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OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis.

Farres MN, Al-Zifzaf DS, Aly AA, Abd Raboh NM - Ann Saudi Med (2011 Jan-Feb)

Bottom Line: Serum OX40L levels correlated with serum creatinine levels but not with SLEDAI.OX40-OX40L interaction plays a role in the pathogenesis of SLE.Measurements of percentages of CD4+ T-lymphocytes expressing OX40 may serve as an indicator of disease activity in SLE.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams University, Cairo, Egypt.

ABSTRACT

Background and objectives: OX40-OX40L interaction is implicated in the pathogenesis of systemic lupus erythematosus (SLE). We evaluated the role of OX40/OX40L as markers of disease activity and nephritis in SLE patients.

Design and setting: Case-control study conducted in 2009 on SLE patients attending the outpatient clinics of Ain Shams University Hospital, Egypt.

Patients and methods: We assessed the percentage of CD4+ T-lymphocytes expressing OX40 by flowcytometry, and serum OX40 ligand (OX40L) levels in 40 patients with SLE (20 with lupus nephritis and 20 without) and in 20 healthy controls. Disease activity was assessed by the University of Toronto SLE disease activity index (SLEDAI).

Results: The percentage of CD4+ T-lymphocytes expressing OX40 was significantly higher in SLE patients than in controls, and in patients with lupus nephritis than in those without. OX40 expression correlated positively with both serum creatinine levels and SLEDAI. OX40 expression was the highest in patients with class V lupus nephritis and lowest in class II. Serum OX40L levels were significantly higher in SLE patients than in controls, and in patients with nephritis than in those without. Serum OX40L levels correlated with serum creatinine levels but not with SLEDAI. OX40 expression on CD4+ T-cells had a higher sensitivity and specificity in diagnosing lupus nephritis than both OX40L and anti-double-stranded DNA levels.

Conclusion: OX40-OX40L interaction plays a role in the pathogenesis of SLE. The expression of OX40 on CD4+ T-lymphocytes and the serum level of OX40L may act as markers of lupus nephritis. Measurements of percentages of CD4+ T-lymphocytes expressing OX40 may serve as an indicator of disease activity in SLE.

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Correlation between serum levels of OX40L and creatinine.
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Figure 0003: Correlation between serum levels of OX40L and creatinine.

Mentions: Among SLE patients with nephritis, OX40 expression on T-lymphocytes was the highest among class V and lowest among class II. However, a less obvious trend was observed for serum levels of OX40L (Table 4). Among SLE patients, a significant positive correlation was observed between the percentage of OX40 expression on CD4+ T-cells and serum creatinine levels (r=0.78, P<.01) (Figure 1), and between OX40 expression and disease activity measured by SLEDAI (r=0.66, P<.01) (Figure 2). On the other hand, the serum levels of OX40L correlated significantly with serum creatinine levels (r= 0.38, P<.05) (Figure 3) but not with the disease activity as measured by the SLEDAI (r= 0.31, P>.05). Percentages of OX40 expression on CD4+ T-cells showed no significant correlation with anti-dsDNA, C3, or C4 levels (r=0.28, r=–0.19 and r=–0.24, respectively, P>.05). On the other hand, serum levels of OX40L correlated significantly with anti-dsDNA levels (r=0.36, P<.05), but not with C3 or C4 levels (r=–0.23 and r=–0.12, respectively, P>.05).


OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis.

Farres MN, Al-Zifzaf DS, Aly AA, Abd Raboh NM - Ann Saudi Med (2011 Jan-Feb)

Correlation between serum levels of OX40L and creatinine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3101721&req=5

Figure 0003: Correlation between serum levels of OX40L and creatinine.
Mentions: Among SLE patients with nephritis, OX40 expression on T-lymphocytes was the highest among class V and lowest among class II. However, a less obvious trend was observed for serum levels of OX40L (Table 4). Among SLE patients, a significant positive correlation was observed between the percentage of OX40 expression on CD4+ T-cells and serum creatinine levels (r=0.78, P<.01) (Figure 1), and between OX40 expression and disease activity measured by SLEDAI (r=0.66, P<.01) (Figure 2). On the other hand, the serum levels of OX40L correlated significantly with serum creatinine levels (r= 0.38, P<.05) (Figure 3) but not with the disease activity as measured by the SLEDAI (r= 0.31, P>.05). Percentages of OX40 expression on CD4+ T-cells showed no significant correlation with anti-dsDNA, C3, or C4 levels (r=0.28, r=–0.19 and r=–0.24, respectively, P>.05). On the other hand, serum levels of OX40L correlated significantly with anti-dsDNA levels (r=0.36, P<.05), but not with C3 or C4 levels (r=–0.23 and r=–0.12, respectively, P>.05).

Bottom Line: Serum OX40L levels correlated with serum creatinine levels but not with SLEDAI.OX40-OX40L interaction plays a role in the pathogenesis of SLE.Measurements of percentages of CD4+ T-lymphocytes expressing OX40 may serve as an indicator of disease activity in SLE.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams University, Cairo, Egypt.

ABSTRACT

Background and objectives: OX40-OX40L interaction is implicated in the pathogenesis of systemic lupus erythematosus (SLE). We evaluated the role of OX40/OX40L as markers of disease activity and nephritis in SLE patients.

Design and setting: Case-control study conducted in 2009 on SLE patients attending the outpatient clinics of Ain Shams University Hospital, Egypt.

Patients and methods: We assessed the percentage of CD4+ T-lymphocytes expressing OX40 by flowcytometry, and serum OX40 ligand (OX40L) levels in 40 patients with SLE (20 with lupus nephritis and 20 without) and in 20 healthy controls. Disease activity was assessed by the University of Toronto SLE disease activity index (SLEDAI).

Results: The percentage of CD4+ T-lymphocytes expressing OX40 was significantly higher in SLE patients than in controls, and in patients with lupus nephritis than in those without. OX40 expression correlated positively with both serum creatinine levels and SLEDAI. OX40 expression was the highest in patients with class V lupus nephritis and lowest in class II. Serum OX40L levels were significantly higher in SLE patients than in controls, and in patients with nephritis than in those without. Serum OX40L levels correlated with serum creatinine levels but not with SLEDAI. OX40 expression on CD4+ T-cells had a higher sensitivity and specificity in diagnosing lupus nephritis than both OX40L and anti-double-stranded DNA levels.

Conclusion: OX40-OX40L interaction plays a role in the pathogenesis of SLE. The expression of OX40 on CD4+ T-lymphocytes and the serum level of OX40L may act as markers of lupus nephritis. Measurements of percentages of CD4+ T-lymphocytes expressing OX40 may serve as an indicator of disease activity in SLE.

Show MeSH
Related in: MedlinePlus