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Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor.

Rong H, Wang G, Liu T, Wang H, Wan Q, Weng S - Int J Mol Sci (2010)

Bottom Line: Chronic mild stress (CMS) affects the hippocampal structure and function in the rat.Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects.This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238#, Wuhan 430060, China; E-Mails: ronghansz@126.com (H.R.); rotsss@126.com (H.W.); wqrooo@yahoo.cn (Q.W.); wshjjkk@126.com (S.W.).

ABSTRACT
Chronic mild stress (CMS) affects the hippocampal structure and function in the rat. S100B, a calcium-binding protein secreted by astrocytes, has been shown to be increased in serum of patients with depression and associated with good therapeutic response and clinical outcome. This work aimed to study the impact of CMS and fluoxetine on depressive-like behaviors in rats, as well as the concomitant expression of the astroglial protein S100B and of its receptor RAGE (receptor for advanced glycation end products) in the hippocampus and Cerebrospinal fluid of the same group of animals. S100B and sRAGE (circulating soluble form of RAGE) were measured in CSF by ELISA, and S100B and RAGE were measured in hippocampal slices by Western blot. Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects. This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

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Effects of CMS, CMS + Flu and Flu on the levels of S100B and sRAGE in the CSF of rats. (* p < 0.05 vs. control, # p < 0.05 vs. CMS). Results are expressed as mean ± S.D. (a) Effects of CMS, CMS + Flu and Flu on the Levels of S100B in the CSF of rats; (b) Effects of CMS, CMS + Flu and Flu on the levels of SRAGE in the CSF of rats.
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f2-ijms-11-05310: Effects of CMS, CMS + Flu and Flu on the levels of S100B and sRAGE in the CSF of rats. (* p < 0.05 vs. control, # p < 0.05 vs. CMS). Results are expressed as mean ± S.D. (a) Effects of CMS, CMS + Flu and Flu on the Levels of S100B in the CSF of rats; (b) Effects of CMS, CMS + Flu and Flu on the levels of SRAGE in the CSF of rats.

Mentions: CSF S100B and sRAGE expression in control rats (Con) and rats subjected to chronic mild stress (CMS), chronic mild stress + fluoxetine (CMS + Flu) or fluoxetine (Flu) (Figure 2a and 2b). CMS significantly downregulated S100B and sRAGE levels, an effect prevented by the concomitant administration of Fluoxetine (CMS + Flu). Figure 2a and 2b [S100B one-way ANOVA, F (3,36) = 5.471, p = 0.003, SRAGE one-way ANOVA, F (3,36) = 6.033, p < 0.02, followed by the Bonferroni test, p < 0.05].


Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor.

Rong H, Wang G, Liu T, Wang H, Wan Q, Weng S - Int J Mol Sci (2010)

Effects of CMS, CMS + Flu and Flu on the levels of S100B and sRAGE in the CSF of rats. (* p < 0.05 vs. control, # p < 0.05 vs. CMS). Results are expressed as mean ± S.D. (a) Effects of CMS, CMS + Flu and Flu on the Levels of S100B in the CSF of rats; (b) Effects of CMS, CMS + Flu and Flu on the levels of SRAGE in the CSF of rats.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3100818&req=5

f2-ijms-11-05310: Effects of CMS, CMS + Flu and Flu on the levels of S100B and sRAGE in the CSF of rats. (* p < 0.05 vs. control, # p < 0.05 vs. CMS). Results are expressed as mean ± S.D. (a) Effects of CMS, CMS + Flu and Flu on the Levels of S100B in the CSF of rats; (b) Effects of CMS, CMS + Flu and Flu on the levels of SRAGE in the CSF of rats.
Mentions: CSF S100B and sRAGE expression in control rats (Con) and rats subjected to chronic mild stress (CMS), chronic mild stress + fluoxetine (CMS + Flu) or fluoxetine (Flu) (Figure 2a and 2b). CMS significantly downregulated S100B and sRAGE levels, an effect prevented by the concomitant administration of Fluoxetine (CMS + Flu). Figure 2a and 2b [S100B one-way ANOVA, F (3,36) = 5.471, p = 0.003, SRAGE one-way ANOVA, F (3,36) = 6.033, p < 0.02, followed by the Bonferroni test, p < 0.05].

Bottom Line: Chronic mild stress (CMS) affects the hippocampal structure and function in the rat.Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects.This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238#, Wuhan 430060, China; E-Mails: ronghansz@126.com (H.R.); rotsss@126.com (H.W.); wqrooo@yahoo.cn (Q.W.); wshjjkk@126.com (S.W.).

ABSTRACT
Chronic mild stress (CMS) affects the hippocampal structure and function in the rat. S100B, a calcium-binding protein secreted by astrocytes, has been shown to be increased in serum of patients with depression and associated with good therapeutic response and clinical outcome. This work aimed to study the impact of CMS and fluoxetine on depressive-like behaviors in rats, as well as the concomitant expression of the astroglial protein S100B and of its receptor RAGE (receptor for advanced glycation end products) in the hippocampus and Cerebrospinal fluid of the same group of animals. S100B and sRAGE (circulating soluble form of RAGE) were measured in CSF by ELISA, and S100B and RAGE were measured in hippocampal slices by Western blot. Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects. This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

Show MeSH
Related in: MedlinePlus