Bottom Line: Reactive oxygen species play important roles as second messengers in many intracellular signalling cascades aimed at maintaining the cell in homeostasis with its immediate environment.At higher levels, they can cause indiscriminate damage to biological molecules, leading to loss of function and even cell death.We will then consider their involvement in normal placental development, and in complications ranging from miscarriage to pre-eclampsia and premature rupture of the membranes.
Affiliation: Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: From the preceding descriptions, it can be seen that oxidative stress may induce a range of cellular responses depending upon the severity of the insult and the compartment in which the ROS are generated. Some of the more major signalling pathways involved and potential outcomes are presented in Fig. 2. The close interaction between oxidative stress and ER stress is important when considering potential therapeutic interventions, as there will be little benefit in addressing one of the stresses without addressing the other.
Affiliation: Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. firstname.lastname@example.org