Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues.
Bottom Line: In segments A2-A4 we find that abdominal A is important for the terminal differentiation of Va cell fate.In the A1 segment, Ultrabithorax acts to specify an alternate Va neuron fate.In contrast, in thoracic segments, Antennapedia suppresses the Va cell fate.
Affiliation: Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, SE-58185, Sweden.Show MeSH
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Mentions: To relate these functional data to the actual expression of these four Hox proteins, we mapped their expression in the Va neurons. Starting from the anterior Va neurons, we find that Antp is the only Hox gene expressed at developmental stage 15 in the T1–T3 neurons. Antp is co-expressed together with the other Hox proteins posteriorly, with the exception of A8 which does not express Antp (Fig. 5D). Ubx is expressed From A1 to A6, and Abd-A in A2 to A7 (Fig. 5B–C). It is noteworthy that A1 Va neurons, which depend upon Ubx for specifying the alternate Va neuron subtype, do not express Abd-A (Fig. 5B, arrowhead). Abd-B is found in A5–A8, but importantly its expression does not extend into A4, in line with the mutant analysis for Abd-B (Fig. 5A, arrowhead).
Affiliation: Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, SE-58185, Sweden.