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Clinicopathological characteristics and her-2/neu status in chinese patients with uterine papillary serous carcinoma.

Ren Y, Wang H, Zhou X, Yang W, Huang X, Lu Y, Shi D - ISRN Obstet Gynecol (2010)

Bottom Line: Methods.Her-2/neu protein expression 2 + ∼3+ was significantly associated with advanced surgical stage and worse overall survival (P = .03 and P = .0023, resp.).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, China.

ABSTRACT
Objective. To analyze clinico-pathological features of Chinese patients with UPSC, and investigate roles of Her-2/neu protein expression and gene amplification in UPSC prognosis. Methods. Thirty-six patients with UPSC treated in Cancer Hospital of Fudan University from 1996 to 2006 were analysed retrospectively. Chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) were performed to evaluate Her-2/neu gene amplification and protein expression respectively. Results. The median age was 63 years, and 61% (22/36) were late stages (stage III/IV). The 1-year, 3-year, and 5-year overall survival (OS) was 73.1%, 51.9% and 43.9%, respectively. Advanced stages (P = .0006) and deep myometrial invasion (P = .0138) were significantly associtated with a shorter OS. In 36 cases, 27.8% (10/36) showed 2+ staining and 8.3% (3/36) showed 3+ by IHC. Amplification of the Her-2/neu gene was observed in 11.1% (4/36) cases. The 5-year overall survival rate in Her-2/neu IHC 2 + ∼3+ and 0 ~ 1+ cases was 12.9% and 68.6% respectively. Her-2/neu protein expression 2 + ∼3+ was significantly associated with advanced surgical stage and worse overall survival (P = .03 and P = .0023, resp.). Conclusion. Chinese patients with UPSC showed characteristics of deep myometrial invasion, advanced stages and poor overall survival. Her-2/neu protein overexpression is associated with advanced stage and poor survival outcome.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curve based on myometrial invasion (≥1/2 versus <1/2, P = .0138).
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fig5: Kaplan-Meier curve based on myometrial invasion (≥1/2 versus <1/2, P = .0138).

Mentions: The results of univariate survival analysis of Her-2/neu protein expression and other clinicopathological factors are shown in Table 3. The 5-year overall survival rate for Her-2/neu IHC positive and negative cases was 12.9% and 68.6%, respectively. Poorer outcome (Kaplan–Meier) was observed for patients with Her-2/neu overexpression positive than negative patients (P = .0023) (Figure 3). The 5-year overall survival rate for early and advanced stage cases was 60.4% and 16%, respectively. Advanced stages (P = .0006) and deep myometrial invasion (P = .0138) were also significantly associtated with a shorter OS (Figures 4 and 5).


Clinicopathological characteristics and her-2/neu status in chinese patients with uterine papillary serous carcinoma.

Ren Y, Wang H, Zhou X, Yang W, Huang X, Lu Y, Shi D - ISRN Obstet Gynecol (2010)

Kaplan-Meier curve based on myometrial invasion (≥1/2 versus <1/2, P = .0138).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3102014&req=5

fig5: Kaplan-Meier curve based on myometrial invasion (≥1/2 versus <1/2, P = .0138).
Mentions: The results of univariate survival analysis of Her-2/neu protein expression and other clinicopathological factors are shown in Table 3. The 5-year overall survival rate for Her-2/neu IHC positive and negative cases was 12.9% and 68.6%, respectively. Poorer outcome (Kaplan–Meier) was observed for patients with Her-2/neu overexpression positive than negative patients (P = .0023) (Figure 3). The 5-year overall survival rate for early and advanced stage cases was 60.4% and 16%, respectively. Advanced stages (P = .0006) and deep myometrial invasion (P = .0138) were also significantly associtated with a shorter OS (Figures 4 and 5).

Bottom Line: Methods.Her-2/neu protein expression 2 + ∼3+ was significantly associated with advanced surgical stage and worse overall survival (P = .03 and P = .0023, resp.).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, China.

ABSTRACT
Objective. To analyze clinico-pathological features of Chinese patients with UPSC, and investigate roles of Her-2/neu protein expression and gene amplification in UPSC prognosis. Methods. Thirty-six patients with UPSC treated in Cancer Hospital of Fudan University from 1996 to 2006 were analysed retrospectively. Chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) were performed to evaluate Her-2/neu gene amplification and protein expression respectively. Results. The median age was 63 years, and 61% (22/36) were late stages (stage III/IV). The 1-year, 3-year, and 5-year overall survival (OS) was 73.1%, 51.9% and 43.9%, respectively. Advanced stages (P = .0006) and deep myometrial invasion (P = .0138) were significantly associtated with a shorter OS. In 36 cases, 27.8% (10/36) showed 2+ staining and 8.3% (3/36) showed 3+ by IHC. Amplification of the Her-2/neu gene was observed in 11.1% (4/36) cases. The 5-year overall survival rate in Her-2/neu IHC 2 + ∼3+ and 0 ~ 1+ cases was 12.9% and 68.6% respectively. Her-2/neu protein expression 2 + ∼3+ was significantly associated with advanced surgical stage and worse overall survival (P = .03 and P = .0023, resp.). Conclusion. Chinese patients with UPSC showed characteristics of deep myometrial invasion, advanced stages and poor overall survival. Her-2/neu protein overexpression is associated with advanced stage and poor survival outcome.

No MeSH data available.


Related in: MedlinePlus