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The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid.

Amin KA, Kamel HH, Abd Eltawab MA - Lipids Health Dis (2011)

Bottom Line: These alterations improved by G.Cambogia that decrease BOS and increased NO level.Cambogia, ameliorate the damaging effects of the HFD via lowering feed intake and BOS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Biochemistry Dept, Faculty of Vete, Medicine, Beni-Suef University, Beni-Suef, Egypt. kaamin10@yahoo.com

ABSTRACT

Aims: This study aimed to examine the effect of high fat diet (HFD) to modulate brain dysfunction, and understand the linkages between obesity, metabolic disturbances and the brain oxidative stress (BOS) dysfunction and modulation with hydroxyl citric acid of G. Cambogia.

Methods: Rats were divided into 3 groups; 1st control, maintained on standard normal rat chow diet, 2nd HFD, maintained on high fat diet along 12 week and 3rd HFD+G, administered G. Cambogia for 4 weeks and each group include 8 rats. Blood, brain and abdominal fat were collected for biochemical measurements.

Results: HFD group showed significant increase in energy intake, final BW and BW gain. Also significant increase in weight of abdominal fat in HFD group. HFD induce metabolic disturbance through increasing the lipid profile (LDL, TG, TC), γGT and α-amylase activity, uric acid level and hyperglycemia, while decreasing creatine kinase (CK) activity.These changes associated with lowering in brain nitric oxide (NO) level and rising in serum butyrylcholinesterase (BChE), brain catalase activity and MDA levels as oxidative stress markers. These alterations improved by G. Cambogia that decrease BOS and increased NO level.

Conclusions: Rats fed HFD showed, metabolic disturbances produce hyperglycemia, hypertriglyceridemia, hypercholesterolemia and increased LDL associated with increased BOS. Involvement of BuChE, NO and oxidative stress associated with metabolic disturbances in the pathophysiological progression in brain, suggesting association between obesity, metabolic disorders and brain alteration while, using G. Cambogia, ameliorate the damaging effects of the HFD via lowering feed intake and BOS.

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Related in: MedlinePlus

Means of total energy intake k/calory in total period of experiment (3 months) in different groups of rats. Figure (2) illustrated significant increase in energy intake in HFD compared with control. Values are statistically analyzed by one way ANOVA. Column have different letters indicate significant variation at (P ≤ 0.05), while the same letters indicate non significant variation.
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Figure 2: Means of total energy intake k/calory in total period of experiment (3 months) in different groups of rats. Figure (2) illustrated significant increase in energy intake in HFD compared with control. Values are statistically analyzed by one way ANOVA. Column have different letters indicate significant variation at (P ≤ 0.05), while the same letters indicate non significant variation.

Mentions: In this study, final BW, BW gains (Figure 1) and energy intake (Figure 2) was significantly increased accompanied with significant increase in abdominal adipose tissue (Table 1) in HFD compared with control group. G. Cambogia treatment result in decrease BW, energy intake and adipose tissues in relation to HFD group.


The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid.

Amin KA, Kamel HH, Abd Eltawab MA - Lipids Health Dis (2011)

Means of total energy intake k/calory in total period of experiment (3 months) in different groups of rats. Figure (2) illustrated significant increase in energy intake in HFD compared with control. Values are statistically analyzed by one way ANOVA. Column have different letters indicate significant variation at (P ≤ 0.05), while the same letters indicate non significant variation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104359&req=5

Figure 2: Means of total energy intake k/calory in total period of experiment (3 months) in different groups of rats. Figure (2) illustrated significant increase in energy intake in HFD compared with control. Values are statistically analyzed by one way ANOVA. Column have different letters indicate significant variation at (P ≤ 0.05), while the same letters indicate non significant variation.
Mentions: In this study, final BW, BW gains (Figure 1) and energy intake (Figure 2) was significantly increased accompanied with significant increase in abdominal adipose tissue (Table 1) in HFD compared with control group. G. Cambogia treatment result in decrease BW, energy intake and adipose tissues in relation to HFD group.

Bottom Line: These alterations improved by G.Cambogia that decrease BOS and increased NO level.Cambogia, ameliorate the damaging effects of the HFD via lowering feed intake and BOS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Biochemistry Dept, Faculty of Vete, Medicine, Beni-Suef University, Beni-Suef, Egypt. kaamin10@yahoo.com

ABSTRACT

Aims: This study aimed to examine the effect of high fat diet (HFD) to modulate brain dysfunction, and understand the linkages between obesity, metabolic disturbances and the brain oxidative stress (BOS) dysfunction and modulation with hydroxyl citric acid of G. Cambogia.

Methods: Rats were divided into 3 groups; 1st control, maintained on standard normal rat chow diet, 2nd HFD, maintained on high fat diet along 12 week and 3rd HFD+G, administered G. Cambogia for 4 weeks and each group include 8 rats. Blood, brain and abdominal fat were collected for biochemical measurements.

Results: HFD group showed significant increase in energy intake, final BW and BW gain. Also significant increase in weight of abdominal fat in HFD group. HFD induce metabolic disturbance through increasing the lipid profile (LDL, TG, TC), γGT and α-amylase activity, uric acid level and hyperglycemia, while decreasing creatine kinase (CK) activity.These changes associated with lowering in brain nitric oxide (NO) level and rising in serum butyrylcholinesterase (BChE), brain catalase activity and MDA levels as oxidative stress markers. These alterations improved by G. Cambogia that decrease BOS and increased NO level.

Conclusions: Rats fed HFD showed, metabolic disturbances produce hyperglycemia, hypertriglyceridemia, hypercholesterolemia and increased LDL associated with increased BOS. Involvement of BuChE, NO and oxidative stress associated with metabolic disturbances in the pathophysiological progression in brain, suggesting association between obesity, metabolic disorders and brain alteration while, using G. Cambogia, ameliorate the damaging effects of the HFD via lowering feed intake and BOS.

Show MeSH
Related in: MedlinePlus