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Hydroxyapatite Mineralization on the Calcium Chloride Blended Polyurethane Nanofiber via Biomimetic Method.

Nirmala R, Nam KT, Navamathavan R, Park SJ, Kim HY - Nanoscale Res Lett (2010)

Bottom Line: SEM images revealed that the CaCl2 salt incorporated homogeneously to form well-oriented nanofibers with smooth surface and uniform diameters along their lengths.The SBF incubation test confirmed the formation of apatite-like materials, exhibiting enhanced bioactive behavior of the polyurethane/CaCl2 composite nanofibers.This study demonstrated that the electrospun polyurethane containing CaCl2 composite nanofibers enhanced the in vitro bioactivity and supports the growth of apatite-like materials.

View Article: PubMed Central - HTML - PubMed

Affiliation: Center for Healthcare Technology and Development, Chonbuk National University, Jeonju 561 756, South Korea. khy@jbnu.ac.kr.

ABSTRACT
Polyurethane nanofibers containing calcium chloride (CaCl2) were prepared via an electrospinning technique for the biomedical applications. Polyurethane nanofibers with different concentration of CaCl2 were electrospun, and their bioactivity evaluation was conducted by incubating in biomimetic simulated body fluid (SBF) solution. The morphology, structure and thermal properties of the polyurethane/CaCl2 composite nanofibers were characterized by means of scanning electron microscopy (SEM), field-emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetry. SEM images revealed that the CaCl2 salt incorporated homogeneously to form well-oriented nanofibers with smooth surface and uniform diameters along their lengths. The SBF incubation test confirmed the formation of apatite-like materials, exhibiting enhanced bioactive behavior of the polyurethane/CaCl2 composite nanofibers. This study demonstrated that the electrospun polyurethane containing CaCl2 composite nanofibers enhanced the in vitro bioactivity and supports the growth of apatite-like materials.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of hydroxyapatite mineralization on polyurethane/CaCl2 composite nanofibers mat.
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Figure 7: Schematic illustration of hydroxyapatite mineralization on polyurethane/CaCl2 composite nanofibers mat.

Mentions: Figure 7 shows the schematic diagram illustrating the experimental process of the mineralization of hydroxyapatite on the polyurethane/CaCl2 composite nanofibers during immersion in SBF. The presence of calcium in polyurethane nanofibers accelerates the formation of apatite aggregation during incubation in the SBF solution. Development of the apatite-like materials on the polyurethane/CaCl2 composite nanofiber surface depends on the presence of nucleation sites and sufficient concentration of ionic species necessary to form the apatite. Relatively high specific surface area of the rugged calcium ions on the surfaces of the polyurethane/CaCl2 composite nanofibers provides the nucleation sites for apatite in SBF compared with pristine polyurethane nanofibers, results in more energetic nucleation sites. When a nucleus forms on the calcium ions, the contact area between nanofiber surface and nucleus is small enough such that a preferred orientation growth habit is active and initiates faster growth. Consequently, a large number of apatite nuclei are formed on the polyurethane/CaCl2 composite nanofibers surface. Then, the ions necessary for the growth can diffuse to the nucleation site from all directions and provide many nucleation sites resulting in spherical bunches of apatite-like material growth [see Figure 2a4]. Thus in the development of the biomimetic reaction on the polyurethane/CaCl2 composite nanofibers, the bone-like apatite crystals appear to be formed via intermediate products of calcium phosphate. The result demonstrated the fast nucleation of apatite-like materials with increasing concentration of CaCl2 in polyurethane composite nanofibers, which can be utilized for the guided bone regeneration membrane.


Hydroxyapatite Mineralization on the Calcium Chloride Blended Polyurethane Nanofiber via Biomimetic Method.

Nirmala R, Nam KT, Navamathavan R, Park SJ, Kim HY - Nanoscale Res Lett (2010)

Schematic illustration of hydroxyapatite mineralization on polyurethane/CaCl2 composite nanofibers mat.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3102341&req=5

Figure 7: Schematic illustration of hydroxyapatite mineralization on polyurethane/CaCl2 composite nanofibers mat.
Mentions: Figure 7 shows the schematic diagram illustrating the experimental process of the mineralization of hydroxyapatite on the polyurethane/CaCl2 composite nanofibers during immersion in SBF. The presence of calcium in polyurethane nanofibers accelerates the formation of apatite aggregation during incubation in the SBF solution. Development of the apatite-like materials on the polyurethane/CaCl2 composite nanofiber surface depends on the presence of nucleation sites and sufficient concentration of ionic species necessary to form the apatite. Relatively high specific surface area of the rugged calcium ions on the surfaces of the polyurethane/CaCl2 composite nanofibers provides the nucleation sites for apatite in SBF compared with pristine polyurethane nanofibers, results in more energetic nucleation sites. When a nucleus forms on the calcium ions, the contact area between nanofiber surface and nucleus is small enough such that a preferred orientation growth habit is active and initiates faster growth. Consequently, a large number of apatite nuclei are formed on the polyurethane/CaCl2 composite nanofibers surface. Then, the ions necessary for the growth can diffuse to the nucleation site from all directions and provide many nucleation sites resulting in spherical bunches of apatite-like material growth [see Figure 2a4]. Thus in the development of the biomimetic reaction on the polyurethane/CaCl2 composite nanofibers, the bone-like apatite crystals appear to be formed via intermediate products of calcium phosphate. The result demonstrated the fast nucleation of apatite-like materials with increasing concentration of CaCl2 in polyurethane composite nanofibers, which can be utilized for the guided bone regeneration membrane.

Bottom Line: SEM images revealed that the CaCl2 salt incorporated homogeneously to form well-oriented nanofibers with smooth surface and uniform diameters along their lengths.The SBF incubation test confirmed the formation of apatite-like materials, exhibiting enhanced bioactive behavior of the polyurethane/CaCl2 composite nanofibers.This study demonstrated that the electrospun polyurethane containing CaCl2 composite nanofibers enhanced the in vitro bioactivity and supports the growth of apatite-like materials.

View Article: PubMed Central - HTML - PubMed

Affiliation: Center for Healthcare Technology and Development, Chonbuk National University, Jeonju 561 756, South Korea. khy@jbnu.ac.kr.

ABSTRACT
Polyurethane nanofibers containing calcium chloride (CaCl2) were prepared via an electrospinning technique for the biomedical applications. Polyurethane nanofibers with different concentration of CaCl2 were electrospun, and their bioactivity evaluation was conducted by incubating in biomimetic simulated body fluid (SBF) solution. The morphology, structure and thermal properties of the polyurethane/CaCl2 composite nanofibers were characterized by means of scanning electron microscopy (SEM), field-emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetry. SEM images revealed that the CaCl2 salt incorporated homogeneously to form well-oriented nanofibers with smooth surface and uniform diameters along their lengths. The SBF incubation test confirmed the formation of apatite-like materials, exhibiting enhanced bioactive behavior of the polyurethane/CaCl2 composite nanofibers. This study demonstrated that the electrospun polyurethane containing CaCl2 composite nanofibers enhanced the in vitro bioactivity and supports the growth of apatite-like materials.

No MeSH data available.


Related in: MedlinePlus