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Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity.

Perneczky R, Ghosh BC, Hughes L, Carpenter RH, Barker RA, Rowe JB - Neurobiol. Dis. (2011)

Bottom Line: There was a negative correlation between verbal fluency and σ; no correlation was found between motor function and any of the latency parameters.There was a negative correlation between σ and grey matter volume in the frontal and parietal eye fields, the premotor cortex, and the lateral prefrontal cortex. σ(E) negatively correlated with grey matter volume in the frontal eye fields and the middle frontal gyrus.Our behavioural and imaging findings point to an association between saccade latency, executive function and the structural integrity within a well-defined oculomotor network.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany. robert.perneczky@lrz.tum.de

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SPM{t} maps of voxelwise correlations between grey matter volume and the variability of the early saccade population (σE) in patients (A) and controls (B). Anatomical localization as projected on axial sections of a normal MRI, spatially normalised into the MNI template (p < 0.05, FWE corrected for multiple comparisons) at the given z coordinates in MNI space. Sub-plots show group mean-corrected σE vs. grey matter correlation data for controls (blue) and patients (red).
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f0020: SPM{t} maps of voxelwise correlations between grey matter volume and the variability of the early saccade population (σE) in patients (A) and controls (B). Anatomical localization as projected on axial sections of a normal MRI, spatially normalised into the MNI template (p < 0.05, FWE corrected for multiple comparisons) at the given z coordinates in MNI space. Sub-plots show group mean-corrected σE vs. grey matter correlation data for controls (blue) and patients (red).

Mentions: In patients, σΕ correlated negatively with grey matter volume in the frontal eye fields, the precuneus, the middle frontal gyrus, and the prestriate cortex (p < 0.05 FWE corrected; Fig. 4A and Table S3 in Supplement 1). With the exception of the prestriate cortex, these associations were located in regions with a trend towards grey matter loss in patients versus controls (p < 0.05 uncorrected). In the control group, σΕ was negatively correlated with grey matter volume in the premotor cortex only (p < 0.05 FWE corrected; Fig. 4B and Table S3 in Supplement 1).


Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity.

Perneczky R, Ghosh BC, Hughes L, Carpenter RH, Barker RA, Rowe JB - Neurobiol. Dis. (2011)

SPM{t} maps of voxelwise correlations between grey matter volume and the variability of the early saccade population (σE) in patients (A) and controls (B). Anatomical localization as projected on axial sections of a normal MRI, spatially normalised into the MNI template (p < 0.05, FWE corrected for multiple comparisons) at the given z coordinates in MNI space. Sub-plots show group mean-corrected σE vs. grey matter correlation data for controls (blue) and patients (red).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3102178&req=5

f0020: SPM{t} maps of voxelwise correlations between grey matter volume and the variability of the early saccade population (σE) in patients (A) and controls (B). Anatomical localization as projected on axial sections of a normal MRI, spatially normalised into the MNI template (p < 0.05, FWE corrected for multiple comparisons) at the given z coordinates in MNI space. Sub-plots show group mean-corrected σE vs. grey matter correlation data for controls (blue) and patients (red).
Mentions: In patients, σΕ correlated negatively with grey matter volume in the frontal eye fields, the precuneus, the middle frontal gyrus, and the prestriate cortex (p < 0.05 FWE corrected; Fig. 4A and Table S3 in Supplement 1). With the exception of the prestriate cortex, these associations were located in regions with a trend towards grey matter loss in patients versus controls (p < 0.05 uncorrected). In the control group, σΕ was negatively correlated with grey matter volume in the premotor cortex only (p < 0.05 FWE corrected; Fig. 4B and Table S3 in Supplement 1).

Bottom Line: There was a negative correlation between verbal fluency and σ; no correlation was found between motor function and any of the latency parameters.There was a negative correlation between σ and grey matter volume in the frontal and parietal eye fields, the premotor cortex, and the lateral prefrontal cortex. σ(E) negatively correlated with grey matter volume in the frontal eye fields and the middle frontal gyrus.Our behavioural and imaging findings point to an association between saccade latency, executive function and the structural integrity within a well-defined oculomotor network.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany. robert.perneczky@lrz.tum.de

Show MeSH
Related in: MedlinePlus