The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling.
Bottom Line: Here, we develop a general model of protrusion-based patterning to analyse the role of noise in this process.By analysing the effects of introducing thresholds required for signal detection in this model of lateral inhibition, our study shows how filopodia-mediated cell-cell communication can generate complex patterns of spots and stripes, which, in the presence of signalling noise, align themselves across a patterning field.Thus, intermittent protrusion-based signalling has the potential to yield robust self-organizing tissue-wide patterns without the need to invoke diffusion-mediated signalling.
Affiliation: CoMPLEX, University College London, London, UK. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: The emergent lateral inhibition patterns, such as that shown in figure 2c, quickly stabilize, at which point no further changes in cell state take place. As a result, the final arrangement of active cells is set according to the order in which they were first randomly selected and may be quite irregular (quantified using the coefficient of variation (CV) of pattern spacing, as defined in figure 4c) as long as it fulfils the requirement that no two signalling cells are in direct contact with one another. Although this particular model is highly simplified compared with previous models of lateral inhibition [21,29–31] (which include dynamical descriptions of protein synthesis or gene network interactions), it shares a common feature, in that it generates a pattern of cell states that remains fixed once established. However, as we recently showed by imaging the lateral inhibition in the developing Drosophila notum, in vivo, the process is accompanied by a gradual process of pattern refinement .
Affiliation: CoMPLEX, University College London, London, UK. email@example.com