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Primary malignant melanoma of the uterine cervix treated with ultraradical surgery: a case report.

Calderón-Salazar L, Cantú de Leon D, Perez Montiel D, Almogabar-Villagrán E, Villavicencio V, Cetina L - ISRN Obstet Gynecol (2010)

Bottom Line: The patient was under surveillance for 8 years of followup without evidence of local or distant disease.The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients.Notwithstanding this, survival is very short when patients are treated in this manner.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecologic Oncology, Instituto Nacional de Cancerologia, 14080 Mèxico, Mexico.

ABSTRACT
Primary melanomas of the uterine cervix are rare tumors with no more than 60 cases reported in the world literature. Poor prognosis is considered for the neoplasia itself as well as for diagnostic tardiness. There is no standard treatment; however, radical surgery is the treatment cornerstone. Our aim was to present the case of a 34-year-old woman with a primary malignant melanoma in the uterine cervix with affectation of the posterior face of the vagina without metastasis. Total infraelevator pelvic exenteration and adjuvant radiotherapy was performed. The patient was under surveillance for 8 years of followup without evidence of local or distant disease. The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients. Notwithstanding this, survival is very short when patients are treated in this manner. Based on our results and on those reported in the literature, we propose initial treatment with total pelvic exenteration as optimal management for this neoplasia in its initial form.

No MeSH data available.


Related in: MedlinePlus

Microscopic picture showing a medium power view of the lesion. (HE 10x) in the box Melan A reaction diffuse positive.
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fig2: Microscopic picture showing a medium power view of the lesion. (HE 10x) in the box Melan A reaction diffuse positive.

Mentions: For histopathological studies, the product of the total pelvic exenteration was received, in which a neoplastic lesion of the cervix measured 7.5 × 5.5 cm with involvement of the upper third of the vagina into anterior vaginal septum. The neoplasia was polypoid and light brown in color with necrosis. Microscopically, the neoplasia was formed by nodules of broad cytoplasmic cells with poorly defined borders with pleomorphic nuclei with prominent nucleolae. These areas displayed transition with areas with fascicules of elongated cells of moderate cytoplasm and similar elongated nuclei to those described previously (Figure 2).


Primary malignant melanoma of the uterine cervix treated with ultraradical surgery: a case report.

Calderón-Salazar L, Cantú de Leon D, Perez Montiel D, Almogabar-Villagrán E, Villavicencio V, Cetina L - ISRN Obstet Gynecol (2010)

Microscopic picture showing a medium power view of the lesion. (HE 10x) in the box Melan A reaction diffuse positive.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3101984&req=5

fig2: Microscopic picture showing a medium power view of the lesion. (HE 10x) in the box Melan A reaction diffuse positive.
Mentions: For histopathological studies, the product of the total pelvic exenteration was received, in which a neoplastic lesion of the cervix measured 7.5 × 5.5 cm with involvement of the upper third of the vagina into anterior vaginal septum. The neoplasia was polypoid and light brown in color with necrosis. Microscopically, the neoplasia was formed by nodules of broad cytoplasmic cells with poorly defined borders with pleomorphic nuclei with prominent nucleolae. These areas displayed transition with areas with fascicules of elongated cells of moderate cytoplasm and similar elongated nuclei to those described previously (Figure 2).

Bottom Line: The patient was under surveillance for 8 years of followup without evidence of local or distant disease.The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients.Notwithstanding this, survival is very short when patients are treated in this manner.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecologic Oncology, Instituto Nacional de Cancerologia, 14080 Mèxico, Mexico.

ABSTRACT
Primary melanomas of the uterine cervix are rare tumors with no more than 60 cases reported in the world literature. Poor prognosis is considered for the neoplasia itself as well as for diagnostic tardiness. There is no standard treatment; however, radical surgery is the treatment cornerstone. Our aim was to present the case of a 34-year-old woman with a primary malignant melanoma in the uterine cervix with affectation of the posterior face of the vagina without metastasis. Total infraelevator pelvic exenteration and adjuvant radiotherapy was performed. The patient was under surveillance for 8 years of followup without evidence of local or distant disease. The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients. Notwithstanding this, survival is very short when patients are treated in this manner. Based on our results and on those reported in the literature, we propose initial treatment with total pelvic exenteration as optimal management for this neoplasia in its initial form.

No MeSH data available.


Related in: MedlinePlus