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Harnessing neuroplasticity for clinical applications.

Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S - Brain (2011)

Bottom Line: Neuroplasticity occurs with many variations, in many forms, and in many contexts.However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention.Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, UC Irvine Medical Centre, 101 The City Drive South, Bldg 53, Rm 203, Orange, CA 92868-4280, USA. scramer@uci.edu

ABSTRACT
Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in the understanding of neuroplasticity have to date yielded few established interventions. To advance the translation of neuroplasticity research towards clinical applications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in 2009. Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators. Promising therapies that may enhance training-induced cognitive and motor learning, such as brain stimulation and neuropharmacological interventions, were identified, along with questions of how best to use this body of information to reduce human disability. Improved understanding of adaptive mechanisms at every level, from molecules to synapses, to networks, to behaviour, can be gained from iterative collaborations between basic and clinical researchers. Lessons can be gleaned from studying fields related to plasticity, such as development, critical periods, learning and response to disease. Improved means of assessing neuroplasticity in humans, including biomarkers for predicting and monitoring treatment response, are needed. Neuroplasticity occurs with many variations, in many forms, and in many contexts. However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention. Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies.

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Conceptual overview of the relationship between clinical phenotypes, neuroplasticity, therapeutic interventions and assessment of function.
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Figure 1: Conceptual overview of the relationship between clinical phenotypes, neuroplasticity, therapeutic interventions and assessment of function.

Mentions: Twenty-seven leading scientists participated in a 2009 workshop sponsored by the National Institutes of Health Blueprint for Neuroscience Research, organized to promote opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies. Included were experts in neurotrauma and stroke, mental and addictive disorders, paediatric and developmental disorders and neurodegeneration and ageing. The participants identified cardinal examples of human neuroplasticity in these conditions, underlying biological substrates and mechanisms, promising interventions for promoting adaptive neuroplastic changes and measures for evaluating neuroplastic capacity and monitoring circuit engagement and reorganization. The current report surveys neuroplastic adaptations across clinical phenotypes and highlights a number of broad themes and potential future directions that may produce therapeutic interventions to reduce disability across a range of conditions (Fig. 1).Figure 1


Harnessing neuroplasticity for clinical applications.

Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S - Brain (2011)

Conceptual overview of the relationship between clinical phenotypes, neuroplasticity, therapeutic interventions and assessment of function.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3102236&req=5

Figure 1: Conceptual overview of the relationship between clinical phenotypes, neuroplasticity, therapeutic interventions and assessment of function.
Mentions: Twenty-seven leading scientists participated in a 2009 workshop sponsored by the National Institutes of Health Blueprint for Neuroscience Research, organized to promote opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies. Included were experts in neurotrauma and stroke, mental and addictive disorders, paediatric and developmental disorders and neurodegeneration and ageing. The participants identified cardinal examples of human neuroplasticity in these conditions, underlying biological substrates and mechanisms, promising interventions for promoting adaptive neuroplastic changes and measures for evaluating neuroplastic capacity and monitoring circuit engagement and reorganization. The current report surveys neuroplastic adaptations across clinical phenotypes and highlights a number of broad themes and potential future directions that may produce therapeutic interventions to reduce disability across a range of conditions (Fig. 1).Figure 1

Bottom Line: Neuroplasticity occurs with many variations, in many forms, and in many contexts.However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention.Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, UC Irvine Medical Centre, 101 The City Drive South, Bldg 53, Rm 203, Orange, CA 92868-4280, USA. scramer@uci.edu

ABSTRACT
Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in the understanding of neuroplasticity have to date yielded few established interventions. To advance the translation of neuroplasticity research towards clinical applications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in 2009. Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators. Promising therapies that may enhance training-induced cognitive and motor learning, such as brain stimulation and neuropharmacological interventions, were identified, along with questions of how best to use this body of information to reduce human disability. Improved understanding of adaptive mechanisms at every level, from molecules to synapses, to networks, to behaviour, can be gained from iterative collaborations between basic and clinical researchers. Lessons can be gleaned from studying fields related to plasticity, such as development, critical periods, learning and response to disease. Improved means of assessing neuroplasticity in humans, including biomarkers for predicting and monitoring treatment response, are needed. Neuroplasticity occurs with many variations, in many forms, and in many contexts. However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention. Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies.

Show MeSH
Related in: MedlinePlus