Limits...
{beta}-Catenin gets an honorable discharge.

Short B - J. Cell Biol. (2010)

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Wnt signaling component is removed from active duty by exosomes.

No MeSH data available.


Related in: MedlinePlus

FOCAL POINT Arthit Chairoungdua (left), Michael Caplan (right), and colleagues reveal a new mechanism by which cells downregulate β-catenin protein levels and activity of the Wnt signaling pathway. The tetraspanin proteins CD82 and CD9 promote the incorporation of β-catenin into exosomes—small vesicles that cells release into their environment. Electron microscopy of purified cell culture supernatants reveals that cells overexpressing CD9 (middle) or CD82 (right) produce more exosomes than control cells (left). Exosomal release of β-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3101596&req=5

fig1: FOCAL POINT Arthit Chairoungdua (left), Michael Caplan (right), and colleagues reveal a new mechanism by which cells downregulate β-catenin protein levels and activity of the Wnt signaling pathway. The tetraspanin proteins CD82 and CD9 promote the incorporation of β-catenin into exosomes—small vesicles that cells release into their environment. Electron microscopy of purified cell culture supernatants reveals that cells overexpressing CD9 (middle) or CD82 (right) produce more exosomes than control cells (left). Exosomal release of β-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis.


{beta}-Catenin gets an honorable discharge.

Short B - J. Cell Biol. (2010)

FOCAL POINT Arthit Chairoungdua (left), Michael Caplan (right), and colleagues reveal a new mechanism by which cells downregulate β-catenin protein levels and activity of the Wnt signaling pathway. The tetraspanin proteins CD82 and CD9 promote the incorporation of β-catenin into exosomes—small vesicles that cells release into their environment. Electron microscopy of purified cell culture supernatants reveals that cells overexpressing CD9 (middle) or CD82 (right) produce more exosomes than control cells (left). Exosomal release of β-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3101596&req=5

fig1: FOCAL POINT Arthit Chairoungdua (left), Michael Caplan (right), and colleagues reveal a new mechanism by which cells downregulate β-catenin protein levels and activity of the Wnt signaling pathway. The tetraspanin proteins CD82 and CD9 promote the incorporation of β-catenin into exosomes—small vesicles that cells release into their environment. Electron microscopy of purified cell culture supernatants reveals that cells overexpressing CD9 (middle) or CD82 (right) produce more exosomes than control cells (left). Exosomal release of β-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Wnt signaling component is removed from active duty by exosomes.

No MeSH data available.


Related in: MedlinePlus