The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling.
Bottom Line: Here, we develop a general model of protrusion-based patterning to analyse the role of noise in this process.By analysing the effects of introducing thresholds required for signal detection in this model of lateral inhibition, our study shows how filopodia-mediated cell-cell communication can generate complex patterns of spots and stripes, which, in the presence of signalling noise, align themselves across a patterning field.Thus, intermittent protrusion-based signalling has the potential to yield robust self-organizing tissue-wide patterns without the need to invoke diffusion-mediated signalling.
Affiliation: CoMPLEX, University College London, London, UK. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: We recently demonstrated that cell–cell signalling can occur at multiple cell ranges as a result of dynamic filopodial protrusions . Thus, we used our model to investigate the effect of signalling at these ranges of intercellular communication with different inhibition thresholds (T). We simulated the effect of communication via protrusions by incorporating larger neighbour shells (figure 5) into the model. In particular, we investigated the influence of communication between cells separated by one, two or three cells. Figure 5 shows some typical examples of the types of pattern that were seen with and without the influence of signalling noise. For the nearest-neighbour communication model (figure 5a), the emergent patterning is either isolated spots, which optimize their packing under signal noise, or alternatively rings of signalling cells. However, once the signal range extends to two or three cells, a diverse range of spots, clusters, stripes and rings is obtainable (figure 5b,c). As can be observed, the thickness of the emergent clusters or stripes is dependent on the signal threshold; however, as for the fine-grained patterns of spots, their average separation is fixed according to the signalling range. Notably, when noise is implemented, the stripes tend to align themselves with the cell boundaries.Figure 5.
Affiliation: CoMPLEX, University College London, London, UK. firstname.lastname@example.org