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Hyalinizing spindle cell tumor with giant rosettes.

Ramaswamy AS, Chatura KR - Ann Saudi Med (2011 Jan-Feb)

Bottom Line: Recurrences are common, and late metastases have been recorded.Because of the similarities, both lesions are considered to be a single entity within the spectrum of low-grade sarcomas.Two cases of HSCTGR occurring in the lower limb are described in this report.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, People's Education Society Institute of Medical Sciences and Research, Kuppam, India.

ABSTRACT
Low-grade fibromyxoid sarcomas are uncommon deep-seated soft tissue neoplasms that exhibit a deceptively benign appearance microscopically. The finding of a linear or whorled array of spindled cells with few or no mitoses in a characteristic myxoid stroma can pose diagnostic dilemmas. Recurrences are common, and late metastases have been recorded. A closely related tumor, the so-called hyalinizing spindle cell tumor with giant collagen rosettes (HSCTGR), has also been described, with both the neoplasms having a similar cytogenetic abnormality and clinical behavior. Because of the similarities, both lesions are considered to be a single entity within the spectrum of low-grade sarcomas. Two cases of HSCTGR occurring in the lower limb are described in this report.

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S-100 positivity in the rounded cells present in the cellular cuff of the giant rosettes (hematoxylin and eosin, ×40).
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Figure 0006: S-100 positivity in the rounded cells present in the cellular cuff of the giant rosettes (hematoxylin and eosin, ×40).

Mentions: Immunohistochemically, both the spindle-shaped and ovoid cells stained strongly for vimentin. S-100 was frequently positive in the rounded cells (Figure 6). The spindle-shaped cells stained negative for S-100. Negativity for S-100 militates against the diagnosis of schwannoma and strongly favors a diagnosis of HSCTGR. The above conglomeration of histomorphological and immunohistochemical features led us to the diagnosis of HSCTGR.Figure 6


Hyalinizing spindle cell tumor with giant rosettes.

Ramaswamy AS, Chatura KR - Ann Saudi Med (2011 Jan-Feb)

S-100 positivity in the rounded cells present in the cellular cuff of the giant rosettes (hematoxylin and eosin, ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3101732&req=5

Figure 0006: S-100 positivity in the rounded cells present in the cellular cuff of the giant rosettes (hematoxylin and eosin, ×40).
Mentions: Immunohistochemically, both the spindle-shaped and ovoid cells stained strongly for vimentin. S-100 was frequently positive in the rounded cells (Figure 6). The spindle-shaped cells stained negative for S-100. Negativity for S-100 militates against the diagnosis of schwannoma and strongly favors a diagnosis of HSCTGR. The above conglomeration of histomorphological and immunohistochemical features led us to the diagnosis of HSCTGR.Figure 6

Bottom Line: Recurrences are common, and late metastases have been recorded.Because of the similarities, both lesions are considered to be a single entity within the spectrum of low-grade sarcomas.Two cases of HSCTGR occurring in the lower limb are described in this report.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, People's Education Society Institute of Medical Sciences and Research, Kuppam, India.

ABSTRACT
Low-grade fibromyxoid sarcomas are uncommon deep-seated soft tissue neoplasms that exhibit a deceptively benign appearance microscopically. The finding of a linear or whorled array of spindled cells with few or no mitoses in a characteristic myxoid stroma can pose diagnostic dilemmas. Recurrences are common, and late metastases have been recorded. A closely related tumor, the so-called hyalinizing spindle cell tumor with giant collagen rosettes (HSCTGR), has also been described, with both the neoplasms having a similar cytogenetic abnormality and clinical behavior. Because of the similarities, both lesions are considered to be a single entity within the spectrum of low-grade sarcomas. Two cases of HSCTGR occurring in the lower limb are described in this report.

Show MeSH
Related in: MedlinePlus