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White spots on the mucosal surface of the duodenum in dogs with lymphocytic plasmacytic enteritis.

García-Sancho M, Sainz A, Villaescusa A, Rodríguez A, Rodríguez-Franco F - J. Vet. Sci. (2011)

Bottom Line: Distended lacteals, described as expanded white villi in duodenum, are strongly indicative of primary intestinal lymphangiectasia.There was a significant correlation between white spots density and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481).These results suggest that the presence of white spots in the duodenal mucosa of dogs is not a finding exclusive for intestinal lymphangiectasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Medicine and Surgery, College of Veterinary Medicine, Complutense University of Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain. mercgarc@vet.ucm.es

ABSTRACT
Distended lacteals, described as expanded white villi in duodenum, are strongly indicative of primary intestinal lymphangiectasia. In the present study, we evaluated the significance of white spots present in the duodenal mucosa of dogs with lymphocytic plasmacytic enteritis (LPE). Fifty dogs with LPE were included in this study, and white spots were detected in the duodenal mucosa in 22 dogs during endoscopy. Hypoproteinemia was more frequent in dogs with white spots than in dogs without spots (p = 0.02). Serum protein and albumin concentration were significantly lower in LPE dogs with white spots (p = 0.038) compared to LPE dogs without white spots (p = 0.039). There was a significant correlation between white spots density and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481). These results suggest that the presence of white spots in the duodenal mucosa of dogs is not a finding exclusive for intestinal lymphangiectasia. Low serum protein and albumin concentrations together with lymphatic dilatation seem to be related to the presence of white spots in the duodenal mucosa of LPE dogs.

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Histopathological appearance of duodenum showing central lacteal ballooning that represented up to 75% of width of the villous lamina propria on longitudinal section. H&E stain, ×100.
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Figure 2: Histopathological appearance of duodenum showing central lacteal ballooning that represented up to 75% of width of the villous lamina propria on longitudinal section. H&E stain, ×100.

Mentions: The density of the white spots in the duodenal mucosa was graded as mild in 14 dogs (64%; Fig. 1A), moderate in four (18%; Fig. 1B), and severe in four dogs (18%; Fig. 1C). Hypoproteinemia was found in 21% of the dogs (3/14) with mild white spot density, in 25% (1/4) with moderate density, and in 75% (3/4) with severe density. No statistically significant correlation was found between density of white spots and serum protein or albumin concentrations. Likewise, no statistically significant correlation was found between the density of the white spots and either disease activity indices (CIBDAI, p = 0.894; CCECAI, p = 0.076). However, the results showed a statistically significant correlation between density of the white spots and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481; Fig. 2).


White spots on the mucosal surface of the duodenum in dogs with lymphocytic plasmacytic enteritis.

García-Sancho M, Sainz A, Villaescusa A, Rodríguez A, Rodríguez-Franco F - J. Vet. Sci. (2011)

Histopathological appearance of duodenum showing central lacteal ballooning that represented up to 75% of width of the villous lamina propria on longitudinal section. H&E stain, ×100.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3104171&req=5

Figure 2: Histopathological appearance of duodenum showing central lacteal ballooning that represented up to 75% of width of the villous lamina propria on longitudinal section. H&E stain, ×100.
Mentions: The density of the white spots in the duodenal mucosa was graded as mild in 14 dogs (64%; Fig. 1A), moderate in four (18%; Fig. 1B), and severe in four dogs (18%; Fig. 1C). Hypoproteinemia was found in 21% of the dogs (3/14) with mild white spot density, in 25% (1/4) with moderate density, and in 75% (3/4) with severe density. No statistically significant correlation was found between density of white spots and serum protein or albumin concentrations. Likewise, no statistically significant correlation was found between the density of the white spots and either disease activity indices (CIBDAI, p = 0.894; CCECAI, p = 0.076). However, the results showed a statistically significant correlation between density of the white spots and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481; Fig. 2).

Bottom Line: Distended lacteals, described as expanded white villi in duodenum, are strongly indicative of primary intestinal lymphangiectasia.There was a significant correlation between white spots density and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481).These results suggest that the presence of white spots in the duodenal mucosa of dogs is not a finding exclusive for intestinal lymphangiectasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Medicine and Surgery, College of Veterinary Medicine, Complutense University of Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain. mercgarc@vet.ucm.es

ABSTRACT
Distended lacteals, described as expanded white villi in duodenum, are strongly indicative of primary intestinal lymphangiectasia. In the present study, we evaluated the significance of white spots present in the duodenal mucosa of dogs with lymphocytic plasmacytic enteritis (LPE). Fifty dogs with LPE were included in this study, and white spots were detected in the duodenal mucosa in 22 dogs during endoscopy. Hypoproteinemia was more frequent in dogs with white spots than in dogs without spots (p = 0.02). Serum protein and albumin concentration were significantly lower in LPE dogs with white spots (p = 0.038) compared to LPE dogs without white spots (p = 0.039). There was a significant correlation between white spots density and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481). These results suggest that the presence of white spots in the duodenal mucosa of dogs is not a finding exclusive for intestinal lymphangiectasia. Low serum protein and albumin concentrations together with lymphatic dilatation seem to be related to the presence of white spots in the duodenal mucosa of LPE dogs.

Show MeSH
Related in: MedlinePlus