were recruited: 19 with mild asthma and 13 without asthma. Subjects underwent a control challenge (normal saline) followed by 4 consecutive daily NAC. Allergen challenge consisted of spraying the chosen allergen extract into each nostril until a positive nasal response occurred. Symptoms were recorded on a Likert scale, and oral peak expiratory and nasal peak inspiratory flows allowed assessment of a nasal blockage index (NBI), for a period of 7 hours. Induced sputum and nasal lavage were performed on control day and after 1 and 4 days of NAC.

Results: Compared with the control day, there was a significant increase in symptom scores and NBI 10 minutes after each last daily NAC in both groups (p < 0.05). Symptom scores and NBI were similar for the 2 groups, except for nasal obstruction and rhinorrhea, which were more marked in subjects with asthma and rhinitis, respectively. Nasal lavage eosinophils were increased after 4 days of challenges in both groups, but there was no change in sputum eosinophils. No cumulative effect or any late response were observed in any of the groups over the challenge period.

Conclusion: Multiple NAC may be a useful tool to study the pathophysiology of allergic rhinitis or its relationships with asthma.

Trial registration: ClinicalTrials.gov NCT01286129.

No MeSH data available.


Related in: MedlinePlus