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The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II.

Smits A, Baumert BG - Int J Mol Imaging (2011)

Bottom Line: We also discuss the value of PET for the long-term followup of this patient group.Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors.As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, Neurology, University Hospital, Uppsala University, 751 85 Uppsala, Sweden.

ABSTRACT
The clinical management of adults with low-grade gliomas (LGGs) remains a challenge. There is no curative treatment, and management of individual patients is a matter of deciding optimal timing as well as right treatment modality. In addition to conventional imaging techniques, positron emission tomography (PET) with amino acid tracers can facilitate diagnostic and therapeutic procedures. In this paper, the clinical applications of PET with amino acid tracers (11)C-methyl-L-methionine (MET) and (18)F-fluoro-ethyl-L-tyrosine (FET) for patients with LGG are summarized. We also discuss the value of PET for the long-term followup of this patient group. Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors. As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.

No MeSH data available.


Related in: MedlinePlus

Transaxial postgadolinium T1-weighted MRI (a) and fused MET PET-MRI (b) for spatial correlation of the MET uptake in a glioma in the left frontotemporal region.
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fig1: Transaxial postgadolinium T1-weighted MRI (a) and fused MET PET-MRI (b) for spatial correlation of the MET uptake in a glioma in the left frontotemporal region.

Mentions: Nowadays, PET images are integrated with CT or MR images to map metabolic activity with anatomical regions and structures in the brain (Figure 1). Quantification of tracer uptake by region of interest (ROI) analysis is performed by using a threshold-based algorithm in this area for the lesion itself and for normal brain areas, usually the cortex of the healthy hemisphere or the cerebellum. Tumor volumes are calculated and hot-spot ratios in the tumor, representing areas with highest uptake, by comparing tumor-to-normal brain ratios. In some studies, the parameter “activity tumor volume” is used, defined by calculating tumor volume combined with mean tumor activity [54].


The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II.

Smits A, Baumert BG - Int J Mol Imaging (2011)

Transaxial postgadolinium T1-weighted MRI (a) and fused MET PET-MRI (b) for spatial correlation of the MET uptake in a glioma in the left frontotemporal region.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3094834&req=5

fig1: Transaxial postgadolinium T1-weighted MRI (a) and fused MET PET-MRI (b) for spatial correlation of the MET uptake in a glioma in the left frontotemporal region.
Mentions: Nowadays, PET images are integrated with CT or MR images to map metabolic activity with anatomical regions and structures in the brain (Figure 1). Quantification of tracer uptake by region of interest (ROI) analysis is performed by using a threshold-based algorithm in this area for the lesion itself and for normal brain areas, usually the cortex of the healthy hemisphere or the cerebellum. Tumor volumes are calculated and hot-spot ratios in the tumor, representing areas with highest uptake, by comparing tumor-to-normal brain ratios. In some studies, the parameter “activity tumor volume” is used, defined by calculating tumor volume combined with mean tumor activity [54].

Bottom Line: We also discuss the value of PET for the long-term followup of this patient group.Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors.As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, Neurology, University Hospital, Uppsala University, 751 85 Uppsala, Sweden.

ABSTRACT
The clinical management of adults with low-grade gliomas (LGGs) remains a challenge. There is no curative treatment, and management of individual patients is a matter of deciding optimal timing as well as right treatment modality. In addition to conventional imaging techniques, positron emission tomography (PET) with amino acid tracers can facilitate diagnostic and therapeutic procedures. In this paper, the clinical applications of PET with amino acid tracers (11)C-methyl-L-methionine (MET) and (18)F-fluoro-ethyl-L-tyrosine (FET) for patients with LGG are summarized. We also discuss the value of PET for the long-term followup of this patient group. Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors. As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.

No MeSH data available.


Related in: MedlinePlus