Limits...
Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model.

Kwon JS, Park RK, Shim TJ, Jeong MH, Cho MC, Ahn Y, Kim DW - J. Vet. Sci. (2011)

Bottom Line: Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g).On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group.This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chonnam National University Hospital, Gwanju 501-757, Korea.

ABSTRACT
The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.

Show MeSH

Related in: MedlinePlus

Establishment of a novel aorta stent implantation procedure in rats. Representative illustrations and fluoroscopic angiographs of the implantation of a bare metal stent or paclitaxel-eluting stent in the thoracic aorta. (A) Operation procedure. (B) and (C) Operation procedure involved a guide wire that was advanced in the thoracic aorta after excision of the left common carotid artery and a stent inserted into the thoracic aorta. (D) Follow-up thoracic angiography was performed with a catheter in the right common carotid artery.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3104168&req=5

Figure 1: Establishment of a novel aorta stent implantation procedure in rats. Representative illustrations and fluoroscopic angiographs of the implantation of a bare metal stent or paclitaxel-eluting stent in the thoracic aorta. (A) Operation procedure. (B) and (C) Operation procedure involved a guide wire that was advanced in the thoracic aorta after excision of the left common carotid artery and a stent inserted into the thoracic aorta. (D) Follow-up thoracic angiography was performed with a catheter in the right common carotid artery.

Mentions: Aortography was performed 2 or 4 weeks after stent deployment (Fig. 1A) using a contrast agent (Visipaque; Amersham Health, Ireland). An angiography catheter (18 G radiology needles; BD, USA) was introduced through the right common carotid artery and advanced to the thoracic aorta to deliver the contrast agent. Aorta size was calculated by quantitative angiography before stent implantation. Stent size and balloon pressure were also determined. The stent-to-artery ratio was calculated by dividing the post-implant aorta diameter by the pre-implant aorta diameter.


Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model.

Kwon JS, Park RK, Shim TJ, Jeong MH, Cho MC, Ahn Y, Kim DW - J. Vet. Sci. (2011)

Establishment of a novel aorta stent implantation procedure in rats. Representative illustrations and fluoroscopic angiographs of the implantation of a bare metal stent or paclitaxel-eluting stent in the thoracic aorta. (A) Operation procedure. (B) and (C) Operation procedure involved a guide wire that was advanced in the thoracic aorta after excision of the left common carotid artery and a stent inserted into the thoracic aorta. (D) Follow-up thoracic angiography was performed with a catheter in the right common carotid artery.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3104168&req=5

Figure 1: Establishment of a novel aorta stent implantation procedure in rats. Representative illustrations and fluoroscopic angiographs of the implantation of a bare metal stent or paclitaxel-eluting stent in the thoracic aorta. (A) Operation procedure. (B) and (C) Operation procedure involved a guide wire that was advanced in the thoracic aorta after excision of the left common carotid artery and a stent inserted into the thoracic aorta. (D) Follow-up thoracic angiography was performed with a catheter in the right common carotid artery.
Mentions: Aortography was performed 2 or 4 weeks after stent deployment (Fig. 1A) using a contrast agent (Visipaque; Amersham Health, Ireland). An angiography catheter (18 G radiology needles; BD, USA) was introduced through the right common carotid artery and advanced to the thoracic aorta to deliver the contrast agent. Aorta size was calculated by quantitative angiography before stent implantation. Stent size and balloon pressure were also determined. The stent-to-artery ratio was calculated by dividing the post-implant aorta diameter by the pre-implant aorta diameter.

Bottom Line: Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g).On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group.This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chonnam National University Hospital, Gwanju 501-757, Korea.

ABSTRACT
The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.

Show MeSH
Related in: MedlinePlus