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Inflammatory and tumor stimulating responses after laparoscopic sigmoidectomy.

Kim JS, Hur H, Min BS, Lee KY, Chung HC, Kim NK - Yonsei Med. J. (2011)

Bottom Line: However, objective evidence of its immunologic and oncologic benefits is scarce.Clinical parameters and serum markers were compared.However, there were no significant differences in the preoperative and postoperative levels of CRP, IL-6, VEGF, and IGFBP-3 between the two groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu, Seoul 120-752, Korea.

ABSTRACT

Purpose: Laparoscopic colectomy has clinical benefits such as short hospital stay, less postoperative pain, and early return of bowel function. However, objective evidence of its immunologic and oncologic benefits is scarce. We compared functional recovery after open versus laparoscopic sigmoidectomy and investigated the effect of open versus laparoscopic surgery on acute inflammation as well as tumor stimulation.

Materials and methods: A total of 57 patients who were diagnosed with sigmoid colon cancer were randomized for elective conventional or laparoscopically assisted sigmoidectomy. Serum samples were obtained preoperatively and on postoperative day 1. C-reactive protein (CRP) and interleukin-6 (IL-6) were measured as inflammation markers, and vascular endothelial growth factor (VEGF) and insulin-like growth factor binding protein-3 (IGFBP-3) were used as tumor stimulation factors. Clinical parameters and serum markers were compared.

Results: Postoperative hospital stay (p=0.031), the first day of gas out (p=0.016), and the first day of soft diet (p<0.001) were significantly shorter for the laparoscopic surgery group than the open surgery group. The levels of CRP, IL-6, and VEGF rose significantly, and the concentration of IGFBP-3 fell significantly after both open and laparoscopic surgery. However, there were no significant differences in the preoperative and postoperative levels of CRP, IL-6, VEGF, and IGFBP-3 between the two groups.

Conclusion: Our data suggest that both open and laparoscopic surgeries are accompanied by significant changes in IL-6, CRP, IGFBP-3, and VEGF levels. Acute inflammation markers and tumor stimulating factors may not reflect clinical benefits of laparoscopic surgery.

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Related in: MedlinePlus

Changes in the serum concentration of vascular endothelial growth factor (VEGF) in patients undergoing open or laparoscopic surgery for sigmoid colon cancer. No significant differences were found between the open and laparoscopic surgery groups. *p<0.001 Preoperative (Preop) value versus the first postoperative day (POD1).
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Figure 4: Changes in the serum concentration of vascular endothelial growth factor (VEGF) in patients undergoing open or laparoscopic surgery for sigmoid colon cancer. No significant differences were found between the open and laparoscopic surgery groups. *p<0.001 Preoperative (Preop) value versus the first postoperative day (POD1).

Mentions: No differences in serum concentrations of preoperative and postoperative CRP, IL-6, IGFBP-3, and VEGF were observed between the two groups (Table 2). However, CRP, IL-6, and VEGF levels rose significantly after both open and laparoscopic surgeries (p<0.001 in each group) (Figs. 2, 3 and 4). In contrast, the concentration of IGFBP-3 decreased significantly after open and laparoscopic surgeries (p=0.03 in the open surgery group and p=0.003 for the laparoscopic surgery group) (Fig. 5). However, there were no significant differences in CRP, IL-6, VEGF, and IGFBP-3 levels between the open and laparoscopic surgery groups.


Inflammatory and tumor stimulating responses after laparoscopic sigmoidectomy.

Kim JS, Hur H, Min BS, Lee KY, Chung HC, Kim NK - Yonsei Med. J. (2011)

Changes in the serum concentration of vascular endothelial growth factor (VEGF) in patients undergoing open or laparoscopic surgery for sigmoid colon cancer. No significant differences were found between the open and laparoscopic surgery groups. *p<0.001 Preoperative (Preop) value versus the first postoperative day (POD1).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104449&req=5

Figure 4: Changes in the serum concentration of vascular endothelial growth factor (VEGF) in patients undergoing open or laparoscopic surgery for sigmoid colon cancer. No significant differences were found between the open and laparoscopic surgery groups. *p<0.001 Preoperative (Preop) value versus the first postoperative day (POD1).
Mentions: No differences in serum concentrations of preoperative and postoperative CRP, IL-6, IGFBP-3, and VEGF were observed between the two groups (Table 2). However, CRP, IL-6, and VEGF levels rose significantly after both open and laparoscopic surgeries (p<0.001 in each group) (Figs. 2, 3 and 4). In contrast, the concentration of IGFBP-3 decreased significantly after open and laparoscopic surgeries (p=0.03 in the open surgery group and p=0.003 for the laparoscopic surgery group) (Fig. 5). However, there were no significant differences in CRP, IL-6, VEGF, and IGFBP-3 levels between the open and laparoscopic surgery groups.

Bottom Line: However, objective evidence of its immunologic and oncologic benefits is scarce.Clinical parameters and serum markers were compared.However, there were no significant differences in the preoperative and postoperative levels of CRP, IL-6, VEGF, and IGFBP-3 between the two groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu, Seoul 120-752, Korea.

ABSTRACT

Purpose: Laparoscopic colectomy has clinical benefits such as short hospital stay, less postoperative pain, and early return of bowel function. However, objective evidence of its immunologic and oncologic benefits is scarce. We compared functional recovery after open versus laparoscopic sigmoidectomy and investigated the effect of open versus laparoscopic surgery on acute inflammation as well as tumor stimulation.

Materials and methods: A total of 57 patients who were diagnosed with sigmoid colon cancer were randomized for elective conventional or laparoscopically assisted sigmoidectomy. Serum samples were obtained preoperatively and on postoperative day 1. C-reactive protein (CRP) and interleukin-6 (IL-6) were measured as inflammation markers, and vascular endothelial growth factor (VEGF) and insulin-like growth factor binding protein-3 (IGFBP-3) were used as tumor stimulation factors. Clinical parameters and serum markers were compared.

Results: Postoperative hospital stay (p=0.031), the first day of gas out (p=0.016), and the first day of soft diet (p<0.001) were significantly shorter for the laparoscopic surgery group than the open surgery group. The levels of CRP, IL-6, and VEGF rose significantly, and the concentration of IGFBP-3 fell significantly after both open and laparoscopic surgery. However, there were no significant differences in the preoperative and postoperative levels of CRP, IL-6, VEGF, and IGFBP-3 between the two groups.

Conclusion: Our data suggest that both open and laparoscopic surgeries are accompanied by significant changes in IL-6, CRP, IGFBP-3, and VEGF levels. Acute inflammation markers and tumor stimulating factors may not reflect clinical benefits of laparoscopic surgery.

Show MeSH
Related in: MedlinePlus