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Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor.

Rong H, Wang G, Liu T, Wang H, Wan Q, Weng S - Int J Mol Sci (2010)

Bottom Line: Chronic mild stress (CMS) affects the hippocampal structure and function in the rat.Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects.This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238#, Wuhan 430060, China; E-Mails: ronghansz@126.com (H.R.); rotsss@126.com (H.W.); wqrooo@yahoo.cn (Q.W.); wshjjkk@126.com (S.W.).

ABSTRACT
Chronic mild stress (CMS) affects the hippocampal structure and function in the rat. S100B, a calcium-binding protein secreted by astrocytes, has been shown to be increased in serum of patients with depression and associated with good therapeutic response and clinical outcome. This work aimed to study the impact of CMS and fluoxetine on depressive-like behaviors in rats, as well as the concomitant expression of the astroglial protein S100B and of its receptor RAGE (receptor for advanced glycation end products) in the hippocampus and Cerebrospinal fluid of the same group of animals. S100B and sRAGE (circulating soluble form of RAGE) were measured in CSF by ELISA, and S100B and RAGE were measured in hippocampal slices by Western blot. Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects. This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

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Related in: MedlinePlus

Effects on sucrose consumption, body weight and open field test. * p < 0.001 vs. control, # p < 0.01 vs. CMS (one-way ANOVA followed by Bonferroni test). Results are expressed as mean ± S.D. (a) 24 h 1% sucrose consumption of rats before and after CMS; (b) Body weight of rats before and after CMS; (c) Crossing of rats before and after CMS; (d) Rears of rats before and after CMS; (e) The urine or excrement frequency of rats before and after CMS.
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f1-ijms-11-05310: Effects on sucrose consumption, body weight and open field test. * p < 0.001 vs. control, # p < 0.01 vs. CMS (one-way ANOVA followed by Bonferroni test). Results are expressed as mean ± S.D. (a) 24 h 1% sucrose consumption of rats before and after CMS; (b) Body weight of rats before and after CMS; (c) Crossing of rats before and after CMS; (d) Rears of rats before and after CMS; (e) The urine or excrement frequency of rats before and after CMS.

Mentions: Sucrose consumption and body weight Figure 1 (a) and (b), crossing (c), number of rears (d), and the urine or excrement frequency (e), were measured twice during the experimental period. As shown, no differences were found among four groups of rats before CMS. The three weeks of chronic stress induced a marked decrease in the sucrose consumption, body weight, crossings and rears of open field activity, but an increase in the urine or excrement frequency in the stressed rats compared to the non-stressed group. [F (3,36) = 7.605, p < 0.001; F (3,36) = 4.132, p < 0.01; F (3,36) = 80.42, p < 0.001; F (3,39) = 98.502, p < 0.001; F (3,36) = 69.369, p < 0.001].


Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor.

Rong H, Wang G, Liu T, Wang H, Wan Q, Weng S - Int J Mol Sci (2010)

Effects on sucrose consumption, body weight and open field test. * p < 0.001 vs. control, # p < 0.01 vs. CMS (one-way ANOVA followed by Bonferroni test). Results are expressed as mean ± S.D. (a) 24 h 1% sucrose consumption of rats before and after CMS; (b) Body weight of rats before and after CMS; (c) Crossing of rats before and after CMS; (d) Rears of rats before and after CMS; (e) The urine or excrement frequency of rats before and after CMS.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3100818&req=5

f1-ijms-11-05310: Effects on sucrose consumption, body weight and open field test. * p < 0.001 vs. control, # p < 0.01 vs. CMS (one-way ANOVA followed by Bonferroni test). Results are expressed as mean ± S.D. (a) 24 h 1% sucrose consumption of rats before and after CMS; (b) Body weight of rats before and after CMS; (c) Crossing of rats before and after CMS; (d) Rears of rats before and after CMS; (e) The urine or excrement frequency of rats before and after CMS.
Mentions: Sucrose consumption and body weight Figure 1 (a) and (b), crossing (c), number of rears (d), and the urine or excrement frequency (e), were measured twice during the experimental period. As shown, no differences were found among four groups of rats before CMS. The three weeks of chronic stress induced a marked decrease in the sucrose consumption, body weight, crossings and rears of open field activity, but an increase in the urine or excrement frequency in the stressed rats compared to the non-stressed group. [F (3,36) = 7.605, p < 0.001; F (3,36) = 4.132, p < 0.01; F (3,36) = 80.42, p < 0.001; F (3,39) = 98.502, p < 0.001; F (3,36) = 69.369, p < 0.001].

Bottom Line: Chronic mild stress (CMS) affects the hippocampal structure and function in the rat.Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects.This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238#, Wuhan 430060, China; E-Mails: ronghansz@126.com (H.R.); rotsss@126.com (H.W.); wqrooo@yahoo.cn (Q.W.); wshjjkk@126.com (S.W.).

ABSTRACT
Chronic mild stress (CMS) affects the hippocampal structure and function in the rat. S100B, a calcium-binding protein secreted by astrocytes, has been shown to be increased in serum of patients with depression and associated with good therapeutic response and clinical outcome. This work aimed to study the impact of CMS and fluoxetine on depressive-like behaviors in rats, as well as the concomitant expression of the astroglial protein S100B and of its receptor RAGE (receptor for advanced glycation end products) in the hippocampus and Cerebrospinal fluid of the same group of animals. S100B and sRAGE (circulating soluble form of RAGE) were measured in CSF by ELISA, and S100B and RAGE were measured in hippocampal slices by Western blot. Our study has demonstrated that stress and depression decrease S100B and RAGE/SRAGE expression and antidepressant treatment reverses or blocks these effects. This result suggested that S100B/RAGE interactions may be involved in the development and maintenance of depression and may play an important role in the mechanism of antidepressants' therapeutic action.

Show MeSH
Related in: MedlinePlus