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The protective effect of Malva sylvestris on rat kidney damaged by vanadium.

Marouane W, Soussi A, Murat JC, Bezzine S, El Feki A - Lipids Health Dis (2011)

Bottom Line: These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay.A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed.Malva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratoire d’Ecophysiologie Animale, Faculté des Sciences, Route de Soukra 3038 Sfax-University of Sfax-Tunisia.

ABSTRACT

Background: The protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. On the other hand, many medicinal plants are known to possess antioxidant and radical scavenging properties, thanks to the presence of flavonoids. These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay.

Results: In 80 rats exposed to ammonium metavanadate (0.24 mmol/kg body weight in drinking water) for 90 days, lipid peroxidation levels and superoxide dismutase, catalase and glutathione peroxidase activities were measured in kidney. A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed. In addition, a histological examination of kidney revealed a structural deterioration of the renal cortical capsules and a shrinking of the Bowman space. In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats.

Conclusion: Malva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.

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Micrographs of renal sections from controls and treated rats during 30 days. C: control (normal) rats; V: rats treated with vanadium; M: normal rats given Malva sylvestris decoction; MV: vanadium treated rats given Malva sylvestris decoction. (n = 5). Arrows indicate Bowman's space and oedema of interstitial cells.
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Figure 2: Micrographs of renal sections from controls and treated rats during 30 days. C: control (normal) rats; V: rats treated with vanadium; M: normal rats given Malva sylvestris decoction; MV: vanadium treated rats given Malva sylvestris decoction. (n = 5). Arrows indicate Bowman's space and oedema of interstitial cells.

Mentions: The morphologic changes induced in the kidney of treated rats were evaluated after hematoxyline-eosine coloration. Results are presented in Figure 2. Under our experimental conditions, metavanadate poisoning induces 1) a structural deterioration of the renal cortical capsules, 2) a decrease of the Bowman's space, and 3) a hypertrophy of interstitial cells of the limiting membrane of proximal tubules resulting in a reduction of the urinary space. Malva sylvestris decoction appears to prevent these histopathological features.


The protective effect of Malva sylvestris on rat kidney damaged by vanadium.

Marouane W, Soussi A, Murat JC, Bezzine S, El Feki A - Lipids Health Dis (2011)

Micrographs of renal sections from controls and treated rats during 30 days. C: control (normal) rats; V: rats treated with vanadium; M: normal rats given Malva sylvestris decoction; MV: vanadium treated rats given Malva sylvestris decoction. (n = 5). Arrows indicate Bowman's space and oedema of interstitial cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3104358&req=5

Figure 2: Micrographs of renal sections from controls and treated rats during 30 days. C: control (normal) rats; V: rats treated with vanadium; M: normal rats given Malva sylvestris decoction; MV: vanadium treated rats given Malva sylvestris decoction. (n = 5). Arrows indicate Bowman's space and oedema of interstitial cells.
Mentions: The morphologic changes induced in the kidney of treated rats were evaluated after hematoxyline-eosine coloration. Results are presented in Figure 2. Under our experimental conditions, metavanadate poisoning induces 1) a structural deterioration of the renal cortical capsules, 2) a decrease of the Bowman's space, and 3) a hypertrophy of interstitial cells of the limiting membrane of proximal tubules resulting in a reduction of the urinary space. Malva sylvestris decoction appears to prevent these histopathological features.

Bottom Line: These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay.A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed.Malva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratoire d’Ecophysiologie Animale, Faculté des Sciences, Route de Soukra 3038 Sfax-University of Sfax-Tunisia.

ABSTRACT

Background: The protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. On the other hand, many medicinal plants are known to possess antioxidant and radical scavenging properties, thanks to the presence of flavonoids. These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay.

Results: In 80 rats exposed to ammonium metavanadate (0.24 mmol/kg body weight in drinking water) for 90 days, lipid peroxidation levels and superoxide dismutase, catalase and glutathione peroxidase activities were measured in kidney. A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed. In addition, a histological examination of kidney revealed a structural deterioration of the renal cortical capsules and a shrinking of the Bowman space. In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats.

Conclusion: Malva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.

Show MeSH
Related in: MedlinePlus