Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity.
Bottom Line: There was a negative correlation between verbal fluency and σ; no correlation was found between motor function and any of the latency parameters.Higher μ (shorter latency) positively correlated with grey matter volume in the prefrontal cortex, the cerebellar vermis, and the fusiform gyrus.Our behavioural and imaging findings point to an association between saccade latency, executive function and the structural integrity within a well-defined oculomotor network.
Affiliation: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany. email@example.comShow MeSH
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Mentions: In patients, σΕ correlated negatively with grey matter volume in the frontal eye fields, the precuneus, the middle frontal gyrus, and the prestriate cortex (p < 0.05 FWE corrected; Fig. 4A and Table S3 in Supplement 1). With the exception of the prestriate cortex, these associations were located in regions with a trend towards grey matter loss in patients versus controls (p < 0.05 uncorrected). In the control group, σΕ was negatively correlated with grey matter volume in the premotor cortex only (p < 0.05 FWE corrected; Fig. 4B and Table S3 in Supplement 1).
Affiliation: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany. firstname.lastname@example.org