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Transmission stages dominate trypanosome within-host dynamics during chronic infections.

MacGregor P, Savill NJ, Hall D, Matthews KR - Cell Host Microbe (2011)

Bottom Line: Although a contributor to these dynamics is the density-dependent differentiation from proliferative "slender forms" to transmissible "stumpy forms," an absence of markers discriminating stumpy forms has prevented accurate parameterization of this component.Here, we exploit the stumpy-specific PAD1 marker, which functionally defines transmission competence, to quantitatively monitor stumpy formation during chronic infections.Mathematical modeling of these data describes the parameters controlling trypanosome within-host dynamics and provides strong support for a quorum-sensing-like mechanism.

View Article: PubMed Central - PubMed

Affiliation: Centre for Immunity, Infection, and Evolution, Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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Transmission stages dominate trypanosome within-host dynamics during chronic infections.

MacGregor P, Savill NJ, Hall D, Matthews KR - Cell Host Microbe (2011)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094754&req=5

Bottom Line: Although a contributor to these dynamics is the density-dependent differentiation from proliferative "slender forms" to transmissible "stumpy forms," an absence of markers discriminating stumpy forms has prevented accurate parameterization of this component.Here, we exploit the stumpy-specific PAD1 marker, which functionally defines transmission competence, to quantitatively monitor stumpy formation during chronic infections.Mathematical modeling of these data describes the parameters controlling trypanosome within-host dynamics and provides strong support for a quorum-sensing-like mechanism.

View Article: PubMed Central - PubMed

Affiliation: Centre for Immunity, Infection, and Evolution, Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

Show MeSH
Related in: MedlinePlus