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Oxidative stress.

Burton GJ, Jauniaux E - Best Pract Res Clin Obstet Gynaecol (2010)

Bottom Line: Reactive oxygen species play important roles as second messengers in many intracellular signalling cascades aimed at maintaining the cell in homeostasis with its immediate environment.At higher levels, they can cause indiscriminate damage to biological molecules, leading to loss of function and even cell death.We will then consider their involvement in normal placental development, and in complications ranging from miscarriage to pre-eclampsia and premature rupture of the membranes.

View Article: PubMed Central - PubMed

Affiliation: Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. gjb2@cam.ac.uk

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How reactive oxygen species may be generated within the syncytiotrophoblast, and the principal consequences for the function of the tissue. CHOP, C/EBP homologous protein; NADPH, nicotinamide adenine dinucleotide phosphate; ROS, reactive oxygen species; UPR, unfolded protein response.
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fig2: How reactive oxygen species may be generated within the syncytiotrophoblast, and the principal consequences for the function of the tissue. CHOP, C/EBP homologous protein; NADPH, nicotinamide adenine dinucleotide phosphate; ROS, reactive oxygen species; UPR, unfolded protein response.

Mentions: From the preceding descriptions, it can be seen that oxidative stress may induce a range of cellular responses depending upon the severity of the insult and the compartment in which the ROS are generated. Some of the more major signalling pathways involved and potential outcomes are presented in Fig. 2. The close interaction between oxidative stress and ER stress is important when considering potential therapeutic interventions, as there will be little benefit in addressing one of the stresses without addressing the other.


Oxidative stress.

Burton GJ, Jauniaux E - Best Pract Res Clin Obstet Gynaecol (2010)

How reactive oxygen species may be generated within the syncytiotrophoblast, and the principal consequences for the function of the tissue. CHOP, C/EBP homologous protein; NADPH, nicotinamide adenine dinucleotide phosphate; ROS, reactive oxygen species; UPR, unfolded protein response.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3101336&req=5

fig2: How reactive oxygen species may be generated within the syncytiotrophoblast, and the principal consequences for the function of the tissue. CHOP, C/EBP homologous protein; NADPH, nicotinamide adenine dinucleotide phosphate; ROS, reactive oxygen species; UPR, unfolded protein response.
Mentions: From the preceding descriptions, it can be seen that oxidative stress may induce a range of cellular responses depending upon the severity of the insult and the compartment in which the ROS are generated. Some of the more major signalling pathways involved and potential outcomes are presented in Fig. 2. The close interaction between oxidative stress and ER stress is important when considering potential therapeutic interventions, as there will be little benefit in addressing one of the stresses without addressing the other.

Bottom Line: Reactive oxygen species play important roles as second messengers in many intracellular signalling cascades aimed at maintaining the cell in homeostasis with its immediate environment.At higher levels, they can cause indiscriminate damage to biological molecules, leading to loss of function and even cell death.We will then consider their involvement in normal placental development, and in complications ranging from miscarriage to pre-eclampsia and premature rupture of the membranes.

View Article: PubMed Central - PubMed

Affiliation: Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. gjb2@cam.ac.uk

Show MeSH
Related in: MedlinePlus