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Efficacy and safety assessment of T. Angelica herbal tonic, a phytomedicinal product popularly used in Nigeria.

Esimone CO, Akah PA, Nworu CS - Evid Based Complement Alternat Med (2011)

Bottom Line: At concentrations up to 300 μg mL(-1), TAHT did not cause any significant effect on acetylcholine, histamine and nicotine-evoked contractions of guinea pig ileum preparation.TAHT exhibited a modest fertility-promoting effect and showed lack of abortifacient and teratogenic properties in the study.Generally, the results of this study showed some favorable pharmacological effects of TAHT in animals which may authenticate some of the label claims.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.

ABSTRACT
T. Angelica Herbal Tonic (TAHT) is a herbal product indicated for indigestion and constipation and highly patronized in Nigeria. In this study, the efficacy and safety of the herbal tonic in relation to the label claims were assessed. The effect on peristalsis in mice was evaluated by the charcoal meal model and in vitro using guinea pig ileum. The effects of TAHT on behavior, fertility, birth and organ weights were also determined. Teratogenic potential and reproductive toxicity were studied in pregnant rats. Acute toxicity studies showed that at doses above 5000 mg kg(-1), the herbal tonic did not cause lethality and produced no signs of intoxication in mice. The study did not show any gross behavioral changes in mice treated with 1000 mg kg(-1) of TAHT as compared with the negative control treatment. TAHT (400 mg kg(-1)) exhibited a dose-dependent enhancement in the gastrointestinal tract motility in mice when compared with the negative control. At concentrations up to 300 μg mL(-1), TAHT did not cause any significant effect on acetylcholine, histamine and nicotine-evoked contractions of guinea pig ileum preparation. It took an average of 31.25 ± 4.52 days for the TAHT-treated animals to litter, which is significantly (P < .05) different from the 55 ± 4.51 days recorded for the control treatment group. TAHT exhibited a modest fertility-promoting effect and showed lack of abortifacient and teratogenic properties in the study. Generally, the results of this study showed some favorable pharmacological effects of TAHT in animals which may authenticate some of the label claims.

No MeSH data available.


Related in: MedlinePlus

Percentage increase in the weight of the litters over a 21-day monitoring period.
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fig2: Percentage increase in the weight of the litters over a 21-day monitoring period.

Mentions: There was no significant difference (P > .05) in the increase in the weight of the virgin rats treated with TAHT and the control treatment after a 15-day monitoring period (Figure 1). It also took an average of 31.25 ± 4.52 days for the test (treated) animals to litter. This is significantly (P < .05) different from the 55 ± 4.51 days that elapsed before delivery was recorded for the control treatment group. By the 43rd day of mating, 80% of the rats in the test group had delivered while none delivered in the control group (Table 3). The mean weight of the litters in the control group (5.95 ± 0.09 g) was found to be significantly higher (P < .05) than that of the test group (4.81 ± 0.19 g) (Figure 2). The mean number of litters was 7.50 ± 0.05 and 5.25 ± 0.95 in the test and control groups, respectively (Table 3). Subsequent monitoring of the litters in both groups showed that there was no significant difference in the percentage increase in weight over the 21-day observation period (Table 3 and Figure 2), indicating lack of developmental effect on lactating animals (Table 3).


Efficacy and safety assessment of T. Angelica herbal tonic, a phytomedicinal product popularly used in Nigeria.

Esimone CO, Akah PA, Nworu CS - Evid Based Complement Alternat Med (2011)

Percentage increase in the weight of the litters over a 21-day monitoring period.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3094697&req=5

fig2: Percentage increase in the weight of the litters over a 21-day monitoring period.
Mentions: There was no significant difference (P > .05) in the increase in the weight of the virgin rats treated with TAHT and the control treatment after a 15-day monitoring period (Figure 1). It also took an average of 31.25 ± 4.52 days for the test (treated) animals to litter. This is significantly (P < .05) different from the 55 ± 4.51 days that elapsed before delivery was recorded for the control treatment group. By the 43rd day of mating, 80% of the rats in the test group had delivered while none delivered in the control group (Table 3). The mean weight of the litters in the control group (5.95 ± 0.09 g) was found to be significantly higher (P < .05) than that of the test group (4.81 ± 0.19 g) (Figure 2). The mean number of litters was 7.50 ± 0.05 and 5.25 ± 0.95 in the test and control groups, respectively (Table 3). Subsequent monitoring of the litters in both groups showed that there was no significant difference in the percentage increase in weight over the 21-day observation period (Table 3 and Figure 2), indicating lack of developmental effect on lactating animals (Table 3).

Bottom Line: At concentrations up to 300 μg mL(-1), TAHT did not cause any significant effect on acetylcholine, histamine and nicotine-evoked contractions of guinea pig ileum preparation.TAHT exhibited a modest fertility-promoting effect and showed lack of abortifacient and teratogenic properties in the study.Generally, the results of this study showed some favorable pharmacological effects of TAHT in animals which may authenticate some of the label claims.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.

ABSTRACT
T. Angelica Herbal Tonic (TAHT) is a herbal product indicated for indigestion and constipation and highly patronized in Nigeria. In this study, the efficacy and safety of the herbal tonic in relation to the label claims were assessed. The effect on peristalsis in mice was evaluated by the charcoal meal model and in vitro using guinea pig ileum. The effects of TAHT on behavior, fertility, birth and organ weights were also determined. Teratogenic potential and reproductive toxicity were studied in pregnant rats. Acute toxicity studies showed that at doses above 5000 mg kg(-1), the herbal tonic did not cause lethality and produced no signs of intoxication in mice. The study did not show any gross behavioral changes in mice treated with 1000 mg kg(-1) of TAHT as compared with the negative control treatment. TAHT (400 mg kg(-1)) exhibited a dose-dependent enhancement in the gastrointestinal tract motility in mice when compared with the negative control. At concentrations up to 300 μg mL(-1), TAHT did not cause any significant effect on acetylcholine, histamine and nicotine-evoked contractions of guinea pig ileum preparation. It took an average of 31.25 ± 4.52 days for the TAHT-treated animals to litter, which is significantly (P < .05) different from the 55 ± 4.51 days recorded for the control treatment group. TAHT exhibited a modest fertility-promoting effect and showed lack of abortifacient and teratogenic properties in the study. Generally, the results of this study showed some favorable pharmacological effects of TAHT in animals which may authenticate some of the label claims.

No MeSH data available.


Related in: MedlinePlus