The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling.
Bottom Line: Here, we develop a general model of protrusion-based patterning to analyse the role of noise in this process.By analysing the effects of introducing thresholds required for signal detection in this model of lateral inhibition, our study shows how filopodia-mediated cell-cell communication can generate complex patterns of spots and stripes, which, in the presence of signalling noise, align themselves across a patterning field.Thus, intermittent protrusion-based signalling has the potential to yield robust self-organizing tissue-wide patterns without the need to invoke diffusion-mediated signalling.
Affiliation: CoMPLEX, University College London, London, UK. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Having previously suggested that signalling noise could be involved in this process of refinement, we next used the CA model of lateral inhibition to consider the effect of signalling noise on the long-term development of patterns by introducing non-binary cell update probabilities into the model. These generalized rules are defined in figure 3a. Two types of ‘structured’ noise were considered in turn, as follows.Figure 3.
Affiliation: CoMPLEX, University College London, London, UK. firstname.lastname@example.org