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Fluid intake and incidence of renal cell carcinoma in UK women.

Allen NE, Balkwill A, Beral V, Green J, Reeves G, Million Women Study Collaborato - Br. J. Cancer (2011)

Bottom Line: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study.Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index.While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages.

View Article: PubMed Central - PubMed

Affiliation: Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK. naomi.allen@ceu.ox.ac.uk

ABSTRACT

Background: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women.

Methods: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index.

Results: After an average of 5.2 years of follow-up, 588 cases of renal cell carcinoma were identified among 779,369 women. While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages.

Conclusions: The apparent protective effect of alcohol on the risk of renal cell carcinoma is unlikely to be related to a high fluid intake.

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Related in: MedlinePlus

Multivariate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma per drink per day increase according to various characteristics of the women studied.
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fig2: Multivariate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma per drink per day increase according to various characteristics of the women studied.

Mentions: Table 2 shows the risk of renal cell carcinoma associated with consumption of total fluids. Overall, consumption of total fluids was not associated with risk; compared with women who drank <7 drinks per day, the RRs for women who drank 8–9, 10–11, and ⩾12 drinks per day were 1.13 (95% confidence interval (CI): 0.89–1.42), 1.06 (95% CI: 0.83–1.35), and 1.15 (95% CI: 0.91–1.45), respectively (P for trend=0.3). Figure 2 shows the association of total fluid intake and risk of renal cell carcinoma by smoking status, body mass index, and time between completing the questionnaire and diagnosis, none of which modified the overall association.


Fluid intake and incidence of renal cell carcinoma in UK women.

Allen NE, Balkwill A, Beral V, Green J, Reeves G, Million Women Study Collaborato - Br. J. Cancer (2011)

Multivariate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma per drink per day increase according to various characteristics of the women studied.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3101943&req=5

fig2: Multivariate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma per drink per day increase according to various characteristics of the women studied.
Mentions: Table 2 shows the risk of renal cell carcinoma associated with consumption of total fluids. Overall, consumption of total fluids was not associated with risk; compared with women who drank <7 drinks per day, the RRs for women who drank 8–9, 10–11, and ⩾12 drinks per day were 1.13 (95% confidence interval (CI): 0.89–1.42), 1.06 (95% CI: 0.83–1.35), and 1.15 (95% CI: 0.91–1.45), respectively (P for trend=0.3). Figure 2 shows the association of total fluid intake and risk of renal cell carcinoma by smoking status, body mass index, and time between completing the questionnaire and diagnosis, none of which modified the overall association.

Bottom Line: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study.Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index.While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages.

View Article: PubMed Central - PubMed

Affiliation: Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK. naomi.allen@ceu.ox.ac.uk

ABSTRACT

Background: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women.

Methods: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index.

Results: After an average of 5.2 years of follow-up, 588 cases of renal cell carcinoma were identified among 779,369 women. While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages.

Conclusions: The apparent protective effect of alcohol on the risk of renal cell carcinoma is unlikely to be related to a high fluid intake.

Show MeSH
Related in: MedlinePlus