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Comparative study of attenuation of the pain caused by propofol intravenous injection, by granisetron, magnesium sulfate and nitroglycerine.

Singh DK, Jindal P, Singh G - Saudi J Anaesth (2011)

Bottom Line: A score of 0-3 which corresponds to no, mild, moderate and severe pain was recorded.All the three drugs reduced the incidence and intensity of pain on propofol injection but the order of efficacy in attenuation of pain on the propofol injection was granisetron > nitroglycerine > magnesium sulfate > control.Granisetron was the most effective followed by nitroglycerine and magnesium sulfate in attenuating pain on propofol intravenous injection.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology, Pain Management & ICU, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, India.

ABSTRACT

Background: Propofol has the disadvantage of causing pain or discomfort on injection. The aim of the study was to assess the efficacy of pretreatment with various drugs to alleviate the propofol injection pain.

Methods: One hundred American Society of Anesthesiology (ASA) I and II adults, scheduled for various elective surgical procedures under general anesthesia (GA), were included in the study. They were randomly divided into four groups having 25 patients in each group. Group A received pretreatment with intravenous (i.v.) magnesium sulfate, group B received i.v. granisetron, group C received i.v. nitroglycerine and group D was the control group. One-fourth of the total calculated induction dose of propofol was administered over a period of 5 seconds. The patients were asked about the pain on injection. The intensity of pain was assessed using verbal response. A score of 0-3 which corresponds to no, mild, moderate and severe pain was recorded.

Results: All the three drugs reduced the incidence and intensity of pain on propofol injection but the order of efficacy in attenuation of pain on the propofol injection was granisetron > nitroglycerine > magnesium sulfate > control.

Conclusion: Granisetron was the most effective followed by nitroglycerine and magnesium sulfate in attenuating pain on propofol intravenous injection.

No MeSH data available.


Related in: MedlinePlus

Pain score of patients at 20 seconds
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Figure 0004: Pain score of patients at 20 seconds

Mentions: The number of patients with grade 0 pain at 15 seconds was 5, 15, 9 and 3 in groups A, B, C and D, respectively. There were no significant statistical differences when groups A, B and C were compared among themselves [Figure 3]. The number of patients with grade 0 pain at 20 seconds was 5, 15, 9 and 3 in groups A, B, C and D, respectively. When group A was compared with groups B and C, there was significant difference but on comparing group B and group C (P > 0.05), there was no significant statistical difference. Statistical analysis (P < 0.05) among all the three groups – groups A, B and C was highly significant [Figure 4]. The order of efficacy of drugs at different time intervals is summarized in [Table 2].


Comparative study of attenuation of the pain caused by propofol intravenous injection, by granisetron, magnesium sulfate and nitroglycerine.

Singh DK, Jindal P, Singh G - Saudi J Anaesth (2011)

Pain score of patients at 20 seconds
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3101754&req=5

Figure 0004: Pain score of patients at 20 seconds
Mentions: The number of patients with grade 0 pain at 15 seconds was 5, 15, 9 and 3 in groups A, B, C and D, respectively. There were no significant statistical differences when groups A, B and C were compared among themselves [Figure 3]. The number of patients with grade 0 pain at 20 seconds was 5, 15, 9 and 3 in groups A, B, C and D, respectively. When group A was compared with groups B and C, there was significant difference but on comparing group B and group C (P > 0.05), there was no significant statistical difference. Statistical analysis (P < 0.05) among all the three groups – groups A, B and C was highly significant [Figure 4]. The order of efficacy of drugs at different time intervals is summarized in [Table 2].

Bottom Line: A score of 0-3 which corresponds to no, mild, moderate and severe pain was recorded.All the three drugs reduced the incidence and intensity of pain on propofol injection but the order of efficacy in attenuation of pain on the propofol injection was granisetron > nitroglycerine > magnesium sulfate > control.Granisetron was the most effective followed by nitroglycerine and magnesium sulfate in attenuating pain on propofol intravenous injection.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology, Pain Management & ICU, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, India.

ABSTRACT

Background: Propofol has the disadvantage of causing pain or discomfort on injection. The aim of the study was to assess the efficacy of pretreatment with various drugs to alleviate the propofol injection pain.

Methods: One hundred American Society of Anesthesiology (ASA) I and II adults, scheduled for various elective surgical procedures under general anesthesia (GA), were included in the study. They were randomly divided into four groups having 25 patients in each group. Group A received pretreatment with intravenous (i.v.) magnesium sulfate, group B received i.v. granisetron, group C received i.v. nitroglycerine and group D was the control group. One-fourth of the total calculated induction dose of propofol was administered over a period of 5 seconds. The patients were asked about the pain on injection. The intensity of pain was assessed using verbal response. A score of 0-3 which corresponds to no, mild, moderate and severe pain was recorded.

Results: All the three drugs reduced the incidence and intensity of pain on propofol injection but the order of efficacy in attenuation of pain on the propofol injection was granisetron > nitroglycerine > magnesium sulfate > control.

Conclusion: Granisetron was the most effective followed by nitroglycerine and magnesium sulfate in attenuating pain on propofol intravenous injection.

No MeSH data available.


Related in: MedlinePlus